4HPM,4HPL


Conserved Protein Domain Family
PUFD

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pfam16553: PUFD 
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BCORL-PCGF1-binding domain
PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Statistics
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PSSM-Id: 318702
View PSSM: pfam16553
Aligned: 16 rows
Threshold Bit Score: 161.343
Threshold Setting Gi: 780001019
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HPM_A           5 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTP----- 79
gi 556964624  1491 spFLFEFSDKPLLPCYNIQVSFSRGPCNWLLLSEVLKKLKLSARIFQARFPHFEVVSIAETEFHKQVSTSQLLHQ----- 1565
gi 847153546  1391 DNFLFEFSDRPLLSCYNLHVSLTSGPSNWLLFSDVLKRLKLSSRIFQARYPHFEIASMQKKEFTKQVLTSQLLTP----- 1465
gi 542172947  1386 DCLMFEFSSEPLLPCYHVQVSLTQGFCNWFLLTDVLKRLKMSARIFRARYPHLEVVSLSHAELWRQVSVSQVSSAlaspy 1465
gi 1020980284 1469 DNFMFEFSDKPLLPSYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEVATLPRAEFQRQVSLSQVLAQ----- 1543
gi 637351469  1394 DRFVFEFSDKQLLPCYNLQVSVSRGPCNWFIFSDVLKRLKLSSRIFQARFPHFEVATLPKAEFQHQLSLSQVLAP----- 1468
gi 941779885  1370 DCLVFEFSSEPLLPCYHVQVSLTQGFCNWFLLTDVLKRLKMSARIFRARYPHFEVVSLSQAELWRQVSVSQVGFP----- 1444
gi 528500512  1381 DCLLFEFSSEPLLSCYHVQVSLTQGFCNWFLLADVLKRLKMSARIFRARYPQFEVVNIAQAELWKQVSVSQTCSP----- 1455
gi 768910218   218 EVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLRRLRMSARSFRQAFPHMEVVTVAEAEFYRQASLSQLFSC----- 292
gi 47214458    219 EVFEFELSDRPLLPCYNVQVSLSQGPRNWLLLSDVLGRLRMTSRSFRRLFPQLNVQSVPEDEFYRQASLSQLLTG----- 293
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
4HPM_A          80 ---A--ERPGGLDdr-spPGSSETVELVRYEPDLLRLLGSEVEFQ 118
gi 556964624  1566 ---P--EDLHLSN-----PKSCNSVELIRYVPELLHLLGSTVEFL 1600
gi 847153546  1466 ---T--EGLDLWP-----QDMGDIVELVKYEPELLQLLGSAVEFQ 1500
gi 542172947  1466 kskT--KEEEKEE-----EDEDGLVDLVRCVPELQRLLGSSIHFL 1503
gi 1020980284 1544 ---E--EVPASPEp---aPGAAETVELVHYEPELLQLLGSAVEYQ 1580
gi 637351469  1469 ---E--EIQEHMVp----PGAAETVELVRYEPELVRLLGSEVAFE 1504
gi 941779885  1445 ---R--KRGGGGDdeeeeEDEEGPVELVCCVPELQRLLGSSVHIL 1484
gi 528500512  1456 ---P--DELQPEDd----EDGEETVELVRCVPELQGLLGSSIQIL 1491
gi 768910218   293 ---P--EELEGFH-----PDSKDLLDLVEDSTELATLLGSTLECL 327
gi 47214458    294 ---PdeQELASFR-----PDIKDPLELVEATPELAGMLGSSLDpe 330
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