Conserved Protein Domain Family
FOG_N

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pfam15888: FOG_N 
Folded gastrulation N-terminus
This is the N-terminal domain of the folded gastrulation protein. Folded gastrulation is required for morphogenic movements during gastrulation and nervous system development. It may act as a secreted signal and activate the G protein alpha subunit. This domain may be the G protein-coupled receptor ligand.
Statistics
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PSSM-Id: 318166
View PSSM: pfam15888
Aligned: 9 rows
Threshold Bit Score: 105.689
Threshold Setting Gi: 158293919
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957329  49 KSDRSIFIAPQIVgfnnslCPPNSKLdYDGKCIQ-VVHINPAD---ILVTKLQS---ILg---NGGGSPN---TD-VdTD 114
gi 968099189  77 VMPKSIFALPFRH------CPPGHKL-YNERCIP-QINIDPTD---LVAQELQG---AL----GEGGEVS---SGsP-TD 134
gi 170038104  61 ITPKSIFIAPQLNgfngslCPPDMKVdYNGKCIQvQSNINPAD---IVLTKLQS---LLg---DGGGVSN---AG-GnED 127
gi 968082942  69 VTAKSIFTLPFRR------CPPGHKL-YNERCIP-QTNIDPED---VLKQELIL---AGg---GGVGGPGnggSPvIiTD 131
gi 158293919  70 ITPKSIFITPFLNsyntsaCPPDYKVdYNGKCIQ-VVSINTAD---ILVTKLQSlfsQHg---DGGGSNG---GGtGeDD 139
gi 357613298 109 ITTKSLFITPLV-------CPKGHRLdGAA-CVQ-VVTVNKDEherILLEQLNA---LHiftaAPNNSd---------VF 167
gi 512932301  72 ITTKSLFITPLV-------CPKGQRLdGNG-CVQ-TVTVNKDEherILLEELNA---QFkptlSGDv-----------TY 128
gi 17647433   58 ITAKSIFTLPFRH------CPQGHTL-FNQLCIP-QSNIDPTD---LVKQELIL---A-----GGSNGSP---PPpPiGD 115
gi 964081805  60 VTAKSIFTLPFRH------CPPHHTL-YNELCIP-QSNINPNQ---LIVQELIL---A-----ETANGKP---PPaPiAD 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 121957329 115 YD-Y---YDS--SGPFQVNLPLSiDLPVEQPVpqlAPEETFYDGSVIEVSS-LKQTSTA 166
gi 968099189 135 YD-Ys--DSE--SDEQLYEMSLG-PFAQKDQLstqPSASGAEDQALPSEDApLKFNIFE 187
gi 170038104 128 YD-Ye--YDT--SGPFQVNLPLSiDLPMEEPP---KRAESFYDTMLVDVPSsLTTTTGQ 178
gi 968082942 132 YD-Yg--DEDefSDELLY------DAPQQQPL---MQTTGGEDQALPSEDApLKFNLFE 178
gi 158293919 140 YD-Yd--YDS--TGPFHVNLPLSiDLPPEP-P---QQQAPAQDKAKITTVSlTEPVKPS 189
gi 357613298 168 YD-Yg--DEE--PGPLQLSIPIGlD-PQVSP----------QDPS--AQNQdLTPNFGN 208
gi 512932301 129 YDnYd--ENE--PGPLQLSIPIGlD-PLAAP----LQGQGLSDQA--SQGShDNINKKD 176
gi 17647433  116 YD-Yg-dDEE--SEEIVYDLSVi-PTAMQDGl---PPSVGTGDQALPSEDApLKFNIFE 166
gi 964081805 118 YD-YgdePED--SDEIVFDIG-GiPLPAIGPv-----QPSGQDQALPSEDApLKFNIFE 167
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