Conserved Protein Domain Family
DUF4746

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pfam15928: DUF4746 
Domain of unknown function (DUF4746)
This presumed domain is functionally uncharacterized. This domain is found in eukaryotes, and is typically between 247 and 324 amino acids in length. The family is found in association with pfam00085.
Statistics
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PSSM-Id: 318199
View PSSM: pfam15928
Aligned: 19 rows
Threshold Bit Score: 264.277
Threshold Setting Gi: 357617762
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75027721  234 DVIEQLDGKELLMCFWKIDESIGTV-PN-VLMAYAHELTKEr--VAPPNDDIPEEHVI--------PPL----------- 290
gi 122094473 237 EVFEQIFYKEVQGYVWKRQDDVSRApED-VIGDFVRFLTEP---NEVLDNDGNVEKVI--------PPL----------- 293
gi 969505558 234 DVIEQLDGKELLMCFWKIDETVGSV-PN-VLGAYAHELTKEr--VAPPNEEFDEEHVI--------PPI----------- 290
gi 568255584 261 DVFEQIYYKDIQAYVWKLNEGETRP-PEeVIGAFVKIITEP---VEVLDADGNVEKVI--------PRM----------- 317
gi 357617762 259 aCIHALMNGEALVVLFKMFDTDDR---D-FVKLMRHTLYEE---IPVPKEDLPPEKQL--------PPIpaferyatisk 323
gi 322799717 244 ELIKGLTDGKCMAMRLK----GKPPhPD-WPVHYPYESPERdsvKYPIRAIDDVENYLvsiitkgpPPP----------- 307
gi 746842566 244 ELIKGLTDGKCMAMRLK----GKPPhPD-WPVQYPYESPERd--SYPVRAINDVENYLisiltqgpPTF----------- 305
gi 307185567 244 ELIKGLTDGKCMAMRLK----GKPPhPD-WPVHYPHECPERnsmKCPIRAIDDVENYLisiittqpPPL----------- 307
gi 158300307 237 DVFEQIYYKDIQAYVWKLTEGETRSpEE-VIGAFVKIITEP---VEVLDADGNVEKVI--------PRM----------- 293
gi 195131725 233 DIIEQLDGKELLICFWKIDESSGPI-PH-VLATYAHELTKEr--VAPPDDDHPAPHPI--------PPI----------- 289
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75027721  291 -------------ITTMKLKVEVE--LKegetwveeisseeeARL-----------HQAKSKAKTKsish---eeahLAE 341
gi 122094473 294 -------------IEPLEMLYNAN--DG--------------TWK-----------MIDKNPKKKKs----------GVN 323
gi 969505558 291 -------------ISPMKVKVEVK--LEegeewveeisseedTKK-----------YMAKPKVKSIinft---edavAVD 341
gi 568255584 318 -------------IEPLEMQYie------------------gTWR-----------MVAKLPPQKSgss------iaTTT 349
gi 357617762 324 tarevrreryearMEKLRQEKEDR--DRlaa--------eqaRLAreeeeerqrleKQRQEEERMAriqaglpadpePEP 393
gi 322799717 308 --------------------------------------------------------------LQADvpaik-ptydaPYV 324
gi 746842566 306 --------------------------------------------------------------SQTEgpeir-ptydtPYM 322
gi 307185567 308 ------------------------------------------------------------IGTEAGaplsrltydnvPYI 327
gi 158300307 294 -------------IEPLEMLY--SanDG--------------TWK-----------MVSKLPPQKSass------iaTTN 327
gi 195131725 290 -------------ISPMKVKFEVE--VEegevwveeissseeARQ-----------KAAEKKAAEKakag---aqpdDAH 340
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75027721  342 EEAADLD-------------AEEEASEEEtvmpepggdamgglpsmpgfeleiepvdeagedeeevqeikeeepskpltR 408
gi 122094473 324 LNASQST-------------SSKETFDEE--------------------------------------------------S 340
gi 969505558 342 DEGDDLA-------------GEEEGSEEDlpeldirqsmanlgidldldld-------lddsgeeeeevveeviakpliR 401
gi 568255584 350 SSDSSQN-------------VSKETFDEDa-------------------------------------------------- 366
gi 357617762 394 AQEAGEEggeeavegeetevAETEDIEEPeqkeeeqveveee------------------------fhsdvsvedeeyiP 449
gi 322799717 325 QRHVHVH-------------EPDPEIEGD--------------------------------------------------- 340
