Conserved Protein Domain Family
DUF4855

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pfam16147: DUF4855 
Domain of unknown function (DUF4855)
This family consists of uncharacterized proteins around 400 residues in length and is mainly found in various Bacteroides species. Several proteins are annotated as glycerophosphodiester phosphodiesterases, but the origin of this annotation is not clear.
Statistics
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PSSM-Id: 318392
View PSSM: pfam16147
Aligned: 29 rows
Threshold Bit Score: 334.988
Threshold Setting Gi: 754214502
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81445455    39 DLALIYQG-GVHR--I--------D------WTSDQFLPYVVHQFADGH-K--DWLFDGFLFLEFTD-----GkG----- 88
gi 506214129  224 DLSLLYNG-HYAN--G--------Dg----dWSKEEIIPQISYVDQNGEpV--DWFFDGVLTLGLIS-----PdG----- 276
gi 752665382  493 DILLVYTG-HHGKa-G--------T------WTSDDFLPMIAYRNRQGY-R--DRMFDTMLFLP---------------- 537
gi 502527368  488 NILLIYTGdKSKK--A--------D------WTAGDFIPVVAYMDENRRiK--GSMFDTMLFLPYS-------------- 535
gi 502884082  488 NILLVYTG-KQDY--Aq-------T------LIGEHFLPLVAYIDRQGKiK--GRMFDTMLFLPYS-------------- 535
gi 524579893  186 stVIIYNG-YWDS--TmnysesyvR------STAEMLLPYVGYIGGDGEvY--DTMFDSVVFLLLQSrspsgGkT----- 249
gi 524580278  222 NIVLIYNG-KYYN--G--------TvneigsHSADKMLPLFAYVDKTGK-NysDTLFDSCLFLPLAP-----GdT----- 279
gi 502570238  282 NLNLLYNG-QYANglG--------D------WKKERIIPNISYVNKDGEpV--DWLYDGVLYLGIAS-----PaGrd--- 336
gi 506215647  229 NLGLLYNG-HYADgtG--------N------WTKERAIPNISYVNEQGEpV--DWLFDGVLYLGLTS-----DnGrgfga 286
gi 506373980  550 NMLLAYTG-EHNEl---------gT------WTKEDFLPMVGYRTVDGYmR--DQMFDTILFLPYQ-------------- 597
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81445455    89 CGFAtrySD--KNARKKEWLWLLDRLFED--GKALSALDRCIGTQIKEIG---KPD-FTHQIVLCLPEVLPGQKDWGEVD 160
gi 506214129  277 RDF-----G--GGANLQDWKWYLDKTFDA--DGEMHQLNEATKEVGAKLG---QPD-HKTKVVVMIPDTGEYQTDFGDVD 343
gi 752665382  538 ---Y---RE--TGSVKEKWIAYLDDLFTP--GIQLSALNEAVAEMNRILG---T-A-HTVKVILTLPYPDSQERNFGNLA 602
gi 502527368  536 -------FE--ITCTKESWNAYLEDLFNP--VKQLNALNLAVGQINQITG---QQE--KEKVILSLPYPSVDQQDFGQLD 599
gi 502884082  536 --------G--YPCTREHWQAYLEDLFAP--GRQLHALDDTVEKVNQITG---KP--QKEKVILTIPYPDPNQSNF---D 595
gi 524579893  250 VFFS---NGdgNATVKSDFDYFADNLFAN--GVNMDALDEAFGIVKKQLNl--SDD-RKLNVSVQLPYVYKTDLPFGDIN 321
gi 524580278  280 ---D---DG--SFRTQKGWEAYLENTIGAddGVNLTALETLVGTIKEKLS---LPDdYKVNVFMTIPTITRASRAFGTLD 348
gi 502570238  337 ------fgQ--GQTNLDDWKWYLDKTFAA--TGDMQQLNEAAKEVGAKLK---QPD-HQVKVVLMIPNPGESLTNFGDID 402
gi 506215647  287 AEA-----A--GKARKQEWEWYLDKTFNA--GGDMSALNEATVEAGVKLG---EPN-HKTKVVLMIPEPGEYQSDFGSID 353
gi 506373980  598 --------T--IPATKESWTKYMNDLFGS--NKQLDALNQAMREYNRLRGtlySTP-TQENVVLALPYPNANQTNFGQLD 664
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81445455   161 GEPMDFSR-----Q----------E---------DQVKATRWYIDELMKRFKQAKYKHLKLSGFYWLAEDI-----DFTK 211
gi 506214129  344 GDGISENF-----NagavgeesamA---------NRQKAIRWWMDEVLQRWEANHYSNLELVGLYWLSEQVst--sASGP 407
