4B8B


Conserved Protein Domain Family
CNOT1_HEAT_N

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pfam16419: CNOT1_HEAT_N 
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CCR4-NOT transcription complex subunit 1 HEAT repeat
This domain is a HEAT repeat found in fungal CCR4-NOT transcription complex subunit 1 at the N-terminus of PF16418.
Statistics
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PSSM-Id: 318601
View PSSM: pfam16419
Aligned: 26 rows
Threshold Bit Score: 227.119
Threshold Setting Gi: 575509775
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4B8B_A         19 LRNFFLQTTPE--TLESN--LRDLLhSLEGESLNDLLALLLSEILSPGSQNLQ--N-DP-TRS--WLTP-PMVLDATNRG 87
gi 74602266   230 FKELLLEIGPE--HLLPEklLPSFL-QLKPTEIDQSIALILAEILIPGSQGLS--N-TNgGVT--GLTLaNNLPEANAKG 301
gi 150864806    3 FKELLSEIGPE--NILPDklLPALL-QIKPNEVDQSVALLLSEILIPGSQGLP--S-S--------LTFvNNLPEANAKG 68
gi 354542903    3 FKQLIQEIGFE--NVLPEklLPSLL-QIKPNEVDQGIALVLAEILIPGSQGFE---------Y--KVTP-LSLPESNAKG 67
gi 149236551    3 FKELITEVGFD--DLVPEklLPSLL-QIKPNEVDEGIALVLAEILIPGSQGI------N-KNA--HLQQ-QTLPEANAKG 69
gi 448123806    3 FRDLLLEIGPE--RLLPEklLPTLL-QLKPSEINSSIALLLAEILIPGSQGLS--KvDG-GAT--ALTHvNSLPEANARG 74
gi 927380699  249 FREVLQNFEPS--KLLPNkmLTDLLaAQPQTQLDEAIAILMAEILYPGSQKLCgaN-TD-PIT--ALTP-ASVPEATARG 321
gi 254573504    3 FKQSLLSQTPS--SITPSqfLADLI-SQHSNEQKNVLALLFAEILVPGSQHIS--S-ST-STKttALTP-STLPEATARG 74
gi 575509775    3 FKELLIEVNKDlkGINPGnlLPVML-KIDKKEIDSSLALVIAEVISPGSTNLP--S-NP-LKG--LSTC-KSFPESSAKG 74
gi 260942054    3 FKEIITEVGPE--KLLPEklLPSLL-LIKPEETDQGIALILAEVLIPGSQGLS--T-TNgGVT--ALTFvNNLPEANAKG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4B8B_A         88 NVIARSISSL---Q------AN---Q---INWNRVFNLMSTK--YF-L-Sa--PLMPTTASLSCLFAALH-DGPVIDEFF 145
gi 74602266   302 AQLQACLRSI---Dsd---fKF---N---IDWYKVFSHVQEN--LF-DsSk-rNLQPSVANITQLLSSLDfKVGIIDVFL 365
gi 150864806   69 AQLQACFRSI---Egt---nNF---A---INWYEVFSHVHQN--LF-D-SqqrNIQPTVTSITQILSSLDfKEGLIDIFL 132
gi 354542903   68 AQLQACFRAIeqsE------SL---S---INWYEVFNYLQQY--LF-EsSq-rNVVPSAASVSQFLSSLDfKPDPIDIFL 131
gi 149236551   70 AQLQASFRAI---EaqlgtnKL---S---INWYEVFNHMQQN--LF-E-AgrrYKLPTAVSLTQFLSSLDfKQEPLDIFF 136
gi 448123806   75 AQLQACFRSM---D------KD---QsfvIDWPEIFTGLKES--LS-EcEk-kNQQPSIISITQFLSSVDyKDQVLDVFL 138
gi 927380699  322 AQMANIINRL----------KT---Q---PNWQNVFNLVLKN-------Tl-tATSMTTASLSEFLSALE-KEDLIDLFL 376
gi 254573504   75 SQFRSLLKGL---N------IE---Q---STWDQIIELIFETddYFsD-At-sISQVTVASISQFLASLE--PENIDKFL 135
gi 575509775   75 AQLQTTFKLL---D------SDpaiK---IDWLLVFSKAQET--L--S-As-kAVAPSFLNINQFIAAIDfRPGLLDIAL 136
