Conserved Protein Domain Family
AC_N

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pfam16214: AC_N 
Adenylyl cyclase N-terminal extracellular and transmembrane region
This family covers the N-terminal extracellular region and the first transmembrane 5-6 pass region of adenylate cyclase.
Statistics
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PSSM-Id: 318454
Aligned: 3 rows
Threshold Bit Score: 705.229
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O95622          1 MSGSKSVSPPGYaaqktAAPAPRGGPE-HRSAWGEADSRANGYPHapggSARGSTKKpggavtpqqQQRLASRWRSDD-- 77   human
XP_020568499    1 MSRSNSVSPPGV-----GAPGLRGGTE-HRSAWGEAESVANGCPY----SVRSPRKK---------LTRTNSRWREEDep 61  
NP_989962       1 MSRSNSVSPPGF-----GGPAPWAATEqHRSAWGEAEARANGYSYpp-pPNRSSGKK---------ASRMASRWRSEE-- 63  
O95622         78 DDDPPLSGDDPLAgg-fGFSFRSKSAWQERGGDdcgrgsrrqrrgaasggstrappaggGGGSAAAAASAGGTEVRPRSV 156  human
XP_020568499   62 DNRPPGRASTTVS----RVSFRSRSAWQDHGEE--------------------------KPEDNRASAKRTEGEVRPKSV 111 
NP_989962      64 DYEPQASRSRGESgckmMMSFRSKSAWQEHGDEsrrhrsr-------------hppggdSPAAPNNASPREQGEVRPRSV 130 
O95622        157 EVGLEERRGKGRaadeleagaveggegsGDGGSSAdsgsgagPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFR 236  human
XP_020568499  112 ELGLEERRLKSR----------------GDEEEVM-------PEVNFSLVACCVGVMHIFKSKKFQSEKLERLYQRYFFR 168 
NP_989962     131 ELGLEEKRIKAKieel--------eeddGDDGD---------SEVAFSMGSCCSSLLQIFRSKKFQSEKLERLYQRYFFR 193 
O95622        237 LNQSSLTMLMAVLVLVCLVMLAFHAARPPL--QLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQV 314  human
XP_020568499  169 LNQSSLTMLMAVLVLVFTVMLAFHCAGGPAgpSVTYVVVFSLAIFLTLVLMVICNRNGFHQDHMWVVCYVVILVVLVIQV 248 
NP_989962     194 LNQSSLTMLMAVLVLVCVVMLIFHAVHGHY--EVSYVVVLSLAILLMVVLCMVCNRNDFHQDHMWLACYSVILVILAVQV 271 
O95622        315 VGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGV 394  human
XP_020568499  249 IGVLLVQPRSASEGIWWTVFFIHVIYTLLPIRMRAAVITGVILSAIHVAVSWMLNGMDSFLWKQLVSNVLIFCCTNIVGV 328 
NP_989962     272 VGVLLVWPRSASEGIWWTVFFIYSIYTLLPVRMRAAVISGVVLSAIHLAVSLKINAEDKFLLKQLVSNVLIFSCTNIVGV 351 
O95622        395 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFH 458  human
XP_020568499  329 CTHYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKDDINAKQEDMMFH 392 
NP_989962     352 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFH 415 
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