Conserved Protein Domain Family
DUF4683

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pfam15735: DUF4683 
Domain of unknown function (DUF4683)
This domain family is found in eukaryotes, and is typically between 384 and 400 amino acids in length.
Statistics
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PSSM-Id: 318032
View PSSM: pfam15735
Aligned: 13 rows
Threshold Bit Score: 449.227
Threshold Setting Gi: 344282002
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395546425   278 NL-FSEEDVDNYMFDDDDSTLGSDVCSLKIRYESFQDNVRDKTNVL-QDDAQFNFFPSV-FTSCSKR---ET---K-NGG 347
gi 528510893   710 TL-EDSPALGPEESEMGQGTKEDDVGELKIRYEDYQENKADRTIVA-QQEAHYKFFPSViLSNCLARpikKQ---A-GSK 783
gi 301615023   738 dltpSVDVSRVILHTADSAINDVSPNKRKVRSEELQEHTTDMSSGN-QQVTHYKFFPSVvLSNCLNR----------PQK 806
gi 556961118   771 VL-CCPEVERSTVSAGESSTDEGSFGKLRIRYENFQEYKSEITSFS-QQETHYKFFPSVvLSNCLDR----------SEK 838
gi 410928855   743 spieedEFLDRQNTGMAKDSEEGDIGELKIRYEDYQENKTEMTVVA-QQEAHYKFFPSViLSNCLTR---KK---VvNKK 815
gi 765161033   731 spmkedgfVNPQKEEMGQETEEGDVGELKIRYEDYQENKTEKTIVA-QQEAHYKFFPSViLSNCLSR---RK---A-GNK 802
gi 565307002   284 NL-FSEEDVDNYMFDDDDSTLGSDVCSLKIRYESFQDNVKEKTGGL-QEDTQFNFFPSV-FSGCPKR---ESr-tA-LKR 355
gi 733899342   283 NL-FSEEDVDNYMFDDDDSTLGSDVCSLKIRYESFQDNVREKTTAL-QEDAQFNFFPSV-FGNCTKR---DSr-sT-LKR 354
gi 344282002   284 NL-FSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLmQEDAQFNFFPSV-FTTCPKR---ESksgA-LKQ 357
gi 1020977499  329 ELvSCSGGSRTVVHSLENNTDEGGLNKLKIRYEEFQEHKAEKPSLS-QQAAHYMFFPSVvLSNCLSR----------PQK 397
gi 928150707   667 ELlSCSGENRTMVHSLDSIADESGLNKLKIRYEEFQEHKTEKPSLS-QQAAHYMFFPSVvLSNCLSR----------PQK 735
gi 637254152   730 SL-SCFEDPSTVIHSSENTTGGDSLNNLKIRYEEFHEYKAQKTNMN-QQAPHYMFFPSVvLSNCLSQ----------PQR 797
gi 565322110   665 TM-SCSESNQTLILSSEKSTDRDSLNNFKLRYEEFEEHKTEKTNVN-QQAAHYMFFPSVvLSNCLNQ----------PQK 732
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395546425   348 lk-rSGDSSQFKVPTES--------------IIWGEEDEEE-------EDKkiRDQE-AEVQEnkRVEE----------- 393
gi 528510893   784 igevSCTLDQPEQRKSR--------------LKLTKKKPTL-------DQK--RELP-VKTHS--PTKE----------- 826
gi 301615023   807 lapvTYKVQQCK-KQSRlklvkklkvveyehPSASEKDIEGllgnqgsVEY--REKK-PLQKQtiVTGTdmtlcpsyqda 882
gi 556961118   839 vislPCKLQQV-DRHSR--------------LKLKKKKLNL-------VSQ--NAKEpVLANDkaDG------------- 881
gi 410928855   816 lgdpDGGIGLGHARRSG--------------PKINKKKLGM-------VGP--RNKS-STVESsiCNTH----------- 860
gi 765161033   803 k--pVDNQELSPSRRSK--------------LKTSKKRLGM-------AGH--RNKT-KLSHDs---TS----------- 842
gi 565307002   356 gprgATDPSQFK-SEET--------------IIWGEEEGDG-------PQE--EEEE-EEEEDdeEGGE----------- 399
gi 733899342   355 gpggATDPSQFK-SEEG--------------IIWGEEEEDG-------EEEdgEEEE-K--------------------- 390
