Conserved Protein Domain Family
PIEZO

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pfam15917: PIEZO 
Piezo
This domain is found in proteins belonging to the piezo family. Piezo proteins are components of cation channels. This domain is found in association with pfam12166.
Statistics
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PSSM-Id: 318189
View PSSM: pfam15917
Aligned: 38 rows
Threshold Bit Score: 212.914
Threshold Setting Gi: 746864527
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972986198 1297 VACGYINALVENN------CWLIQLFSLACT------IKDYS--------R-----PDSSGKCALP-SDEAGIIWDSICF 1350
gi 158300071  457 FGCLFLEQLVNNN------CWVMQLFGMNCL------SSALP--------PlppgtVDPGEQCNIPpASDAGLFWDGMCF 516
gi 402594873  167 FACAFVHMLIETNl-----CCIRQLFSIVCVsiipgrINNYY--------Lps-eqQEFDKECAVQ-KSETQIGFDTFAF 231
gi 765125660 1305 GSCGYLDSLLKNS------CWLIQAFSMFCT------IKGYDvp-------------ePDDECELP-EGEAGIVWDAICF 1358
gi 47220456   810 GSCAYLGSLMKNS------CWLIQAFSMFCT------IKGYDvp-------------dPDEDCELP-EGEAGIVWDAICF 863
gi 736167498 1300 GSCAYLDSLLKSG------CWFIQAFSLFCT------IKGYDvp-------------aPDDGCELP-EGEAGIVWDAICF 1353
gi 992182361 1295 GSCAYLDSLLKNS------CWLIQAFSMFCT------IKGYDvp-------------ePDDKCELP-VGEAGIVWDAICF 1348
gi 973200965 1294 GSCAYLDSLLKNG------CWFIQTFSMFCT------IKGYNvp-------------pPSDECELP-KSEAGIVWDAICF 1347
gi 746864527 1239 VGCVLIKELEISA------CWLVQLLGIACL-------KKFKsssetlnpAk----------CTVT-SEDIGMVWDGLCF 1294
gi 808356192  506 FGCVFLSWFDQSGgwgktlCIVRQLFSITCVnnechvLKe---------------lEDFSKACAVE-TKEGNIGFDVIAL 569
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972986198 1351 AFLLLQRRVFMSYYFLHVVADIRSSQILASRGAELFQATIIKAVRARIEEEKKSMDQLKRQMDRIKTRQQKFKKGkerml 1430
gi 158300071  517 AFLLLQRRLFSSHYFCHIINESKASKYLASRGAELIEELRIKESAQEAERERQILEKIKAKMDRIKATQQKILEA----- 591
gi 402594873  232 GLLVLQLRIFNSWYFQHCVVEYRSAAVLMNRGTILQDQLIEREMIEQKKQQEKKFKNIKMRTDQIRKDYEK-RLS----- 305
gi 765125660 1359 TVLLVQRRAFLSYYFLYVVSELKSSKILASRGAELFEAKVKKQIAARLEMEKKSVETLKRQMEKIKSKQK---------- 1428
gi 47220456   864 TVLLAQRRVFLSYYFLYVVSDLKSAKILASRGAELFEAKVKKLVAARLELEQKSVETLKKQMEKIKLKQK---------- 933
gi 736167498 1354 TVLLAQRRVFLSYYFLYVVSDLKSSKILASRGAELFEARVKKEVAARLEMEKKSMQTLKKQMEKIKSKQK---------- 1423
gi 992182361 1349 TVLLAQRRIFLSYYFLYVVADLRASKILASRGAELFEAKVKKRVAARLEMEKKSVELLKKDMEKIKSKQR---------- 1418
gi 973200965 1348 IFLLAQRRVFLSYYFLYVVSDLCASKILASRGAELFEAKVKKQVAARLEQEKKSVEMLKKQMEKIKSKQRRFEGG----- 1422
gi 746864527 1295 AFLLIQKRLFKSYYFFHIVDETKAMSILASRGAELLEELHQKRIEIQENVEKTVLEKLKFKMDKIKANQQKIQGP----- 1369
gi 808356192  570 SFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRRRTEAIRERYQK--------- 640
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972986198 1431 slAQQSGEGQNMM-K-EEEEDD------------GE-ADKEKAKGL--------KRQWWR-----------PWVDHAS-- 1474
