Conserved Protein Domain Family
PGC7_Stella

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pfam15549: PGC7_Stella 
PGC7/Stella/Dppa3 domain
The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.
Statistics
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PSSM-Id: 317883
View PSSM: pfam15549
Aligned: 16 rows
Threshold Bit Score: 120.312
Threshold Setting Gi: 114145756
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410591611   1 MD--SSEDNPTWTLES-----LKTSIDDASQAMQVATQLs---EMLATNLSNLT--L--NPSIKl-pYLPEYPSQLt--- 62
gi 81866904    1 MEepSEKVDPMKDPET-----PQKKDEEDALDDTDVLQP----ETLVKVMKKLT--L--NPGVKr--SARRRSLRNriaa 65
gi 354476035   1 MDp-LQKWDPMSISMP-----SRMATVTSSQAASAGSHPss-sEKLSMGLSGLR--LirSPGPGvsaPVSEGLLQQ---- 67
gi 432116930   1 MDp-SERITKTFGSDS-----SLNSLEDISQEGASTSQPs--sEAETLDRINFN--N--RPDINypvSRVEELFQQ---- 64
gi 655885746   1 MDp-LQNWSPGFAADA-----SPMAMAETSADSRAASQPps-aEQLVWGLGNMN--P--GAGPDlpvPPPAGLPQQ---- 65
gi 524973682   1 MDp-LQKWDPMSISMP-----SHMATVTSSQEASAGSQPfs-sEKLSMGLSGLSlsR--SPGPGvpaPLSEGLLQQ---- 67
gi 431892842   1 MDp-LQKHSSALISES-----SPMMSKEPSREVAVATHPsf-lQLLMLSLSDLN--P--SPGTSypaH-PKGLRQQ---- 64
gi 984142876   1 -mdplesdaPTSNSDS-----SPIPAEKIPKKVRTTSQPpsfcEIQNLDLIDFT--P--GPVSNyftPLPEELLHF---- 66
gi 982281388   1 MDp-SQQFNPTSIPES-----SQMLTQENSRDDSGASEIc--sEMLIKNLSNLT--I--NASNEspsPLSEDSLHRvidg 68
gi 114145756   1 MDepSEKVDPVVNPETqmydgSQREDEGDSPDDSEILQP----ETLVKVMKKLT--L--NPSAKptkYHRRQRVRLqvks 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410591611  63 --------gQLPSEKTPHRRRGVRTVLSERRYRMQKLIESLRlryakgipRSDSQRQlQQQEdteiRSRvr-rFQCTCSY 133
gi 81866904   66 vpvenksekIRREVQSAFPKRRVRTLLSVLKDPIAKMRRLVR--------IEQRQKRlEGNE----FERdsepFRCLCTF 133
gi 354476035  68 ---------QAREKKALWQQYWEKQGFPQRKKVFLRHSGRWHwdhmtpylLARDVRG-SPSGgn-tQNL----QQC---- 128
gi 432116930  65 ---------QYGDEMTEQEGQGERSAFSNWKKAYTEIMRPNAlpyttpyqIQRKGKI-S-SFgr-yQKK------CQCHY 126
gi 655885746  66 ---------QYREAKT-QQRWYERLPPPQGKKELLGHIRRRHrdhrapypASQEAKL-SPSGdr-pQNR----FHCECRY 129
gi 524973682  68 ---------QAREKKALWQQYWEKQGFPQRKKVFLRHSRRWHrdhmapylLERDVRG-SPSGnr-aQNS----LQC---- 128
gi 431892842  65 ---------RHRDGKTLQERQWEKSVAPQRKKAFLEHMRGRRldhvipyqVQRETRI-TSSGdg-dQNR----FRSDXXX 129
gi 984142876  67 ---------QYRDETTEEERQWERSAFPQRKKTFMGNIRQKAlknmapyqVEREGKI-SLSHgk-dQNG------CKCHY 129
gi 982281388  69 iaarapvlrEIRDDLI-YRRRGVRTLLSVQRE------RMARfrymllgrVRTRERIlTNTGlkgvRKEsr-pFRCPCSF 140
gi 114145756  73 qpvenrserIMREVQSAFPRRRVRTLLSVLKDPIARMRRFVR--------IEQRQRQlEGNE------RrdepFRCLCTF 138
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 410591611 134 CQFKRN--------------PSDdnyeny-ynttysNYAMES 160
gi 81866904  134 CHYQRWd-------------PSE-------------NAKIGK 149
gi 354476035 129 -QGHVPniagmsgdrntppnPPSwetlvq--glnglTLNLGA 167
gi 432116930 127 CQTQKEalpgn----tegqdPPSwktlve--gftnlNFKTDT 162
gi 655885746 130 CQSNGPntsgl----sgergGASwetlvqglsglslslgtsq 167
gi 524973682 129 -QGHVPniaglsgerntasnPPSwetlvq--glsglTLNLGA 167
gi 431892842 130 XQSHTEclwdac---geergPTSfllgnlvqglsgsTLSLGT 168
gi 984142876 130 CQIEREdiskn----pkeeiPSPwkvm--------------- 152
gi 982281388 141 CVSNGWd-------------PSE-------------NARIGN 156
gi 114145756 139 CHYQRWd-------------PSE-------------NAKIGQ 154
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