gi 344282002   358 ----SSDLSQFKVPDVS--------------IIWGEEDKNL-------DKK--KDKE-EGQEDkdVEKK----------- 398
gi 1020977499  398 lapvTYKLQQG-NKQSR--------------LKLNKKKHSF-------INR--QQPA-S-VNDvaSV------------- 438
gi 928150707   736 lspvTYKLQPS-SKQSR--------------LKINKKK--L-------IGH--QETS-TKTSEtvST------------- 775
gi 637254152   798 lgpvTYKLQQG-RKQSR--------------LKLTKKK-VL-------LSS--QQPT-N-VCDnpFT------------- 837
gi 565322110   733 lgpvTYKLQHG-KKQSK--------------LKRNKKK-MV-------LGN--QQSA-S-VTDalST------------- 772
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395546425   394 -------EEKEFGGLSALSKPCKgTTDVVKYVN---------SKRNPFL--------------------------D---- 427
gi 528510893   827 -------EPPALLSITPGSHNQN-EVSKEVDMEtsgsliessGKGDFAD--------------------------I---- 868
gi 301615023   883 vnvnalvKDSSYAPGNACSKSPP-DVDRVPSCDmavmmgdgaFQSNACE------------------------------- 930
gi 556961118   882 -------SAIAFTQPNACSSNIS-EESRPLSPNlah----dnDTSVASV--------------------------T---- 919
gi 410928855   861 -------ADPGFTSVTPVCPLTA-DPETSVLKPnpve--vtePVNVDPSiegtpvtkerlewnirpidlikskqpD---- 926
gi 765161033   843 -------TGTSNLTSSSLHSVTV-ETEELVDQPtve----aqSIGDEPM--------------------------Vivkk 884
gi 565307002   400 -------SEK-----VALNKSCT-STELVQYIS---------PKRNHFL--------------------------E---- 427
gi 733899342   391 ---------------AALNKSCN-STEVVQYVG---------PKRSHFL--------------------------D---- 415
gi 344282002   399 -------DRKENGEKPALNKPCS-ETEVEHFKN---------SKQGQLI------------------------------- 430
gi 1020977499  439 -------KEGCYTQGNACS-NIP-DKDSALPSDlvqv-pleaFENKMPT--------------------------S---- 478
gi 928150707   776 -------KDNC-IQNNPCN-SNP-EKDNVLASDlikv-trgaFENKTPI--------------------------D---- 814
gi 637254152   838 -------EESCYIQGNASN-NIP-DKDSSLPNDnevqvphgaFENKMSM--------------------------G---- 878
gi 565322110   773 -------KESCYVQDNTSS-NIP-DRDILLPNDtqvh--htvFENKIST--------------------------D---- 811
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395546425   428 -------------------------------TANSaedsgefs---------ddsscteSSYDAlkeikdcsryltrdph 467
gi 528510893   869 -------------------------------PTNI------------------------SCTKV---------------- 877
gi 301615023   931 --------------------------------LNSfasqf--------------eegatDSEPC---------------- 948
gi 556961118   920 -------------------------------PANRlslhiee-----------esplqlDSEKA---------------- 941
gi 410928855   927 -------------------------------TTMSissekgkdfgedlsnplrelrakvTCMKH---------------- 959
gi 765161033   885 eydesrvnkpmepasellvsnstiitassevPKDFkeqilspd---------edlaakvTCTKP---------------- 939
gi 565307002   428 -------------------------------LVNStedsgess---------ddstcteSSFDVlqdlkdcn------ky 461
gi 733899342   416 -------------------------------SVNStedsgefs---------ddstcteSSYDVlrdikdcs------ry 449