gi 752665382  603 EKSPSLSF-----Dp---------AhvgreqalaNRLAALKWYYKELNERWQAARFDNLELAGIYWYAETIdg-hiPDET 667
gi 502527368  600 KNEPSLSF-----SetqlgkeqaeK---------NRFAAVQWYYNKLMEKWQQADFKNLELIGIYWYEESVdyhniKSET 665
gi 502884082  596 GISFSETNtgkeqAa---------K---------NRFEAVLWFYSKMMDKWSDARFKNLELVGVYWYKELVdk-svYREV 656
gi 524579893  322 GDGADEKA-----Et--------pD---------ERLAIYEYYVDMISARFASRDYKNITLAAFYQGCEGVpvamsDDEY 379
gi 524580278  349 GTSRIAPN-----Nl---------E---------NAKKIVKWFVDLSASEFEKQNFKHLNLTGFYWYSESVayssaAYDP 405
gi 502570238  403 GSG-SLNF-----NdsvvgkekasE---------NRGKAVQWWLDQTRQRWQAANYSNLELVGMYWMPEQIdi--sESGP 465
gi 506215647  354 GE--DLNF-----DvgavgdaaslD---------NRAKAIQWWVDEVQARWTAAGYSNLELVGMYWLEEQIst--hTTGP 415
gi 506373980  665 EKKPSLSF-----NpagigeeqayL---------NRKAALEWYFQELMKRWNREGYAYLKLEGIYWFHELVed-saPKER 729
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81445455   212 DLSVPLSKYIHSKNKTFCWIPYWQAKGYNQWRELGFDIAYQQPNHFFKa-SIPD--KRLE----EACQSAATLNMGMELE 284
gi 506214129  408 DMLKYVNGQIHVEGLKSFWIPHFLAYKSYMWEEVGFDAVAFQPNYFFe--DMSS--ERLD----DAAYTAKRFGMGVEIE 479
gi 752665382  668 QLVQGAARIVRADNRDFYWIPFYGAKGYENWRSYGFEYVLLQPNYYADe-IKPD--ERMD----RTAALAKKYRLGMELE 740
gi 502527368  666 ALVQKTARLVQDNKLKFFWIPYYGAIGFEDWKKFGFDYAFIQPSFYNSe-QLPI--ERMD----KAAELARKYNMGIEIE 738
gi 502884082  657 ELVQNVARMVSEKGQKFFWIPYYGAQGYESWKSYGFTHVFLQPNYYATq-APSE--DRME----RAAALAQKYGTGIEIE 729
gi 524579893  380 GLFRLVNEMLHKKGFRATWIPCFLGTGFDRWKELGFDYAYLQPNYMFHd-WQPD--S-LA----EFAEIIGKYGLGAEIE 451
gi 524580278  406 DLIRYFTSYCHSLDHAAIWIPFYGAPGFWEGNELGFDVAALQSGYAFPgnGDSEvgSPLKgtcyDSMSIAKKYGMGVEIE 485
gi 502570238  466 DIARMVSDKVHAMNMKVFWIPHSYAYKMFMWKDVGFDAAALQPNYFFg--GMDS--DRLD----DATDTAKRYGMGNEVE 537
gi 506215647  416 EMVKRSSDIVHNAGLKLFWIPHFMAYKAFMWKDVGIDAVSLQPNYFFe--SLDP--SRLE----DTADMAKRYGMSLELE 487
gi 506373980  730 QLIRDMGSMVHDEALRYYWIPYFGSPGVSEWKSLYFDKAFLQPSYYSDk-PVGI--DRIQ----GVLEVVNKYNMDIEIE 802
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81445455   285 FDERAL--FDAkd-sfYNRLVAYIDHFERQQA-FRTSAMAYYS--G-N--H-AVLDMYKSTNPKDHEVMDRLAN 348
gi 506214129  480 FDGRML--TDEv---fRNRYKEYLDGGVKYGY-MNDTFKAYYK--G-S--GpVLRDAAASQDPDIRIMYDWLYQ 542
gi 752665382  741 ISDQVF--DSVs---hYNAFYKQLDRAHQLGV-DGDMTNAYYA--G-S--K-TLVRVSNSSDPKIRAIYDDLYR 802
gi 502527368  739 FDDEIL--NGDy---fNDLLHKQLDKAHQLGLdDSKTTRAFYM--G-L--R-AIVTCSRSNQPQARATYDLLYK 801
gi 502884082  730 LDSRIF--SDPy---yYTLFYKELNKAHQIGL-DRHTPKAYYV--GqV--W-TLLAAASSIYPEQRQVYDDLYK 792
gi 524579893  452 INHTCVlpKSPlferdRQKYIDYLDYGAKYGY-M-NAALAFYQ--G-AgpG-SMYTAALSGDWRVRNLYDRTYR 519
gi 524580278  486 L--QLV--SDA-----PERYSDYLAQSYKLGC-MQNGVSMYYQqgG-E--G-DFSRAAASTTAKVRNIYDMTYK 545
gi 502570238  538 FDDGML--TDPv---lRQRFVEYLDSGVRSGL-MQNGFRAHYQ--GnN--A-VY-NLGVSKDPSLRLMYDWLYQ 599
gi 506215647  488 FDDRMI--NDAv---fRERFIEYLNSGVDTGL-MQHGYKAYYQ--GnN--A-VY-NAAKSTDPATRVLYDWLYL 549
gi 506373980  803 GDWKMY--NDPk---fYQTYYNQLVATHKLGM-DKNNVHAYYF--G-S--K-TLLESVKSTDPVKRAIYDDTYK 864
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