gi 746842566 323 ERHVYEY-------------EPE--IEDD--------------------------------------------------- 336
gi 307185567 328 ERHVYVH-------------EPDPKIEGD--------------------------------------------------- 343
gi 158300307 328 SSDSSQN-------------VSKETFDEE--------------------------------------------------A 344
gi 195131725 341 KEEVEDD-------------GEEEGSEEEevvqaiqpafpgmqldldlgld-------divateeeaeeeeeeapkpltR 400
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75027721  409 TKTVKM--PPIWVPNSRRTHAALIYVFFRGQ---------------------------TSGFLP-PDPKPEPPHVIMAFD 458
gi 122094473 341 CPKIYV--PGVWSPTNRRATAALFYLLFRHL---------------------------TESFLG-PDPVPEPPHICIVFD 390
gi 969505558 402 TRTVKM--PPVWVPSNRRTHAALVYMFFRSQ---------------------------TSGFLP-PDPKPEPPHVIMAFD 451
gi 568255584 367 CPRLII--PGVWTPTNRRANAALIYLLFRHL---------------------------TEHFLP-PDPVPEPPHICMVFD 416
gi 357617762 450 PGGLFV--PGLYTPPNDLAKANALAYFYPKI---------------------------VSQITP-IESEFLPPHVLVMFT 499
gi 322799717 341 ---VRRvhPAAWVPPQARSKVHVFKTLFPAY---------------------------LEKAHPyEEPAVPPPLCAFKFD 390
gi 746842566 337 ---VSRvyPAVWVPPQARSKVHAFKTLFSGY---------------------------MEKAHPyEEPTVPPPLCAFKFE 386
gi 307185567 344 ---VRRvhPAAWVPPQARSKVNVFKTLFPTY---------------------------MEKTHPyEEPVPSLPLCAFKFD 393
gi 158300307 345 CPRLII--PGVWTPTNRRANAALFYLLFRHVsnrkgfglfnftvhnvpvifsipstrsTEHFLP-PDPVPEPPHICMVFD 421
gi 195131725 401 TKRVKI--PPIWVANNRRTHAALIYVFFRNQ---------------------------TTGFLP-PDPPPEPPHVIMAFE 450
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75027721  459 ASKRKEIMHVI--DRHKDDVPLYGFFSSAEPDEAELIATSTDKYE-SSP--HSSGDKIVLKVNKVQSNMMLSLVSYGPSY 533
gi 122094473 391 AYKKRDVFEVI--AKFNRDVMAYGYFTSGDPKTAELIAKKTERYV-RLK--PNVNDKLILKVAKATSHAMLALTAVGPCY 465
gi 969505558 452 ASKRRDILSVV--DRHKSEVPAYGFFTSDDPDETRLLATSTDRYD-KSGe-ISPSDKIVLKVTKVQSNMMLSLVSYGPSY 527
gi 568255584 417 AYKKRDVLEVAmnDKYKTQVMAFGYFSTGDPKTAELIAKTTERYV-TKK--PNVNDKLIMKVSKATSHAMLALTAMGPCY 493
gi 357617762 500 IEKRHDVKDIM--DQFPDEILNYGIFIGDDPTTAQHLAYTIKQYN-HMSriRKHNDRLALMVSRKRSLPMLQLAGVNPCY 576
gi 322799717 391 ASKFSIVRDGY--ELNFDAIEHFGAFEFDQPPYARRLASSPEDFE-KVKy-KTGGEVFVVIIRRINEEAFLAFAGNDPLF 466
gi 746842566 387 VSKFNIVRDAY--ELNCDAIEHFGVFEFDRP-YARRLASSPQDFE-KVKy-KTGVEVFVVIIRRINEETFLAFAGIEPFF 461
gi 307185567 394 ASKFGVVRDTY--EKYRDTIEHFGVFEFDQPPHARRLVSSPEDFEnKVKy-KTGDEVFVVIIRRISEEAFLAFASIGPFF 470
gi 158300307 422 AYKKRDVLEVAmnEKYKTQVMAFGYFSTGDPKTAELIAKTTERYT-TKR--PNVNDKLIMKVSKATSHAMLALTAMGPCY 498
gi 195131725 451 ASKRDDILEVM--ESIKDDVPLYGFFTSDTPGEAKLISNSIFRYD-DMKe-TAKTDRFVLKVNKVQSYTMLSLVQFEPTY 526
                        410       420       430
                 ....*....|....*....|....*....|...
gi 75027721  534 VSPNVTVGKDEALKFFPEDYKP------QEEVV 560
gi 122094473 466 ISQNAVEGQEECALLFPPNYDNi-----EEEAE 493
gi 969505558 528 VSPNVTAGREEGLKFFAEGYKQ------ESEVP 554
gi 568255584 494 VSQNAVEGQEECAALFPPNYNFveeenetgeve 526
gi 357617762 577 ISHDVESGEKDCLIMFPVGYGDdyeeeesvhee 609
gi 322799717 467 VTEVDEEAQEMITEYFPEGAKDvptlapAEQEV 499
gi 746842566 462 VTEVDEEVQEVITAYFSKGVEDvt------pEE 488
gi 307185567 471 VTEVDEEAQGMLTEYFPEGVKDvilltpDEQEA 503
gi 158300307 499 VSQNAVEGQEECAALFPPNYNFv-----EEENE 526
gi 195131725 527 CSSNVENGRLDALKFFPEDYKT------DEEIP 553
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