gi 158300071  592 --DNTTRYDEVTTt--------------------ANgGPTSRRRSR--------SRSYWG-----------PV------- 623
gi 402594873  306 --KAGAFVPQTYGqG-TEAHYP------------NNpN---------------------------------PWYRLGDas 337
gi 765125660 1429 ---GQPTATTKAG-TpAHQAEQmt------------lDKDEKAKKD--------AGKWWK-----------PWVSQPG-- 1471
gi 47220456   934 ---SQPLAVDTPA-PpVSQEQVtlgnklesisffPLfGG---SFLD--------AGKWWK-----------PWVSQPG-- 985
gi 736167498 1424 ---GGP--ADKPV-LpVDQEQVt-------------lADDEKAKKD--------VGKWWK-----------PWVSQPG-- 1463
gi 992182361 1419 ----------------------------------SQpAQEPQHQSDtepkednpQENWMK-----------PWVSRPS-- 1451
gi 973200965 1423 --EGAPAVQGDAD-VdPTQEEDr----------dSQgGSEKGDKRD--------RKKWWR-----------PWVTHSSsk 1470
gi 746864527 1370 ----------------------------------SYkESQAHKVDE--------LYPRTR-----------PLYKIRSpq 1396
gi 808356192  641 ----------------------------------QIeRGAAERDFE--------PVTYGHecmrideddpfPYYDLRIss 678
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972986198 1475 -------------------------------------------MVRSGDYYLF-E-------------TdSEEEEE-ED- 1495
gi 158300071  624 -------------------------------------------AIRSGDYYMF-EdveqefeldlmepHeYDDELDeRS- 658
gi 402594873  338 ers-----------------------------------dyrllAKRAGDYYMF-E-------------YdPSEDVLdEP- 367
gi 765125660 1472 -------------------------------------------VENNCGYHLF-E-------------SdSEEEEEeTT- 1493
gi 47220456   986 -------------------------------------------VENNCGYHLF-E-------------SdHEEEEEeATe 1008
gi 736167498 1464 -------------------------------------------VENNCGYHLFeS-------------DsEEEEGDdVTe 1487
gi 992182361 1452 -------------------------------------------VWDSCGYRLF-E-------------SdSEEEDCvPPe 1474
gi 973200965 1471 ycvvlfaprplpgclllcrlpstsawtgsalgpvcfrvcarstVVRSGSYYLF-E-------------SdSEEEEEePEg 1536
gi 746864527 1397 t---------------------------------------nreAIRSGDYYMF-DdlddddvtdlvpdSdIEKKEKeRR- 1435
gi 808356192  679 qd-------------------------------------teneAKRAGDYYMF-K-------------YdPENDDLvEPv 707
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 972986198 1496 ---KK----EEEPH-----K----KS-A-------FQFVYHAWITDSKTAL 1522
gi 158300071  659 ---QK----DQRLR-----R----RL-T-------LGRV----SVCLEGSE 681
gi 402594873  368 ---VEtfvpEVTPGasdfnK----LD-P-------VQLMHTAVQHDLDLSQ 403
gi 765125660 1494 ------------EK-----K----EEeEppkkksaFQLAYNAWVTSSKSAL 1523
gi 47220456  1009 k-kEE----DEPTK-----K----KS-A-------FHLAYNAWVTSSKKAL 1037
gi 736167498 1488 k-nEE----KPPPK-----K----KS-A-------FQLAYDAWVNSSKSAL 1516
gi 992182361 1475 dkkED----EPVPK-----K----KS-A-------LQLVYEAWVAGSKAAL 1504
gi 973200965 1537 --kEE----EAPAK-----K----KT-A-------FQLAYEAWVTSSKAAL 1564
gi 746864527 1436 ---RE----QERKG-----R----RMtV-------SELMNTLIKTDIEIAT 1463
gi 808356192  708 dsfVP----EVDPK-----AtaydRLdP-------GQIMYAATAHDLDLAK 742
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