Conserved Protein Domain Family
MITF_TFEB_C_3_N

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pfam15951: MITF_TFEB_C_3_N 
MITF/TFEB/TFEC/TFE3 N-terminus
This domain is found at the N-terminus of several transcription factors including microphthalmia-associated transcription factor, transcription factor EB, transcription factor EC and transcription factor E3.
Statistics
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PSSM-Id: 318217
View PSSM: pfam15951
Aligned: 27 rows
Threshold Bit Score: 103.643
Threshold Setting Gi: 768913194
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528494205    4 RIGLRLQLMRDQMQQEEQRErqQQQAVSMHYMQHRMPgppEPT--Pa-ISA-----------PT--HfQGPMQVPVEVLK 67
gi 242021720   69 RTQFKQILMWSQEFLEQQKE--QDKKKNDDVTKVNKP---ISN--P--VSV-----------PR--N-IQSLKVPSHVLQ 125
gi 762128887  179 RANLRLQLMRLQTEQEEKKN-----EQTPSYSQSYRP---AHTapQs-IQI-----------PAg-SvSSSTEVPTRVLT 237
gi 345324574   36 RVLLRQQLMRAQTQEQERREq-QQQAASAQFLAERAAppvPAT--Pa-ISVn---------sAM--GrPAPAQVPMEVLK 100
gi 884864516    8 RVLLRQQLMRAQAQEQERREr-REQAAATAFPNPA-----PAS--Pa-ISVvgv-----stgGHtlSrPPPAQVPREVLK 73
gi 821494426    4 RILLRQQLMRAQAQEQEQREr-RERAASGAFSGGPAP---PAS--Pa-ISVvvgaspggpsgGVglTrPASAQVPVEVLK 76
gi 637341619   89 RVLLRQQLMRAQTQEQERRE----QQQAAQFTPTPLA---PST--Pa-ISVs----------PL--ArPAPAQVPVEVLK 146
gi 565318836   63 RVLLRQQLMRAQTQEQELRE----QRQAAQFTPAPAA---SAT--Pa-ISVs----------PL--ArPAPAQVPVEVLK 120
gi 768913194  102 RVLMRQDLMRQQALEEQQKEa---QQQLLRSAD-------SSS--PmfVSV-----------SS--ScQPPAQVPVEVLK 156
gi 348540407  101 RVLMRQDLMRQQALEEEHKEaqKQQQQLLRFSD-------SSS--PicVSV-----------PS--ScIPPAQVPVEVLK 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528494205   68 VQTHLENPTDYHIRQSQRQQVKEYLSTTYATKQavhavtslvqpspppMVQAQTGSAPPNMHSPCMR---TEQLMNSAGN 144
gi 242021720  126 VTTKLQHPTKYHIKAKQENQVWQYLNSAQPENV---------------FMRKSGVQSEPITQEPKAKsklEYNSVTCPTL 190
gi 762128887  238 VKTQLENPTQFHVTENQKRQIHLFLHNSGKVTTa-------------qSMPALTTQIPGANMVP-----------TTVSG 293
gi 345324574  101 VQTHLENPTKYHIQQAQRQQVKQYLSTALGPKMasq---------alaPPVPPPAPSPQPEGPA----------LPPPSG 161
gi 884864516   74 VQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLasqa-------ltppPGPTSAQPLPAPEAAH----------ATGPTG 136
gi 821494426   77 VQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLasqa-------ltppPAEGTSAERSQP-----------------AAG 132
gi 637341619  147 VQTHLENPTKYHIQQAQRQQVKQYLSTAMGNKMatqala----gaspgAPSCSPQAASAPESQHSLAqqqQQQGVAGGTG 222
gi 565318836  121 VQTHLENPTKYHIQQAQRQQVKQYLSTA--SKMstqalt----gtspgAPTCSPQAISGPEPPPGLA---HQQGVAGSTG 191
gi 768913194  157 VQTHLENPTRYHIQQAQRQQVRRYLSTAKTAMKa----------------aNQEPAAATPQESPQLSpapKVE----SPN 216
gi 348540407  159 VQTHLENPTRYHIQQAQRQQVRQYLSTTKTANQ------------------QQAAVASHSTLGQPVDgspEQEvediivd 220
                         170
                  ....*....|....*..
gi 528494205  145 SAPNspmaMLNISSSHE 161
gi 242021720  191 PSPE----ILSPSASRA 203
gi 762128887  294 SAPVdpdsPLSMGLSSA 310
gi 345324574  162 SAPNspmaMLNISSNSE 178
gi 884864516  137 SAPNspmaLLTIGSSSE 153
gi 821494426  133 SAPNspmaLLNIGSSSE 149
gi 637341619  223 SAPNspmaMLNIGSSSE 239
gi 565318836  192 SAPNspmaMLNIGSNSE 208
gi 768913194  217 SLQKtevdeaviddiis 233
gi 348540407  221 diisldsslndefltli 237
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