gi 344282002   431 ---------------------------------NSleasvnfs---------ddssfieVSYDAmgeikdcsr----yma 464
gi 1020977499  479 -------------------------------TANYtdcqf--------------adgslETEQS---------------- 497
gi 928150707   815 -------------------------------S--Fidchf--------------gdgtlETEQS---------------- 831
gi 637254152   879 -------------------------------TSNCvdchf--------------edgaqESYQA---------------- 897
gi 565322110   812 -------------------------------TRNYtdchf--------------edfaqESEQT---------------- 830
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395546425   468 sgsssaSTTIQQNYGLRAKRKVRYSEDylydvDSIESERMCekkewqpDGQKEEDDDEWCPk----KRRKVPRKEPPVII 543
gi 528510893   878 ------ASLPGSKYTLRTKRKRIYEKG-----DHPRSGSSK-------QASVHHDDPKGSDhvfsqKKRKVTKKEPPVII 939
gi 301615023   949 ------LEICGNKYTLRGKRKVHFESE-----DGEPVQGATnskssllQPEEATDEVENVQkv--rKRRKVSNKLPPVII 1015
gi 556961118   942 ------FSSCGSKYTLRTKRKINYETE-----DSESSLGSQnsrtshlQFRTSTQNPDNSQqh--wKRKKI--REPPVII 1006
gi 410928855   960 ------LALPGSKYTLRAKRKMAYDKE-----DGLHSGATLsknpvchRERLKDKITPKGQeikftKRRK---KEPPVII 1025
gi 765161033   940 ------SALPGSKYSLRAKRKTVCDGE-----DGEHSGPTQskisssvKKRLKETNVAGGLhvkdqKKRK---KEPPIII 1005
gi 565307002   462 lprdhsSSFIQQNYGLRAKRKVRYSEDylydvDSIESEKIVdkkewipDGPKEEDDDDWCPk----KRRKVSRKEPPVII 537
gi 733899342   450 lsrdhsSSFIQQNYGLRAKRKVRYSDDylydvDSIENEKILdkkewlpDGPKEEDDDEWCPk----KRRKVSRKEPPVII 525
gi 344282002   465 rdtnsgSSSSQQNYGLRAKRKVRYSEDylydvDSLEGEKINerkewlpGGSKEEDDDEWCPk----KRRKVTRKEPPVII 540
gi 1020977499  498 ------FGLCGNKYTLRTKRKVNYETE-----DSESSFVAHnskinlpQPIESVESLDGSQks--rKRRKLSKKLPPVII 564
gi 928150707   832 ------FGLYGNKYTLRAKRKVNYETE-----DSESSFVTHnskislpHSMEIGESLDGTLks--rKRRKMSKKLPPVII 898
gi 637254152   898 ------FGLCGNKYTLRAKRKINYETE-----DSESSFGAHhskinlpHSVGNDECLDGSKkc--qKRRKLAKKLPPVII 964
gi 565322110   831 ------FGLCGNKYTLRAKRKINYETE-----DSESSLGIHnskitlpHSVENDENVDGSKkc--rKRRRLSRKLPPVII 897
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395546425   544 KYIIINRFKGEKHMLVKLSKVDANEMTVTLNENLLHKYARLAPLKGFWQEKQQNR---LDSLRSTLYHKQSfhlngleap 620
gi 528510893   940 KYIIINRFKGQKNMLVKISKVSSDETHTVLTPEKLAGYEQLAPLKKFWPKIPESTa--EKYPSLEPKVKKC--------- 1008
gi 301615023  1016 KYIIINRFKGRKNMLVKLEKLDPSEEQVRLTEDNIKLYNRMAPLKDFWPKVPESPa--TKYPILPITPKKN--------- 1084
gi 556961118  1007 KYIIVNRFKGRKNMLVKIGKVDSKEDSVTLNEHRMETYKKLAPLKDFWPKVPDSLa--TKYPVYPLTPKKI--------- 1075
gi 410928855  1026 KYIIINRFKGQKNMLVKISKVNTEEQMVMLTPDRIDQYNKLAPLKDFWPKVPESTa--VRVPTPE-YKAKK--------- 1093
gi 765161033  1006 KYIIINRFKGQKNMLVKISRMKSGEQSVQLTPDKLEQYNKLAPLKDFWPKVPESPa--VEFPVIELKAKKT--------- 1074
gi 565307002   538 KYIIINRFKGEKHMLVKLGKVDPSEMTVTLSEELLSKYARLAPLKSFWQERWQTR---LNFLKSALYHKQSfylngseva 614
