Conserved Protein Domain Family
CCSAP

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pfam15748: CCSAP 
Centriole, cilia and spindle-associated
This family of microtubule-binding proteins may play a role in embryonic brain development and cilia beating.
Statistics
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PSSM-Id: 318045
View PSSM: pfam15748
Aligned: 25 rows
Threshold Bit Score: 203.394
Threshold Setting Gi: 196011780
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399797   7 RSEYMKKFKDPKWDTYAKCYEDLLKYRLSRRLLEQAHKP----W----FWgeWGSET-------ASSGKSTPLS------ 65
gi 768934962   7 RSEYMKKFKDPKWETYNKCYEDTLKYRLTRRLLEQTHNP----W----FW--RGSDTd-----sDSGGRSPLSLskvrpe 71
gi 47217172    7 RSEYMKKFKDPKWETYTKCYEETLKYRLSRRLLEQTHKP----W----FWs--GSDTd-----sDSGGRSPLPPp----- 66
gi 573901592   7 RTEYMKKFKDPKWETYSKCYEDMLQYRLTRRLLEHTHNP----W----FWegWDSGSd-----sSGSSTPPNSKtg---- 69
gi 432852545   7 RSEYMKKFKDPKWETYAKCYEEMLKYRLTRRLLEHTHKP----W----FWsgSDSDSd-----sG--DRSPPPc------ 65
gi 196011780   3 NSEYRTSFSKLNQKIVHNSYFDNLVYRRSRRNYESNHDHlvfcWddedYWseCKSTStascdgnDSASTSSRHQvaavkd 82
gi 961909657   7 RTEYMKKFRDPKWETFSKCYEDSLKYRLTRRVMEHSHKP----W----IWe--GWETa-----sNSSGWSTPRLs----- 66
gi 528469266  11 KTEYMKKYREPKWETFSKSYEDSLKYRLTRRLMEQTHRP----F----FAe--GWDSg-----sDSSATSSPK------- 68
gi 941792706  22 RSEYMKKFKDPKWETYTKCYEEMLAYRLTRRLLEHTHNP----W----FWs--GSDSd-----sDSGGRSPPHPs----- 81
gi 348534082   7 RSEYMKKFKDPKWDTYTKCYEEMLKYRLTRRLLEHTHNP----W----FWs--GSDTd-----sDSGGRSPPIPp----- 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399797  66 ------RNK------------VEPLKTLD--------------------------E------------------KPER-- 81
gi 768934962  72 ahteacGDR------------LGPDPMVP--------------------------R------------------LPLQde 95
gi 47217172   67 -----sHQAgaeprgalggqgLGPDGPVP--------------------------G------------------LPLQ-- 95
gi 573901592  70 -----eAQK------------PSEEAPKV--------------------------S------------------EKEQ-- 86
gi 432852545  66 ------KNQ------------VGVESSKHteleecv-------------elrktrP------------------EERQ-- 94
gi 196011780  83 -eniikDNK------------VQHNESSK--------------------------S------------------VKCQ-- 103
gi 961909657  67 ------RNK------------VAPLSLPP--------------------------PpplppacsevkqklmevkTSLD-- 100
gi 528469266  69 ------HQE------------VNVPNAKHyi------------------------------------------------- 81
gi 941792706  82 ------KNQ------------VEAGgaeteepegvk--------tdrqretrttgA------------------GPRP-- 115
gi 348534082  67 -----sKNQ------------VRDQEDTGgraeaeleecggartdtqqeqsrtsgP------------------VPRL-- 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399797  82 -------------SACvtPEPAAEAE---------TQAAeVQD--------------------------REHAD------ 107
gi 768934962  96 leevqmsaphlviNGE--TGARGTQA---------QEER-VCN--------------------------GGKQL------ 131
gi 47217172   96 -------------EEA--GEIRVSAPrvgmegkdgAGGTeGQE--------------------------EAGAK------ 128
gi 573901592  87 -------------PEP--PVQPVQPK---------SASAdPAEpr-----------------------vSAGAQ------ 113
gi 432852545  95 -------------TRS--TGPQPRIP---------NPDKqEEDvsapqstvhvsgaqhdgmretrllhvEEKEQ------ 144
gi 196011780 104 --------------GL--KNEKNTNK---------TNHAqVKK--------------------------KKKEN------ 126
gi 961909657 101 -------------LKP--EVKQTEEE---------TGETpVVD--------------------------VAPTAdvleng 130
gi 528469266  82 --------------------sSSESK---------NETAeVLN--------------------------SWKPQ------ 100
gi 941792706 116 -------------TVQneEQIRPDPQ---------SSAHsSQC--------------------------DDTRE------ 141
gi 348534082 110 -------------PIQe-----------------------EEE--------------------------DTGPA------ 121
