Conserved Protein Domain Family
Mif2_N

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pfam15624: Mif2_N 
Kinetochore CENP-C fungal homolog, Mif2, N-terminal
Mif2_N is a family of fungal proteins homologous to mammalian CENP-C. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore.
Statistics
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PSSM-Id: 317936
View PSSM: pfam15624
Aligned: 37 rows
Threshold Bit Score: 106.627
Threshold Setting Gi: 684175810
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121801278   14 YSNVGKLG----------RRTGITVKE-GKRDEHGMEDIDEMWSSPEKSpVRENGFSNG---Nesl-vgsDGMSM-DEG- 76
gi 74595383    14 YSNVGKAGrpsgtqltvnRRTGITLAE-GKRDEHGMEEVDGIFSSPEKSpLGDNGLDTSesiG-------SDMSM-DEG- 83
gi 296810184   15 YSNVGKAG----------RRTGITLKE-GKRDEHGMEEIEGMFSSPEKSpVRTNGFANDglmNs------EEMETgGSS- 76
gi 326483288   15 YSNVGKAG----------RRTGITLKE-GKRDEHGMEELEGMFSSPEKSpVRTNGFANDglvNs------EEMET-GGT- 75
gi 407926765   13 YFNVGVQG----------RKTGITLKDtGIRDEHGLEPIDGIFSSPEKS----PPTRNNsrqQpdktltsSDMDL-QHSm 77
gi 667825947   16 FHDIGVQG----------RKTGITLKDtGIRDEHGFEPIEGMFSSPEKP------SPRRtsrRtdvtltsEEMEV-QQS- 77
gi 242807717   14 YSNVGKQG----------RRTGITLKE-GRRDEHGMEELDGVFSSPERSpVRMNGLNTG---Ndtv-mgsEGMSI-DEE- 76
gi 557723994   14 YSNVGKAG----------RRTGITLKE-GRRDEHGMEEIEGMFSSPEKSpIGLNGFAHD---Nesd-ndsDGMSI-DDG- 76
gi 325094840   14 YSNVGKAG----------RRTGITLRE-GKLDEHGMEEIEGIFSSPEKSpVKINGHGYG---Ndtl--nsEDMET-GDS- 75
gi 1043335692  15 YSNVGKAG----------RRTGITLKE-GKRDEHGMEELEGMFSSPEKSpVRTNGFA-----Ndgl-mnsEEMETgGSS- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121801278   77 -----------------------------NAPGPADFLSDWLdwvpsenSwfTIIPKPTTGSPL---LYARSKANKKTQE 124
gi 74595383    84 -----------------------------NGPGPADFLSGTNgt----rT--PRFPPPVPRSPS---KSGITGSPRRTPG 125
gi 296810184   77 -----------------------------SIPDPSDVLSARRgg----rN--AYLPPPRSRSPM---KTLMSGSPRRTPG 118
gi 326483288   76 -----------------------------ADHGDVDAESSEAe------E--EQA----GKSPVpvlNTASKGKKRKESE 114
gi 407926765   78 lrhviddsivgalldsdeedtettlqptgSMPEPADALSARRssvrpnrA--SILPPPLGRSPI---KTSLGSSPRRQSS 152
gi 667825947   78 -----------------------------SMPEPTEALSARQllk-gssK--TRFPPPVARSPI---KTSLGSSPRRQSS 122
gi 242807717   77 -----------------------------DGPGPTDFLSRSAtr----rS--PFFPPPIARSPR---KSGLSGSPRRTPA 118
gi 557723994   77 -----------------------------SAPGPGDFLAGASg-----rS--SYFPPPVARSPM---KTGLTGSPRRTPA 117
gi 325094840   76 -----------------------------SIPEPTDVLSGRRgq----rN--PLLLLPRSRSPM---KTHMSGSPRRTPG 117
gi 1043335692  77 -----------------------------SIPDPSDVLSARRgg----rN--AYIPPPRSRSPM---KSLMSGSPRRTPG 118
                         170       180       190
                  ....*....|....*....|....*....|.
gi 121801278  125 VAASFSdsDANSQSNPDeNans-hehTRDDF 154
gi 74595383   126 LRSSQSpqRHLPSSSPSdG-------RSVRR 149
gi 296810184  119 LRSSPL--PQSEFSSPTsArva--akRTINi 145
gi 326483288  115 ---KNL--EEKGDDKPKaNhsgkgrgRKpks 140
gi 407926765  153 MG--PPsaMRRSSNTPNrAisqptvaRRLDF 181
gi 667825947  123 MG--PPsqARRSANTPGrAsshpvvsRKLDF 151
gi 242807717  119 LRSSPIvqIDNVSSSPTsArqrrgrvgedet 149
gi 557723994  118 LRSSPIprNDQPSSSPStG-------RQLNn 141
gi 325094840  118 IRSSSVahHGQ-SSSPTsArpa--arRTLDF 145
gi 1043335692 119 LRSSPLpqSE--FSSPTsThva--akRTINl 145
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