Conserved Protein Domain Family
DUF4735

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pfam15882: DUF4735 
Domain of unknown function (DUF4735)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.
Statistics
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PSSM-Id: 318161
View PSSM: pfam15882
Aligned: 37 rows
Threshold Bit Score: 226.782
Threshold Setting Gi: 196012050
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302595933  52 DGVVGYIILQAQLREAT-----RTW-P-HSDFLSLSQRAAAISMLKRLSKSLSTAASTLQETDPKYFKEFEPILDSSfWS 124
gi 196016802  67 DGYFGFTGSKGFIRATI-----KNY-HdGLSTLNTQQINRVQQIYQRIIAVSKRIEPILANNSMAYNT-IGKIVQGSl-P 138
gi 196016806  53 DSTLSFHFTKGYLRTIL-----EDAsR-NESLLSHNQLDRVTKLYDRFRGLIEDTAPTISQKHYQY--KFLIPLYVRnFK 124
gi 196016800  67 gAYYGLVRCGEYVKATL-----DDYyR-GLSILNVQQLNRIKQIHKRIIDVSKKIQPILAKNSQSY-RQLHKLTQTP-IT 138
gi 353229619  52 DGIFGLIPLKGALESITddslyENY-E-RVKIALLPLMRKLKTQIMRINVIIRKSVKFFKKARDSYYTKMGRLLALK-WN 128
gi 196013984  73 DGYIGLLKAKEYLGATV-----ENI-DkGLSPLSTQQANQVKQIFENCSVLLIHIEAVLVNSSSSKQYDLFKMVHTP-HP 145
gi 752895298  57 DVTYGVTLSEVNLMAAL-----NN--D-NIQYLENKFFVFLKEMLMLSDFTRRNLMNNVVPTSEIELSLQSGLNNVNlWI 128
gi 196012050  82 pSLIGLRIAQGQFEVITn----DRR-F-FNMTLYYDALQMYHQISRLLLADATSEATYWSKKNQKYHSSSNTLVSQP-WK 154
gi 196016838  61 ldAYNLLIAISAFRDITk----EYF-L-ENSYLSSQDVKRISEMNVAVNILFQNS---LEKFSPEYRLVFSEEVSFAa-- 129
gi 393903941  38 DGLFGLRIIEGHLKNIQ-----ENM---NDHDIDSEIMNEIRNLSLMAGMIANKALPFVANRDREYFNQYQFLLHRP-YK 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302595933 125 LPGEWSST------D----PSLVYT----SVRAMEC-----------Y-----D------EHMSDKCMTFL-LGTWKDNG 167
gi 196016802 139 VPKRLVKL------N----FTKLYNvssdEILSPKS-----------G-----Y------MNISDWCIGNI-IGSKALHV 185
gi 196016806 125 VPRKLRKL------N----HTYVQQ----SQE--HS-----------V-----S------RHYSNQCLWEI-VGSWPYYR 165
gi 196016800 139 VPEGLVSL------NftelHHVVLH----DGSPESK-----------N-----W------ENISDSYLHMI-SGSGNY-- 183
gi 353229619 129 FPGQNT-------------MYSYLS----DPEPISS-----------A-----Q------NISSDECIIQL-LNTNNYGT 168
gi 196013984 146 IPNQLISL------R----LSNVHS----GALDKDSta-------gvK-----F------ANISDMCLMDI-IGTRKRHQ 192
gi 752895298 129 KPIWWTRIfpknkpT----PNWGLS----YEQVIES-----------IqhgwpN------EFNSDQCLFKI-MQSGLN-- 180
gi 196012050 155 LSNLDREF------------KLIPV----QIRNERI-----------Y-----DhgihhgNDYGMACLNEL-MGQRNAM- 200
gi 196016838 130 VARYINGT------K----PSLPIS----GPTPANT-----------F-----P------SNMSEICIATT-L-SGSIGS 171
gi 393903941 109 VNFTPQRT------D----ERFRWK----EKQLKTSksdrispppilL-----T------EKQNGRCFNELfLASFNLTA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302595933 168 T--PCIVTKTCR-D-TMTQFGCPHYSLSHQLLYFMIGTMKG-CSKMLKGDL---RLS-RvnitVGHYKRIFCSNMMKSN- 237
gi 196016802 186 A--PCTISDTCW-T-GITNYHGGYYGITHQLITILNGQRLN-CTEKMNKLA---KNL-Gg---IQKVKEVLCTQIYYQM- 252
