1R4X


Conserved Protein Domain Family
Coatomer_g_Cpla

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pfam16381: Coatomer_g_Cpla 
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Coatomer subunit gamma-1 C-terminal appendage platform
Coatomer_g_Cpla is the very C-terminal domain of the eukaryotic Coatomer subunit gamma-1 proteins. It acts as a platform domain to the C-terminal appendage. It carries one single protein/protein interaction site, which is the binding site for ARFGAP2 or ADP-ribosylation factor GTPase-activating protein. COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER and intra-Golgi transport. The gamma-COPI is part of one of two subcomplexes that make up the heptameric coatomer complex along with the beta, delta and zeta subunits.
Statistics
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PSSM-Id: 318574
View PSSM: pfam16381
Aligned: 69 rows
Threshold Bit Score: 87.255
Threshold Setting Gi: 123363161
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1R4X_A        162 ADHIQKVMK--L--N--FEAAWDEVGDe--fEKEETFTLs-TIKTLEEAVGNIVKFLGMHPCERSDkVPDNKNTHTLLLA 232
gi 122096156  735 ADFIQEYHV--E--N--WNEEWNNIPVq--nEKKTVIKFp-NVSTIKEAVEKIKLHFDLRVVDGSDvVSEGARKHILYLA 805
gi 122096157  729 SDFVSPVEI--E--D--WNVQFESLSKe--aNKTQIFKFp-AFKNLQIAVDKLKELFGLNVINGSDdAKKAVKKHVLLLA 799
gi 122111640  761 SDFITPIDL--Ge-C--FQQKWEELRQe---ETCGTYALs-SMRNLTAAAHELVEFFGMHVVGGKVdKITAAS-HTLLMS 830
gi 74778737   817 SDCIIPNYL--RqgE--FKNVWNILETsg-iEHIAKFSF--SYKNIPSAVNGLLALVNAAACDNTEnVNLESSNHTLLFS 889
gi 294947350  879 GDHISPRGL--P--SgqFRQGWEAMHAqgggETTAKHIL--AYKTLEQAIKGIQTSLNCEPCDGSGnTNTAARGHTLLLC 952
gi 209879836  791 NDYILPNALrfG--E--FKNMWYILEThg-fEVIAKFAFs--YKSISSAIDGLLNLTNSYACDNTEdIRPEAKNHTLLFS 863
gi 290974281  783 TDFVRNMAV--S--S--FKEEWDKLGEe--sEFAQQPIEytASDDLQAAVDKFISSVGLRPIGDRTv---SKKTHSLYFA 851
gi 123363161  169 efWCEPISV-----D--FEREWDNEQYi---KCTKAFVMs-NDKDTESAVKRIEDDFSWLHFVCKGeNSKNTAI-ILDFS 236
gi 954273493  455 NMQVKPMMK--M--N--FNAIWEDLDGn--aEVACTYSLp-GYGSIQDAIDKILDCLGMAPCDRSEkASKNKGAHVLLMA 525
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
1R4X_A        233 GVFRG-GH-DILVRSRLLLl--DTVTMQVTARSLEELPVDIILASV 274
gi 122096156  806 G--MMkGE-VVMIRVRLMIdktNQVPIEVCIRSPSLELSQSLYETL 848
gi 122096157  800 GNILLkEPaTTFIRLRMLCd-eKGVTVEVCIRSTNTLIPDMLLALL 844
gi 122111640  831 GSMVDgASsLVMINARLFIatdNTVALQLTLRGGSSELREYLSGAL 876
gi 74778737   890 GTYFA-KT-PFLCTAIIVNnaeLGCLVKITCRSNSESVCLDVIKCF 933
gi 294947350  953 GTFAG-GM-TVLVKCLLGIdpsRGCLLKLSVRAKSQAVTELVARAI 996
gi 209879836  864 GSYLG-SY-PFLGIAVIVYnveYGCLVKITCRSKDEAICHNVIKCF 907
gi 290974281  852 GKSIF-GD-MVLVAAQLGek-nGSILLKLSVRSQG-DLRESIVQQL 893
gi 123363161  237 GQMIDnGP-FVLVRTEVGSsksKGIICRVTVKTSSNDLCQKLIHSF 281
gi 954273493  526 GMFRT-GS-MLAAQAKLALapsGIINVNLSVRSEDELAVGVIVSAF 569
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