gi 733899342   526 KYIIINRFKGEKHMLVKLSKVDANETTVTLNEELLSKYEKLAPLKGFWQERQQSR---LDLLRSSLYHKQNfylngsdas 602
gi 344282002   541 KYIIINRFKGEKNMLVKLGKVDASETTVNLSENQLNKYSKLAPLKGFWQKKKKQRnnnTDSIKISLCQKQSfepgsfevs 620
gi 1020977499  565 KYIIINRFRGRKNMLVKLGKVDSSEERVVLTEEKMNLYKKLAPLKDFWPKVPDSPa--TKYPIYPLTPKKS--------- 633
gi 928150707   899 KYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPa--TKYPIYPLTPKKS--------- 967
gi 637254152   965 KYIIINRFRGRKNMLVKLGKIDSSEEQVILTEEKMNLYKKLAPLKEFWPKVPDSPa--TKYPVYPLTPKKG--------- 1033
gi 565322110   898 KYIIINRFRGRKNMLVKLGKIDSSEEQVFLTEERMNLYKKLAPLKDFWPKVPDSPa--TKYPIYPLTPKKS--------- 966
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395546425   621 fppPPRKRKCKLANRHRIqR-IQAIEQSTNKQGSF--------------SCDQKQAAG--SKEDAGs------------- 670
gi 528510893  1009 ---PKRKAKINPVVKRMT-T-FPKSKCPRVGQTRGerraka---mlpvqTLAPPWPSYndFTDDTCteycdvmmklgyls 1080
gi 301615023  1085 ---NRRKTKQKSVKKKPG-R-LPKTETKVLKRAIPvrrk------rirsFLSLPIPTYnaETDDCGtdykdvmsklgflv 1153
gi 556961118  1076 ---QKKKTKAKPSLKKKCkN-LRNVDGKNTERTVPskrki-----ssfsTLSPPLPCYtaEAEDCSpeytdvmyklgflt 1146
gi 410928855  1094 ---HKRKTKVNTTNKKT----ICTSSKPQARQGQRvkrtkkcqkdvvlpSLQPPQPCYckHADDHGkeytdvmielgyls 1166
gi 765161033  1075 ---PKRKVKVNSTNKKTPqKgLNNTSKHWLKRGRGvkrakgcqrgpvlpSLPPPRPCYceLTDDRDndykdvmvelgyls 1151
gi 565307002   615 flsHPRKRKGKIAHRHRIqR-IKAIEQPVGKGSSC--------------SSESKQLCCriTDEEGGl------------- 666
gi 733899342   603 flpHPRKRKCKLANRHRIqR-IKAIEQSVNKLGSC--------------SSDHKQPCS--SKEDAGl------------- 652
gi 344282002   621 flsPARKRKSKHGNRHRIqR-IPSMEASTSSKQVSf-------------CNDQKQTN---RKEDGCl------------- 670
gi 1020977499  634 ---HKRKAKHKSTKKKAG-K-PQKTGSTNIKRTLSfrkr-------thtILSPPSPSYsaEAEDCDynysdvmsklgfls 701
gi 928150707   968 ---HRRKSKHKSAKKKTG-K-QQRTNSENIKRTLSfrrk------rshaILSPPSPSYnaETEDCDlnysdvmsklgfls 1036
gi 637254152  1034 ---QKRKAKCKSTKKKIG-K-LHNINSKNIKRSLYfrrr-------phaFLSPPLPSYntEAEDCDlnysdvmsklgfls 1101
gi 565322110   967 ---NKRKAKCKSAKKRLGaK-PQNIKSKTIRRTLYfrkr-------thaFLSPPLPSYsaETEDCDlnysdvmsklgfls 1035
                          570
                   ....*....|....*....
gi 395546425   671 KGAPHTGARATSSCASEAH 689
gi 528510893  1081 ERAPSPTDSTPPRCWSPTE 1099
gi 301615023  1154 ERCPSPINMSPPRCWSPTD 1172
gi 556961118  1147 ERSPSPDKPSPPRCWSPSD 1165
gi 410928855  1167 DRSPSPADSTPPRCWSPSE 1185
gi 765161033  1152 DTSLSPAESTPPRCWSPSD 1170
gi 565307002   667 KGI-QAMAIAAPSCVNGIH 684
gi 733899342   653 KGL-QALAIATPSCANGLH 670
gi 344282002   671 KGTLKPTALTTPSCTNGLH 689
gi 1020977499  702 ERSTSPVNTSPPRCWSPTD 720
gi 928150707  1037 ERSTSPINSSPPRCWSPTD 1055
gi 637254152  1102 ERSASPVSVSPPRCWSPTD 1120
gi 565322110  1036 ERSASPVNVSPPRCWSPTD 1054
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