Conserved Protein Domain Family
Phage_holin_2_3

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pfam16080: Phage_holin_2_3 
Bacteriophage holin family HP1
Phage_holin_2_3 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.
Statistics
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PSSM-Id: 318330
View PSSM: pfam16080
Aligned: 14 rows
Threshold Bit Score: 55.7728
Threshold Setting Gi: 123530177
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123530177   3 DKAASAAAYASSAVATLFGL--------SLSQVVALGGLLIAAATFVMNWYYKQKHLdlaREQ 57
gi 122368685  45 EKYTSGSSYGWGAFTVMLGSl-------SLNEWAIVVGIACTVGTFTINWHYKRKEFqlrEKA 100
gi 123519864  23 EKLTTGSAYSWALVTCLLGVf-------SLSEWALITGIACTLATFLLNWIYRHKEYrfrTKR 78
gi 1708283     3 SKIDSAIPFIGSLTALISGY--------SLHEWASLFGILFGAVSVWIAYRKYKEDVqarKDE 57
gi 229465930   5 EKYTTGTAYGASATTFLCGAl-------SLSEWALVTGIICSLLTVGLNWYYRHKEYrfrTRN 60
gi 229466312   5 EKYTTGTAYGASATTFLCGAl-------SLSEWALVTGIICSVLTVGLNWYYRHKEYryrTRN 60
gi 915370      7 KNSETTGAYVGSAIAIYSGf--------TLADWAAIFGILFGLFTMLINWYYKNKEIklkETA 61
gi 502965172   6 DRVVSFLSYLPSAFLTTLGLf-------SLTQWATLIGIVLGILTYRLNKRHKRRVEleeEKR 61
gi 640469011   2 QEKSSLAAYISSGSLVVIGKigawfndlTLNEWAIVIGIIMATVTCAANIYFQRRQTraiEKA 64
gi 490358921   5 DKYSSPTAYAWGLITSAFGIl-------SLDQWAIVAGIICTVGTFLVNWYYKRKEFqlkAGE 60
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