Conserved Protein Domain Family
Imm35

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pfam15567: Imm35 
Immunity protein 35
A predicted immunity protein with an alpha+beta fold and a conserved tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a protease domain such as Tox-PL1 and Ntox40. In some instances, it is also fused to a papain-like toxin, ADP-ribosyl glycohydrolase and a S8-like peptidase. Based on these associations the domain is likely to be a protease inhibitor.
Statistics
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PSSM-Id: 317896
View PSSM: pfam15567
Aligned: 13 rows
Threshold Bit Score: 77.7902
Threshold Setting Gi: 502763458
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176871       6 DAFAKANHYLDDADLP----------VVITLHGRFSQGWYFCFEAREFLETGDEAARLAgNAPFIIDKDSGEIHslg--- 72
gi 504611807     6 EAKKIAKLFLNRIDTGtrn-----dkCIITDNIEYDFGWIFFYQSSIYLETNDPLYMLAgNIPIIVDRVTKNILf----- 75
gi 1027706818  232 DAVRKARRHLADVYGGqv------vlVDPDPADELDRGWLFACTTRAFLDSGDPRDQML-DAALVVPKDGRRAPfglp-- 302
gi 503052017     5 DARTRAQTALRRLENPeqp----ltlLAPDAPAEYEWCWVYPFNTVRATETGDIMDTLA-VGPLVVPK-NGAEPwvap-- 76
gi 556031535     7 EARDRAADKLRELQDPatp-----lrLSDDPPDEYAWCWVFGFNTERWFRTGELTDGAV-SGPVVVDKD-GGAVwiap-- 77
gi 506285368   230 AAVRRAEEHLAQAYGAgev-----vlVDPSPEDELSRGWLFACTTVAYRDSDDLRYQML-DAALVVPKESDRAPfalp-- 301
gi 497637404   240 TAVAKATAWLEATYGGev------vlVAPAAEDELRRGWLFACTTETFVRTGDWRDQLL-DSALVVPKDDGEDPfglp-- 310
gi 497637043   236 SALAKARSWLDQAYSDdv------vlVAPGPADETRRGWLFACTTARFLGSGHWQDQML-DAALVVPKAAGEEPfglp-- 306
gi 557419235     6 AAVRAVEEHLGREYRQrraagadtmpMVVTGVEEHELVWIVSWTSEAFARTGDPRFLVLgNGPYLVDRVDGGLHrvgv-- 83
gi 511269277     7 EAIAKVQAWLRFGTPVdlttgehavrIEHERVREVPDGWLVPYNTIRALDGGDRLASLV-PRPVLLVRENGELRrpdpep 85
gi 489177908     5 EAIAKVGQWLRAVHGPdvsgp-aglrVDTEKVLRIPEGWSVPYNTIAFLDEGRPEKEIF-PPPSVVVREPDgELrqahph 82
gi 502996071     5 EAAARAREWLCAQPGGdr------lrIRPEFTARRPDGWSFTVNAAAYLDGTDIGAGLF-PGPVVLVPDDGgEIgvdrp- 76
gi 502763458     6 aavrlvEEQLTRDYRTwlatdpdamrMAVVRVREHELVWIVSWQSEEFVRTRRPERMLVgNGPYLVDRVDGsLHqvgv-- 83
                           90       100
                   ....*....|....*....|...
gi 1176871      73 --------takP---L-EEYLQD 83
gi 504611807    76 -----------T---G-SEYDIS 83
gi 1027706818  303 --------nsdPwpwL-ERWDAG 316
gi 503052017    77 --------sgpP---L-ERWLNE 87
gi 556031535    78 --------sapP---L-ERWLNV 88
gi 506285368   302 --------nadPwpwL-ERWDAG 315
gi 497637404   311 --------nedPwgyL-RHWDAH 324
gi 497637043   307 --------nsdPwdyL-AKWDAG 320
gi 557419235    84 -------vsalS---G-E-WEAD 94
gi 511269277    86 gglgpsvpvsfA---GqEDWREI 105
gi 489177908    83 pg-glsvpvafPg--Q-ENWREV 101
gi 502996071    77 ------amastPa--E-AEWRPD 90
gi 502763458    84 -------vsakSg-----AWEAD 94
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