gi 196016806 166 R--PCNLSDICV-K-FISQLHSNNYIITHQVLALSFGRQFH-CQHQIAPLS---SAF-Gs---VGNLEAILCSRVHKEMy 233
gi 196016800 184 Q--VCTITNTSW-A-DITNYHTDGYIITHQMLNILTGQQFN-CTEKMDKLA---KDL-Gg---IKKVTEVLCTQIYNEMq 251
gi 353229619 169 L--DCHLSMECI-L-KLMDFNSRGYELAHQVLYILISHQVN-CTDSLDGML---SNLsTs---VGSLQNKLCSILYRDF- 236
gi 196013984 193 P--ACTFSDICW-K-GITNYHARNFDIIHQLFAIFVGQKLN-CTNKMNVLA---QKL-Gg---IENVKAALCSRIYRQMy 260
gi 752895298 181 K--KCKIPQTCT-EgLIKHDNVTGYSLTHRLLIIQTAQRFG-CQET----A---SLP-Fs-----YLIPAFCARIFQDL- 242
gi 196012050 201 ---PCTISAECW-Q-SNILEDLQGHKLVRQIIYFMLAKDLK-CHAQVTQRLlhhSKY-Hd---VNDLLQAFCSYAYLEV- 269
gi 196016838 172 A--SCNVTEACW-N-YISQPGTRMGLAVSQLYTDYFIRQLDyCGFKLVKLA---GGI-Rr---LMAVEESLCSRIYMDFk 240
gi 393903941 164 KpySCVLSVDCMkR-MVNQRGFTEYQLTHQILYVAVALQTP-CNFTLSNFI---ALT-Rnq-tITSFITEYCTNMIDEL- 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302595933 238 Q-DIF-K--N-----SLTGQMQDIFIENILLC-G-LVGFSDFYKLDWLQSILTWQDQEAGCF-------------GKEEd 293
gi 196016802 253 QkELK-K--G-----LKNIQMQDLFLEQIFVCgG-WIGYQQFLKAQYLSMMLKWQ-TKAGCF-------------IPYYg 309
gi 196016806 234 S-SLY-K--G-----LTNLKLQDLFTEQVDVC-GsLEFFEDFINETYVDMVLEWQ-TTQGCY-------------MQYNg 289
gi 196016800 252 Q-ELK-K--S-----LTFVPLQDLFLEQMYTC-GaWGGYREFLNMEYLSMFLNWQ-TTAGCI-------------AAYYg 307
gi 353229619 237 V-NLFlS--S-----ETTPRNRDILLEEMFVC-G-SIGYENFIQFSILSRVLSWQQP-SGCFissg------stdGKSKh 299
gi 196013984 261 T-NLN-N--A-----LNKMQSWELFLAQIYICgG-PAGFQKFVDAQFLSAILHWQ-SNTGCL-------------KSSHs 316
gi 752895298 243 V-NLE-A--W-----NFPNVSQDLMIEQIILC-G-MEGYYEFLDKHYEDLILSWP-HWSGCF-------------K---- 293
gi 196012050 270 K-TLY-EqyD-----LKMIQAQQIFLEEIVFC-A-ASGFSDFYNYNFMKEVFQYQ-SFSGCF------------------ 321
gi 196016838 241 K-ILH-N--N-----ISDINKAELLLQQIIICgG-MFGYVEFVSIYPLHQVFKYQ-ARSGCFknsarnrrsqrimHLPCm 309
gi 393903941 236 S-ILL-R--NprimaRLNHDERDMLMEQIFTC-G-QFGFVELSSLHFLASILSWQNPTSGCF---------------TNd 294
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302595933 294 ----------iSHIFEEFLDAPHKRVKRR-----EKTLTD---G-CSSHMTGVAVSALGGFLNFY 339
gi 196016802 310 pfislhpkfnkNYTRDSSQYSSATDELRT-----NLITPD---G-CYEHRTSVALIDVSIYLYWn 365
gi 196016806 290 tyt----sifpNESNGTKLAPYYSRSKRS-----DSTGTD---G-CHQHISSTATVLIVAHLRWL 341
gi 196016800 308 pfvslhpnmtkDYTEDDSRYLFASDQLLI-----DKTITG---D-CDQHTTAIGMSLVAAFLHLg 363
gi 353229619 300 ----------kNTKI-----MFHERHPLV-----EHRHAD---G-CLSHMTSVAAAVMGLYFRAF 340
gi 196013984 317 ----------iFSSLGSELLPQNTLVTSS-----DHPIGGidkA-CYSRRSAAATSVLSMYLHWF 365
gi 752895298 294 ----------------LERISEKLKMTPR-----ASSLTDf--G-CNNHMTSLGAASLALFIRen 334
gi 196012050 322 -------------------SMSKSRRKIRnidhnEKQ--D---AyCPKLKGTIFFLSSVGFIYYH 362
gi 196016838 310 ----------lCLYNSVQISSSLELINSR-----ADLASD---E-CNLHVSTVAFASLATSLRWW 355
gi 393903941 295 ----------kADVMFgdvnks-------yntdglD--PD---L-CSAHSAAVAAGALAVFLRFL 336
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