Conserved Protein Domain Family
Comm

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pfam15957: Comm 
Commissureless
Commissureless regulates Roundabout (Robo) levels and as a result regulates controls axon guidance across the embryo midline.
Statistics
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PSSM-Id: 318222
View PSSM: pfam15957
Aligned: 7 rows
Threshold Bit Score: 125.286
Threshold Setting Gi: 170064550
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121955972  97 PTYERFIGDVWVGIVLTLMILSSIFCMCS--CFLyh--------------kfRQWQ------------------------ 136
6_pfamImport   1 YSYRSTSTIVLMVSAWILLILGFVFCCCAecCGV------------------SVWRgkktrssididglnqa--eqggng 60
4_pfamImport   1 EDFAHVVSDIWIGVILTLLIVFVIFFICA--CFLyh--------------kfQQWK------------------------ 40
5_pfamImport   1 -EYDKFMNEVWIGIVFTLILISMVFCICS--CFLyh--------------qfRTWK------------------------ 39
3_pfamImport   1 ADMHVIINYLWIGVVTSLVVLSLVFILFS--CYFyr--------------kfRTWKkcnkdiraqihaasdssysthlvn 64
gi 170062112 105 gpllvdpSYLWIGAVMVLLVLSGLFCVCS--CYLyy--------------kyRRWQ------------------------ 144
gi 170064550 104 PTYERFIGDVWVGIVLTLMILSSIFCMCS--CFLttsfasgnevvstaagitRSWN------------------------ 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121955972 137 ---------RSV--------LTARsq------tlSSMDLETPPPYDV------E------SLPSYTIVSGLPSYNDAIEQ 181
6_pfamImport  61 ngsasardaTAD--------RANHsd------ptIEICRRCPPDYEA------E------SLPSYTIVSGLPTYDDALEE 114
4_pfamImport  41 ---------NSY--------RANHgd------atIEVCRHCPPEYEA------E------SLPSYTIVSGLPTYDDALEE 85
5_pfamImport  40 ---------RNY--------RNNAngst--qctiVDIEALKLHPDVE------D------PVPEYTLVSGLPSYEAALEL 88
3_pfamImport  65 cdasrlllhQQQ--------QIQQ----------QHQRNNEAAFYQI------E------SPPCYTIATGLPSYDEALHH 114
gi 170062112 145 ---------KCV--------SITSchqpp-hgtlVG-DVESPPPYDP------EttttaaTLPSYTVASGLPSYEDAVEH 199
gi 170064550 158 ---------NGYtppptsgtRSTGaghvflsrsaTTMGGQLLLSYSSlfcatcL------DAPEY--VDGLWDYGGRIHR 220
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 121955972 182 LKQKQQqkspgg-hlepvkLQRPSVI---KLFEsqSQ 214
6_pfamImport 115 FRKAGI-------------ILTPAMVpiiKIFE--CN 136
4_pfamImport  86 FRKAGI-------------ILTPSFVpviKIFEsaSN 109
5_pfamImport  89 LQKSPQss---------clIVYPSVF---NVFNkqE- 112
3_pfamImport 115 QPRHFAyg---------mkFVYPTLA---AVHHhhHH 139
gi 170062112 200 IYRQQQlqrqnpppaqptsVHPPATV---KFFEsrPQ 233
gi 170064550 221 s------------------AWFPASV---GITAgeAG 236
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