Conserved Protein Domain Family
JAKMIP_CC3

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pfam16034: JAKMIP_CC3 
JAKMIP CC3 domain
This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.
Statistics
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PSSM-Id: 318290
View PSSM: pfam16034
Aligned: 12 rows
Threshold Bit Score: 121.478
Threshold Setting Gi: 0
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
11_pfamImport   1 ERDKLLRYRKQRKKMAKLPKKPv--VVETFFGYDEEaSLESDGSSI-SYQTDRTDQTPC-TPD----DD--LEE----GV 66
4_pfamImport    1 ERDRLIINKKNRRKNIKLPKRH---VVETYFGFDEE-SVDSETSSLtSYNTDRTDYTPA-TPE----ED--LED----GF 65
9_pfamImport    1 ERDRLVMSRKVRKKPCKLLNRN---VVETYFGFDEE-SVDSETSSLtSYNTDLTDRTPA-TPE----ED--LEE----NV 65
1_pfamImport    1 HEEKVIVRSKPPIPPKP----------------------DVRTIPApSQGQQRVSISPTgTPQ----SKgcKKQ----QV 50
2_pfamImport    1 ERDKIISALREAAEEKDKKLEDlimEYTKMKNNDYGnKLDLESTTD-STNHRGNLSSPS-SPPlcngELcwTDN----FV 74
3_pfamImport    1 DREKLLRKKRHKR-SRPIKRHI---VVDTFYGYDEE-SMDSETSSVaSLRMDR---TPA-TPD----ED--LDE----GL 61
7_pfamImport    1 -REKLIRRRKHRRSSKPIKRP----VLDPFIGYDED-SMDSETSSMaSFRTDR---TPA-TPD----DD--LDE----GL 60
6_pfamImport    1 -REKLIRRKKHKRSSKPIKVSVwepQVSHF-------NSDMWSSKKsILNDGRSTSTEA-SED----KHtiYSK----NL 63
5_pfamImport    1 ERDMLLRYRRQDSLRRKKPFRTcrpVVETFFGYDEEgSIDSDGSSI-SYHTDR---TPC-TPD----DD--LEE----GM 65
8_pfamImport    1 ERDMLLRYRRQESVKRKRTLKAc-rVIETFYGYDEEaCADSDGSSL-SFHTDQ-------TPD----TE--PDEmgkgMV 65
10_pfamImport   1 ERDMLLRHRRQESVRRRRSFRAc-rVIETFYGYDEEaSVDSDGSSL-SFHTDK-------TPD----TE--PDE----SC 61
gi 727024559  415 ERERLLRSKKQRRKSLKPPKRH---VVETFFGFDEE-SVDSETSSVtSYNTDKTDRTPA-TPE----ED--LED----ST 479
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
11_pfamImport  67 AKEEPELRFRQLTMEYQALQRAYALLQEQVGgTLDAEREVKTREQLQAEVQRAQARIEDLEQALAKQ------------- 133
4_pfamImport   66 SREEAELRFRQLTREYQALQRAYALLQETTG-PLDPERHCRTREQLQTELIGCQARIADLERSLAEK------------- 131
9_pfamImport   66 SREESELRFRQLTREYQALQRAYALLQEQSGgSLDAEREARTREQLQMELSSCQSKITDLEKALAER------------- 132
1_pfamImport   51 TEAHNAHTVQKLLAQNEQMRLELSELRTSLAaERNAVRVLRAQN--ESDLRKTKSECKKLQEALQHQkrhsqaqcqsvsv 128
2_pfamImport   75 NANYHEPVYAQLLNDHRALQKTYNELRSKL------ESKGKELERLEEETRNATSQ------------------------ 124
3_pfamImport   62 AAEESELRFKQLTREYQALQRAYALLQEQKGgVLDAEMEAKAHEQLQAEAHRYKAKIEDLEKELSLK------------- 128
7_pfamImport   61 AAEESELRFRQLTKEYQALQRAYALLQEQTGgIIDAEREAKAQEQLQAEVQRYKAKIEDLEATLAQK------------- 127
