Conserved Protein Domain Family
DUF4820

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pfam16091: DUF4820 
Domain of unknown function (DUF4820)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 320 and 483 amino acids in length. There are two conserved sequence motifs: WSLP and RPLPW.
Statistics
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PSSM-Id: 318339
View PSSM: pfam16091
Aligned: 11 rows
Threshold Bit Score: 237.008
Threshold Setting Gi: 749795152
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122063616  38 VREQAERFASTRVGQFVIERADKALAMIEDTAKWSLPQ----------------------DkSSAp--LERPLPWAPFLM 93
gi 74805126   27 LYDVVARVATTSIGQFVYKRVDNLLWTMEKTARWSLPQpspvggavsskksspeadedigS-NISgppLIRPLPWLLFLP 105
gi 121956076  25 LYDYTAQAMTTRVGNYVYHRFDTCLSVVEKTAKWSLPQsppps------------eedtsKvNISpppLIRPLPWIMFLP 92
gi 170065271  25 LYDVVAQGATTRLGGFVYRRIDSVLSTVEKTAKWSLPQpvldgg----------deassdGsKISappLIRPLPWMLFLP 94
gi 195029749  38 VREQAERFASTRLGQLVIERVDRGLKLIEDTTKWSLPQ----------------------DkNSSavvLERPLPWAPFLL 95
gi 345484822  12 MES----AAQMFIGQAFLRLIDRILWIVEKSVQWSLPSeevs--------------akenGkTFGkadLVRPLPWIIFLP 73
gi 307180019  26 LKFLQVVMVQSSLGQTILKLMNNFLWTVEKCAEWSLPDqeidl------------dedenKkKSG---LVRPLPWILFLP 90
gi 968110892  42 VREQAERFASTRLGQFVIERADRALKLIEDTTKWSLPQ----------------------DkNSSavvLERPLPWASFLL 99
gi 968087130  39 VREQAERFASTRLGQFVIARGDRALRMIEITAKWSLPQ----------------------EkNAAp--LERPLPWMAFLM 94
gi 195149919  37 VREQAERFASTRLGQFIIERGDRALRMIEDTAKWSLPQ----------------------EkSADp--LQRPLPWGPFLF 92
gi 749795152  19 IKSAVDRAARTWIGLIVLKQMDTFLWIVEKSMEWSLPRnedis-------------eneeSrRAD---LVRPMPWPLFLP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122063616  94 LIVLLRLTRIWLSVGALMIGNGPISPTDMVYFIQTRRRKLRAIRV--HGLKVMRRRQQE-------VSYGSGKGMTQKLN 164
gi 74805126  106 ALIVLRMVRSTLSLGARFIGRDPVLPSSMVGFLQNKRRKLRALKY--RGQRLQRIAKVEq------EADPKQVTWLQRII 177
gi 121956076  93 ALIALRLIRASLSLVALMIGKQPVYPENMVAFLQSRRRKLRALKY--RGQKIQRMRRAEkes-egkPEALVAKSWLEKIT 169
gi 170065271  95 ALVVMRMVRVGLSLLALMVGRPPVTPASVVHFVQNKRRKLRALKY--RGQKLGRISRAEa-----kAEDELQTTWLSRII 167
gi 195029749  96 LIILLRLVRIWLSVGALMIGDGPVAPTDMIYFIQTRRHKLRAIRV--HGLRVMRNRQQE-------MS--PGKSFTQKLS 164
gi 345484822  74 ALLFLRIIRIGLDALGAILGYPQVEPSDMVRVIQRGRRRIRAIKS--SGLKSMRLRSTPvikdramSMREASKNLAKSIR 151
gi 307180019  91 SLIILRILRMTVNAGALLIGYSQVTPSGLI-----SRKRLNDVKK--SGMKEKQnkd------ersSMNEARKALIKSIR 157
gi 968110892 100 LIVLLRLARIWVSLGALMIGNGPVSPTDMIYFIQTRRRKLRAIRV--HGLRVMRHRQQE-------TSSRTSCSYTQQLS 170
gi 968087130  95 LIILLRVTRMWLSMGALMIGNGPVSPTDMIYFIQTRRRKLRAIRL--HGLKVMRQREQE-------LQYGAGKGLTYKIS 165
gi 195149919  93 LIIMLRLTRMWLSLGALMIGNSPISPSDLVYFIQTRRRKLRAIRV--HGLKVMRQRQQE-------VSYGSGKGLTHKLT 163
gi 749795152  83 TLLFLRVIRASLNAGAFMLGLPLVSSVSMVRFVQRSRYRLASVRQgnRSRPSEKMRLKRdaqdkrlSMYQAKKALIRSIR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122063616 165 QWFSRAMC-----RPGv-----------------------QQDSSSRRVFVRHSEQ--GLSNFVVKRPR-------EEDC 207
gi 74805126  178 LPLRMVICt----RPYrtid-----------------tnsDVAHAVIFRKDRPASSagQKRVESKKRNLnqreaesEEEE 236
gi 121956076 170 LPLRYMIClr-avRPGssihqkehhhhhhhrqgqsrdsnnEAAN-------KDGAKprDESARRRKRNAherdaddSESS 241
gi 170065271 168 MPLRTIVC-----RPGr--------------------------------vVRQQNQqqDQQQPGRKRNAqerdvddDDES 210
gi 195029749 165 LWFNRAIC-----RPGv-----------------------QRENSGRAFNMHSSDQq-PANQSVTKRSL-------EDES 208
gi 345484822 152 LTLSTLSCldsasKTSpspppt------------kirvsnILDAAVPPMSEETSGIdsAVGSPNQDYSKrkyseigTDES 219
gi 307180019 158 LTLSSLSCld-msKPTpspppt------------kihvssVLDPDAPTTT--TSEEksATESTDATEKQenltscsESSS 222
gi 968110892 171 QWLSRAIC-----RPGv-----------------------QRANSGRVLNLRDMEKpqQGNQLNNSVSKrp----rDDDS 218
gi 968087130 166 QWLSRAIC-----RPGv-----------------------QRANSGRLFTV-NSNS---LEQNVSKRPR-------EEES 206
gi 195149919 164 QWFSRAMC-----RPGv-----------------------QKANSGRLFQVRNMEQttQTSPAVMKRPR-------EDET 208
gi 749795152 163 LTLSTLSCld-gsKPSlspppt-------------rihisALDLDAATITGGKSATesAMSPVLEEKQReeptsatKSDI 228
                        250       260       270
                 ....*....|....*....|....*....|.
gi 122063616 208 NA----DADLTIDQMLAKYAnensedDSDFV 234
gi 74805126  237 CSdeysFEDAGCKELLDKYAne---eDSSFN 264
gi 121956076 242 V-------DATVQELLEKYAde--egDSSFH 263
gi 170065271 211 GPe---VDEGTVSELLDKYAdd--agDSSFH 236
gi 195029749 209 NE----DDNLTIDEMLAKYAnqnsedDSDFV 235
gi 345484822 220 SLd--eSDEETLISKINRLAnas-dsDKDFS 247
gi 307180019 223 SEdeknEEEETLKEKIDRLAlessdeDEDFD 253
gi 968110892 219 NP----DQNLTIDEMLAKYAnensedDSDFV 245
gi 968087130 207 QTe--aDHNLTIDEMLAKYAnvnsedDSDFV 235
gi 195149919 209 NTdletDHNLTIDQMLAKYAlensedDSDFV 239
gi 749795152 229 TEteteTETEAELGRNEQLVd----tSHDVT 255
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