Conserved Protein Domain Family
AROS

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pfam15684: AROS 
Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
AROS is a family of chordate proteins active in the nucleolus. It has a stretch of polylysines at the N-terminus and in the middle regions and it localizes to the nucleus and especially the nucleolus in high concentrations. It binds to the 40S ribosomal protein RPS19, which is implicated in erythropoiesis. AROS is an active regulator of Sirtuin (SIRT1), an NAD+-dependent deacetylase protein that plays a role in cell survival and hormonal signalling, and AROS regulates the activity of SIRT1 by enhancing SIRT1-mediated de-acetylation of p53 and thus regulates growth of the cell.
Statistics
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PSSM-Id: 317987
View PSSM: pfam15684
Aligned: 26 rows
Threshold Bit Score: 40.0691
Threshold Setting Gi: 642917191
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899036    28 ASGTPA------------KR------------TRRARAKasqalklRNSAKGKAPKSALAEYQKR--QCRDHLKANLKFM 81
gi 121956632   31 KRKSDDsdimprhhkmvrYV------------GKKGHKE-------AKDVLRRSESLTVMEARKRiqNRKDNTEDNVRKL 91
gi 260808769   29 RKAQNP------------AEligtnrrgvrkqL--RRLQrgr-rrdDLTVKDKITVSAIEQYKRQ--QKEDHTKDNLRYI 91
gi 170031670   39 DAPLAT------------PDlmpqhhkiikyvGKRGKKEa-------rELLRRPESLTVGEARKRlqNRRNHTEENVQKL 99
gi 405977588   62 SKGRRS------------KAvedsskrgirkrRKRTADHvgk-pksSLSKE-----SALETYNRN--KSVDLTEDSLYYL 121
gi 1032745074  29 tkSSGA------------LDlipvnhriisknKKKG----------STVLLKRSSKITVYDAKKQleTKSDPTEENVKRL 86
gi 749775232   32 SLYTGT------------FElipprhrftteeEKAA----------VIRMLGRSNRLTPQEAKKRlaAQKDRTEENVQRL 89
gi 568250891   30 KRKASA------------LElipkhqklielvGKKGQRI-------EKDLIRRRDKVTVSDIRQQlaNKHDPTEDNVRRL 90
gi 66515340    29 IKYKGTldlippkhrilsKN------------DKTD----------LGTIFGRSSKITVYETQKKlaAQKDSTDKNIQKL 86
gi 746866142   32 IRYKGAldliptkhriisKN------------DKTD----------LDTILGRSSKTTVYETQKRlaTLKDPTDENVQRL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899036    82 ---TS-MRS-TVPESVTQQILQQNQGRKACDRLVAK-TknkkkKKKKAe------------------GTVFTEEDFQKFQ 137
gi 121956632   92 lllSS-A---DIGEEAGAKLVKRAQTGRYVVKADEF-L-----DKKESk------------------ESVFDEEDFKKFE 143
gi 260808769   92 ---RS-FKT-KVDRHLEEKILEHQRGRLAKNQPKKK-R-----KTKETt--------------------VFSEDDFLKFE 140
gi 170031670  100 ---LLlSSA-EIGREASAKMIKRAQTGRYVVKADEFlE-----KKKKEp------------------ASAFTEEDFDNFA 152
gi 405977588  122 nliSN-VGG-KPDAKTVNTILEYNKGKLSRNQKKIE-E-----KRKEQ--------------------SIFSDKDFEDFR 173
gi 1032745074  87 ---LLlSGN-RLDSDTSEKLLSRASKKLIHKKKEEK-P-------VEEe------------------RTVFTEEDFKKFE 136
gi 749775232   90 ---LS-LKTnQLNSNMSNKLLQRAVKNRIKKQ-----E-----KPKESe------------------KTAFTEEDFKKFE 137
gi 568250891   91 lllSS-STC-RLDEETRKKILKRAQTGCYVSKVNLS-K-----KARQEqklkrasskskdgaapaagESVFTEEDFESFA 162
gi 66515340    87 lilSN-N---RIDPNTTNKLLERALKKKYIPKV----------KKPKEs-----------------eTTAFTEEDFKKFE 135
gi 746866142   90 llfSS-N---RINAETANNLLQRAVGKKYIQQ-----------EKLKKs-----------------eETAFTEEDFKNFE 137

                  ...
gi 81899036   138 REY 140
gi 121956632  144 QEL 146
gi 260808769  141 AEY 143
gi 170031670  153 KEL 155
gi 405977588  174 KEY 176
gi 1032745074 137 AEY 139
gi 749775232  138 QEH 140
gi 568250891  163 REL 165
gi 66515340   136 KEY 138
gi 746866142  138 QEY 140
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