gi 260942054   75 AQLQTCLKTI---Dts---pAH---T---VNWFNVFAKVHEF--LF-DaSk-rNSQPSVASLTQFLSSLDfKSGLIDIFL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4B8B_A        146 SC-------DWkvIFKLDLAIQLHKWSVQNGCFDLLNAEGTRKV------SE-----TI--PN------T---------K 190
gi 74602266   366 NF-------DW--WFSKTLLYILKTLDPQQGGYDVTALKNITLCfd---nDDdn-dnDN--DD------Nkqp----qqR 420
gi 150864806  133 NY-------EW--WFNKTLLYLLQTMDPQQGAYDITLSKNVSFC------FE-----DD--KN------SqstpqqasaR 184
gi 354542903  132 NY-------EW--WFGKTLLYILQTCDASQGGYDIALSKNLSLCfeedraTL-----GQ--PQ------Lg--------G 181
gi 149236551  137 NN-------DW--YFDKTLLYLLQTADPAQGAYDISLLNNLALCf----eED-----KAtpPQ------Pg--------R 184
gi 448123806  139 DR-------DW--WFNKALLYILHSLDPQQGAYDLASSKHLTLCfd---dDY-----EE--TNfanskpLl--------K 191
gi 927380699  377 STac----kSVnpQLLKDLLIQLNSLDPSQGSINLLDY-NLEPI------LS-----SE--VN------S---------R 423
gi 254573504  136 RYvahhklkDHpfLFQKNLLVSLYSLNPQHGAIDLLSCP-LQPV------LA-----NE--PN------S---------R 186
gi 575509775  137 SV-------DW--SFSNVLLYTLLTADPKQGCYDLGTSPFLTRG------FDdvetpIE--SQ------Lg--------R 185
gi 260942054  139 SY-------EW--WFDKTLLYMLQSMHTQQGAFDIIHSKNLTLCye---eEIdda------------------------- 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4B8B_A        191 QSLLYLLSIASLNLELFLQRE-------E----L---------S----------DGPMLAYFQECFFEDFNYAPEYLILA 240
gi 74602266   421 RNILRFVNIGKLELLVLTKVS-------Q----Q---------NqqtqnqvpekERKLNIYLSQVFEHDYRVYPEYLIAA 480
gi 150864806  185 RNILKFVSIGKLELSVLTKIQqqqsqqlS----E---------P----------ERKLNLYLNHLFEHDYRSFPEYLIAA 241
gi 354542903  182 RNILKFINVGKLELQVITKVQ-------A----Qqvqq-nlseQ----------DRTLNSYLSQVFEHDYRVFPEYVLTA 239
gi 149236551  185 RNILRFINIGKFELKALSGAQ-------A----Q---------Qvtkh--lnekEVKLNTFINQQFDHDYRVFPEYVLAA 242
gi 448123806  192 KSILRFKSVSKLELRVLGDIS-------E----QnqqqqnlsdQ----------EKKLNIYLGQLFEHDYRVYPYYLVAA 250
gi 927380699  424 NLLLYFKSIVKIEVKTIALL-------------Q---------N----------ENINDSVVSNIFARDYRAAPEYIVLA 471
gi 254573504  187 RTIIWFKYIAELEVSLLVELK-------S----R---------P----------ATADENQINEIIEDSYKTAPEYLGLA 236
gi 575509775  186 RTPIAYINVGRLELKVVSQYA-------AskkpL---------N----------EKSIDSEISKLFDHHCHTFPEYMLCA 239
gi 260942054  182 peLLSFINIAKLEVQVMAKIN-------S----Q---------TaqqikmqsegDKKLDTWLSQFFDLHCRSEPHHVIAG 241

                  ..
4B8B_A        241 LV 242
gi 74602266   481 AL 482
gi 150864806  242 AL 243
gi 354542903  240 AL 241
gi 149236551  243 AV 244
gi 448123806  251 SL 252
gi 927380699  472 CL 473
gi 254573504  237 AL 238
gi 575509775  240 CI 241
gi 260942054  242 AL 243
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