6_pfamImport   64 AAEESELRFRQLTKEYQALQRAYALLQEHTGgFTDAEREAKAQEQMQTEVLRYKAKVEDLEKTLAQK------------- 130
5_pfamImport   66 LKEETELRFRQLTMEYQALQRAYALLQEQVGgTFDAEKELKTREQLQAEMIRYQTRIADLECVLSHE------------- 132
8_pfamImport   66 CVREAEFRYCQLTQEYQALQRAYALLTEKSGvNYDAEKEIKTREHLLAEISQYQTKIADLESALKQQ------------- 132
10_pfamImport  62 AREDTELRYRQLTQEYQALQRAYALLTETSGgPCDPEKEIKTREQLMSEIRRFQSRVSDLESALTQQ------------- 128
gi 727024559  480 PKEEAELRFCQLTREYQALQRAYALLQEQVGgTLDAEREARTREQLQADLLRCQAKIEDLEKALIEK------------- 546
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
11_pfamImport 134 -----------------------GQDMKWVEEKQALYRRNQE------LVEKIKQMEIEEGRLKHEVQDARDQNELLE-- 182
4_pfamImport  132 -----------------------GQDSKWVEEKQNLIRINQE------LREKIVSLEQCEIRLRSEVRDTLDQNELLE-- 180
9_pfamImport  133 -----------------------GQDSKWVEEKQYLIRANQE------LHEKIHVLQQTESSLQAEVQDARDQNELLE-- 181
1_pfamImport  129 gggtpakrahrggsgeheptggwGSESRGQQQQQ----QHQQqcclevL------------KLNQEISALRETNRFLEek 192
2_pfamImport  125 ------------------------NDNKNLQE-------NHEnainliMAEQIRILKEREGQLIAEAEELREQRDLME-- 171
3_pfamImport  129 -----------------------GQDSRWVEEKQLFMRRNQE------LLDKVDKLESENGKLQQELQDSRDQNELLE-- 177
7_pfamImport  128 -----------------------GQDSHWVEDKQLFIKRNQE------LLEKIEKQEAENHRLQQELQDARDQNELLE-- 176
6_pfamImport  131 -----------------------GQDSHWVDEKQLFIKRNQE------LLDRIERLESENSRLQQELQDSRDQNELLE-- 179
5_pfamImport  133 -----------------------GQDMKWIEEKQALYKRNQE------LVEKIKNMEMEETRLKNEIQDAKDQNELLE-- 181
8_pfamImport  133 -----------------------GLDVKWVEEKQALYQRNQQ------LVEKVKQMEGEELQLKNEIQDIRDQNELLE-- 181
10_pfamImport 129 -----------------------GLDVTWVEEKQALFQRNQE------LVEKVRHMEGEEMRLKNDIQDIRDQNELLE-- 177
gi 727024559  547 -----------------------GQDSKWVEEKQLLIRTNQE------LLEKIYRMEQEEHQLKNEMQDAKDQNELLE-- 595
                         250       260
                  ....*....|....*....|....
11_pfamImport 183 FRILELE----E-RERKSP--AIN 199
4_pfamImport  181 FRILELE----E-RERRSP--AFN 197
9_pfamImport  182 FRVLELE----E-RERRSP--AFN 198
1_pfamImport  193 YQISSEA----E-RQKASDirVQR 211
2_pfamImport  172 FRILELE----EcRKEFLDkeVIR 191
3_pfamImport  178 FRILELE----E-RERRSP--PF- 193
7_pfamImport  177 FRNLELE----E-RERRSP--PFN 193
6_pfamImport  180 FRNLELE----E-RERRSP--PFN 196
5_pfamImport  182 FRILELE----E-RERRSP--AIN 198
8_pfamImport  182 FRILELE----E-RERRSP--AIN 198
10_pfamImport 178 FRILELEvetkE-RERRSP----G 196
gi 727024559  596 FRVLELE----E-RERRSP--AFN 612
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