Conserved Protein Domain Family
Ntox23

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pfam15528: Ntox23 
Bacterial toxin 23
A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system.
Statistics
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PSSM-Id: 317871
View PSSM: pfam15528
Aligned: 8 rows
Threshold Bit Score: 182.65
Threshold Setting Gi: 502466246
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441483268 1219 WGFGANISATFRS-------GDFAISAGIGIMNy--gAH----QGSGKSGWEYRKSLMAGF---E-GKNGNLGFMLGTNM 1281
gi 488783823   69 FNFQTRWQYNVTTy------GPPRLLPGIEVQT----NYgl-mFGWGKQTEVQAYAFLLPFgnqM-KRLNALGYVFNVYH 136
gi 503453584   57 LNAGVTTRYFLTNfgnrsnfGELRLSAGGGVM-------------FGKGNNPLNMDWEGTLh-qS-KSEYSIGYAHYWYL 121
gi 503218407   79 VSFQYNFFYTFKDfgy--yeNSFQHIAGIKLAT-----------AFDRRPIIFRAISNSPF---SsRAFYQFHYFYRYYF 142
gi 288328648 1392 LTAGMLASLSYTD-------GDFSASVSGGITN----NY----VGWNAEA--SYGGWGAGF--------GKTYYGEQTVR 1446
gi 493898762 1867 LTVGLNYGAHYLA-------GDFEFGAGVGVGN----NH----EGWNASG--TYKGWGLGY--------GRTSYLESEVM 1921
gi 488753060 1939 LGLGLNTSLNYTN-------GDFSASLGWGIGSgstgDY----SGWGASA--RYKGWGLGY--------TRTNYSSADN- 1996
gi 502466246 1952 LGVGVNGTFGYQT--------NFGLNIGLNFGA----TYylsaIGTGESGWEKRIGYGIGY---K-GKSFQAGIG-STYF 2014
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441483268 1282 WKGLHQQQTGIVRFQS-GDFSLSYENDgapfghTL---------GD-NHDRLRTAAVNLTI-G----EFSAGFNLFTGER 1345
gi 488783823  137 DKIKTSQTTGTIAFQA-NRFWLVTEND------AL---------GDmAVDKFRTGGVWIAY-QvqntMIALNTRFWTGNS 199
gi 503453584  122 DRIGTAQRSGAWNIGI-QRFDILMEND------VF---------GGqAKDRFRTGGLIVSY-RdslyKASIGLAIWTGET 184
gi 503218407  143 NNWNTSQPTGEIGLNF-GHFFLLHEND------LL---------AAeTVDKFRTAALRIGY-QdslqSIASSFLFWTGNK 205
gi 288328648 1447 GNVLGKQIVGAITLLApGDVSFRLYND------MF---------GQsGHDRWRTSAAELTI-Gd----FSVGTYVTTNDG 1506
gi 493898762 1922 GQKFGAQTVGSLTTYF-NHNSFTFAND------AL---------GD-GKDRWRSSAVELNI-G----KYSLGTYLYTNDG 1979
gi 488753060 1997 ------QVVGGVSLYF-RDVSFRLEND------FF---------GD-GHDRFRSNAFELTV-G----NFTLGSNLYNNDV 2048
gi 502466246 2015 FSGETSQQTGSIYMGG-GNWRLTYEND------TWapvpglftpGTyEKDKYRTAALRFDItGgklkGLNAGLNIFTGKA 2087
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441483268 1346 FESSYYDNKTSYNSsdilsdviphdywqmskssI-GE-----------YGEKYKFGIVKEVG----KQY-RLGAAYVGWG 1408
gi 488783823  200 GRTPVIENANYPAQ-------------------Y-GY-----------RDMSNAMYGRFSHGiltmQVL-QALPYRQIIG 247
gi 503453584  185 GNTTWDRTPRPGAP-------------------N-GI-----------RDLTNNPFGKLNHG----ILYgEIKHRFVGVQ 229
gi 503218407  206 DDPDTKRVNSSDFSr------------------Y-GY-----------FDLSDTPYGKYSHGil-aIDYtRQLPFGNQLR 254
gi 288328648 1507 KEESGIYGYDPNIV-------------------D-PYlganpervihvNGREQKVGGGWPNG----KVY--SAPFWVGIK 1560
gi 493898762 1980 RTESERETIDLAA----------------------PL-----------WRKNKKE--AWTKG----QVY--FAPAWIGYK 2018
gi 488753060 2049 GEKAEIDYNGKMLN-------------------GkPN-----------RPYKGKPMGAWKEG----QTY--SSPLWIGIK 2092
gi 502466246 2088 -----------------------------------EG-----------YDSENIYGGGT--A----DKY-RMGVIYIGYN 2114
                         250       260       270
                  ....*....|....*....|....*....|...
gi 441483268 1409 -----Ny-----RIGIDSDRhVRHAIQNRLAHT 1431
gi 488783823  248 -----A------EVGLDAEI-IRHFLQNKLIHD 268
gi 503453584  230 -----Tvg---gRIGWDSEQ-IRHVFQNKISHD 253
gi 503218407  255 -----I------SSGYDHEK-IRNLIQNKFMHD 275
gi 288328648 1561 -----Sgsq-iyRFGVSARI-VQSLTQN-LVHR 1585
gi 493898762 2019 -----SkngqinRIGFSHPT-VQNLSQN-FIHK 2044
gi 488753060 2093 gagstIy-----RFGYSHPM-VQDRTQN-VTHK 2118
gi 502466246 2115 -----Qy-----RIGYNSERnIRGPIQN-GFHD 2136
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