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399797 108 -----------------TNLVp------------------------cDaevaHPEGEEVRGKERSPA------------- 133
gi 768934962 132 -----------------TMTK--------------------------N----QKEKEAGQTKQTQPS------------- 151
gi 47217172  129 -----------------QAGMp------------------------qS----PKEPEKKAGQSKQRK------------- 150
gi 573901592 114 -----------------RSGAp------------------------tE----RRGSPASPATGQVPEgagqeeegkapgg 148
gi 432852545 145 -----------------RAKGn------------------------kQ----STESPEKVRDFAQPQ------------- 166
gi 196011780 127 -----------------NFNLspnk-------------------sqlS----KELPTKSVATQTVSI------------- 153
gi 961909657 131 lngpgtvsasippdtsgPSDDt------------------------aT----DNRPDSSDSSDEKPV------------- 169
gi 528469266 101 -----------------VNGEvhtdssatlesaarlengykavtsngpsesfpkRRQRHRAPRSEPcypnkdldsde--- 160
gi 941792706 142 -----------------SNRAvqgeeeefs----------------aplrdkekETRAARPHQRKPskstrp-------- 180
gi 348534082 122 -----------------AQSAlhasdamretkv---------lqeeqrasnrerDPEGPRPQQSKPskslrq-------- 167
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399797 134 --V---NPdsdtqiqn---mskskrrsS--------------------------HK--YTRSKVKPQ------APKDPDK 171
gi 768934962 152 --K---FS-------------------K--------------------------RS--WRVSAASTQ------QRREESM 173
gi 47217172  151 --A---SRs-----------------sR--------------------------RC--RRASGATAQ------PRGQDGK 174
gi 573901592 149 epK---SKdpppaap-----aepdhssR--------------------------RPtdPRASGGPAQgrsqtrQPAEPDK 194
gi 432852545 167 --LrksSKt-----------------tK--------------------------RA--QKVRPTPPR------QPRKDAK 193
gi 196011780 154 --K---ESiqkclqkstfakestkscaK--------------------------KE--KKNSAGS--------KVANMKF 192
gi 961909657 170 --N---PAp-----------------rRrhrcrtprsvpvqqdsslekklvvvqKP--PRAKS----------QPAISSK 215
gi 528469266 161 -------------------------------------------------srisisrkpsRAKSQPPGn----sKERTSNR 187
gi 941792706 181 ------------------------------------------------------awrsqRVRPVR--------QLKEDTK 198
gi 348534082 168 ------------------------------------------------------prrsqRVRPAPSR------LPRDDSK 187
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399797 172 ENRHPFALYGAGEKQTDMASKKTHNVGPAASTAEIHESALRAKTRREVEK--QIKRFDKQRARSADLEKSRNKII---PD 246
gi 768934962 174 HRRHPFALYGSGEKDASMAGRKTHNVCPAASTREIHESALRAKTRREVERqiQIQRAECRRAKSADLVKARKVVQ---PE 250
gi 47217172  175 QRRPPFALYASGEKDASTAGRKTHNVCPAASTHEIHESALRAKMRREVERqiQTQRAERWRAKSADLVKGRKATH---PE 251
gi 573901592 195 ENRHPFALYGWAERRAETGLKKTHNVRPSASTKEIHASALRAKTRREVEK--RVRTLERRRARSAELDRLHKAKQp--PV 270
gi 432852545 194 ESRHPFALYGSGERSADMAGRRTHNVGPAASTTEIHESALRARTRREVERqmQIQQNERRRAKSADMEKARRLVE---PE 270
gi 196011780 193 LQKRPLVAYGIGWKDDLCGSRRTFNIQAD---NGVYKSARNAYERRKYSK---------HQANYLSVNKEESISK---ND 257
gi 961909657 216 ANRRPSSRMDWTERQ-----------------PESNMSAAGVQT--QPDR--RSSNLDRRRARSADLEKTRRSQLtmaAA 274
gi 528469266 188 ENRRPFIRYDWAERHIET--RRTPNIRASVSAGEIHRADVGVQTRRESKK--NGRASDHWRARSADVEKSRRSGLs--VA 261
gi 941792706 199 EKRHPFALYGSGEKDADIADRKTHNVGPAASTAEIHESALRAKTRRQVERqiQSRRPERRRAKSADPNKAGMAVQ---PE 275
gi 348534082 188 ESRHPFALYGSGEKDADTAGRKTHNVGPVASTNEIYESALRAKTRREVERqiQTQRSERRRAKSADLDKARKVVQ---PE 264
                        490       500
                 ....*....|....*....|
gi 403399797 247 FNP-------WMTEYMRCFS 259
gi 768934962 251 FNP-------WLTEYMRCFS 263
gi 47217172  252 FNP-------WLTEYMRCFS 264
gi 573901592 271 DNP-------WMTEYMRCFS 283
gi 432852545 271 FNP-------WLSEYMRCFS 283
gi 196011780 258 KNPnlwdasaWKTEYQRCFS 277
gi 961909657 275 DDR-------WMTEYMRCFS 287
gi 528469266 262 DER-------WMTEYMRCFS 274
gi 941792706 276 FNP-------WLTEYMRCFS 288
gi 348534082 265 FNP-------WLTEYMRCFS 277
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