Conserved Protein Domain Family
DUF4868

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pfam16162: DUF4868 
Domain of unknown function (DUF4868)
This family consists of uncharacterized proteins around 320 residues in length and is a phylogenetically broad range of bacteria associated with the human gut microbiome. A member of this family from Lactobacillus casei CRL 705 is part of the gene cluster involved in synthesis of bacteriocin toxin, but the specific function of this family is unknown.
Statistics
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PSSM-Id: 318407
View PSSM: pfam16162
Aligned: 16 rows
Threshold Bit Score: 128.177
Threshold Setting Gi: 501689206
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122149701 115 KLNFYCLNIKFEENNQ----E----KEINFFRRVTKFKKLsskgFMGFI----KNNRF-K-KLDSNLLGLDGFIDIAIY- 179
gi 81732278  121 LEKVKGMVIKLTDGNT----NlylyQHKFPIALHRKSK------LSFMS----TQRNIlK-RVGHDVIDINKNIDFFMY- 184
gi 493567957 120 RDNALGLLFMFRRGDNkiwgY----QHIYTVTIPNKLRKN----WLSIQ----QAETF-K-EMILPLFPIAKKVNLIII- 184
gi 524413891 134 RDKADAILFRFRRGLHsiwaY----QYILPATIPNKKNQH----FFARIldteQTDCF-V-EMPEQLFVITRKVDLLII- 202
gi 295100483 111 RNKLSGFLFKINLNDQyfwvY----QHIYSISRIDRSKNV----IALFI-----GDTY-D-EVDSDIVQIDSRADIIIF- 174
gi 502248989 113 IGNVLGFLFKINLNSKklfiY----QQAYVGSRL-QAKNN----LRIIQ----KDNVF-E-IVDKEMLKIDKRGELLIL- 176
gi 502390574 115 IGNIKALLIEIGNNEKqvilY----KTIAPIHIFSQSS------FCLVQ----HETRL-E-KIDKDFLRISPGFQMLKI- 177
gi 506331571 109 LQNTKYYCVKFKIKSGfihaF----KWIGATWSTKNTS-Y----ASMFI----NEGSL-KqLEEDHSFRVTKNFDVIVM- 173
gi 501689206 112 LEQVWGYVVRIECFTKtlflF----KKYTPNKLLVKGKKL----LRM------QDGQF-T-NLNTQIITIDSSYDAVLLi 175
gi 643492523 112 qkdLYCIKIEIEAG-----------KYAYFLNRIPQFKKFsk-gLWGII----ADTTF-R-KVSDSFIGIEPGFDLLIY- 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122149701 180 -----------GQDVLIFNHISLERIFSIADQYLEKAQNTIDIIRDINRID------NFEQFEE--D-ClNDRRITRTLT 239
gi 81732278  185 -----------NGVHYIVNVKRLEASYGLDAVINNMVNQVIPLIVSLNVIDmsahanPLEIFDDl-K-K--NKSSMRKIA 249
gi 493567957 185 -----------GQEITTKDISLMQRQFGFETYIRNSAQTVIGDVSEIGLFE------NIEKLSSy-V-ErSKLTYAKKMM 245
gi 524413891 203 -----------GDTIVTKDIGLMQRHFGFNDFIKASAKKAVSDISDIRLVI------NCEKLTAy-I-ErNQTKYSRKMM 263
gi 295100483 175 -----------SSSAVTAKMDLMQRFFGFEQYIRAGAQKTIEIIRNLDIVD------SLEKFVAfeN-K-SKLTNAKKLL 235
gi 502248989 177 -----------DNTILVRNVKVLQDFFGFQVFVRNQAQSVISKLEELDIIG------NIATLKEy-QtG-EKLTISKKLM 237
gi 502390574 178 -----------DGELLVNDLAALERSFGFHEIIKKEATLGITAIEDKLVIE------NVEALREl-L---EDIKYARRFV 236
gi 506331571 174 -----------DNIEYIINFNPYSQIFDYKENLLEVADSAYTELIDLGVLT------SSEKIKKy-V-G-NNSMRLKRLS 233
gi 501689206 176 essteisqkipSSDVFVLSRASFESFFSFVEIYKSEVEANKKYLIEKSLLN------NVTLLIEn-C-I-NDGRKIRKLA 246
gi 643492523 173 -----------DNEILVVNNVSVQRIFDLKTKYVHNTNSVLCAFEETNKLE------GFEQFKN--D-SiEDGNIVKRVS 232
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 122149701 240 KMLSEEArlencFD---NFANVVNAIDLFQ-LDINIDRNgeRDKVIYENKEqLMDIIRLVRDSYYKSII 304
gi 81732278  250 KILNGRIls-vgLT---IPQIINVCNDFPV-FSRGITFS--NNFVDLSSQKkKLIFIRMLNDEAVRSAL 311
gi 493567957 246 RIRHSAVl---rMS---SEQLLNKVQTLPR-WSGKFVIE--NNRIVLKTYNhVENLIDLLDERYTRSDV 305
gi 524413891 264 RIKHYHVv---eKT---AEELIQRVNTVPR-WQGVFDIR--GGQIYLHTFRdVENLIDLFDERYTVSLV 323
gi 295100483 236 KAKNSPVl---qMK---KNDLLENLKKHSR-YKTMFKFE--EDHIVISSQKeAAAFIKMLNDDIVRSEL 295
gi 502248989 238 KVKNSPVl---aMD---KDELINKIPLVPR-YKNIIHIE--NGKIRTNTKKdVDNLMKLLNDDYVKSEL 297
gi 502390574 237 KVAKGSPv---lIKnipNTSIISFCKTFPA-LAGRIRFNqaEDKIVLDSKVsKDLFIKLLMDNFLTSDL 301
gi 506331571 234 EVVAKGF-----YA---QEKFMKNLKANNKeLKFNFKFV--GDKIEPEENK-ISELLTALGDRRLTSmn 291
gi 501689206 247 RIIKNDQl---------QSITIEKIKKMVQdYNLDIYFDa-TGKIEFTPEK-IWVFLRIFDDDYVKSEI 304
gi 643492523 233 RLMTKPErmtrfVE---NFDKIEEIIKEF---DLNIELNeeKSKIKYTDKKqLNDIVKLLNDAYYKTVL 295
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