Conserved Protein Domain Family
GramPos_pilinD1

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pfam16555: GramPos_pilinD1 
Gram-positive pilin subunit D1, N-terminal
GramPos_pilinD1 is the first subunit domain of Gram-positive pilins from Strep.pneumoniae. There are three major pilin subunits that form the polymeric backbone of the pilin from S. pneumoniae, constructed of three Ig-like, CnaB, domains along with a crucial N-terminal domain, D1. The three IG-like domains are stabilized by internal Lys-Asn isopeptdie bonds, but this N-terminal domain makes few contact with the rest of the molecule due to the different orientation of its G beta-strand. Strand G of D1 also carries the YPKN motif that provides the essential Lys residue for the sortase-mediated intermolecular linkages along the pilus shaft. Gram-positive pili are formed from a single chain of covalently linked subunit proteins (pilins), usually comprising an adhesin at the distal tip, a major pilin that forms the polymer shaft and a minor pilin that mediates cell wall anchoring at the base.
Statistics
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PSSM-Id: 318704
View PSSM: pfam16555
Aligned: 3 rows
Threshold Bit Score: 192.317
Threshold Setting Gi: 495018186
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81744355   19 TSLLSVAPAFADEATTNTVTLHKILQTESNLNksnfpgttglNGKDYKGGAISDLagyfgeGSKEIEGAFFALALKEDks 98
gi 495018186  21 SSFVASTQAFAADTSTVNVTLHKRVFDEGQLP----------ADKQNTGEVTTDF------GGMPLAGVTFTAYDVTD-- 82
gi 765411222  28 VH--------AEDTASTTVIVHKIVMNNDDFNkft----yeeNLSKYNGNSIGDLknyfgnSAVEVAGVKFDVWKKTDvv 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81744355   99 gkvqyvkakEGNKL-----TPALINK----DGTPEITVNIDEAVSGLTPEGDTGLVFNTKGLK-----GEFKIVEVKSKS 164
gi 495018186  83 ---------QYLTLrgsgdTAQQAIAqiqaDSTNSAPAYATMLSSGVTTAPDGTYTFTNLALKdgnkdKVYLFLETDSPT 153
gi 765411222  96 ap----eakTGAELgitgdTNKYVKT----DKT------------AMTQDNGATFTLAN---------GIYIFTEDKENS 146
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 81744355  165 TynnngsllAASKAVPVNITLPlVNEDG-----VVADAHVYPKNTEEKP 208
gi 495018186 154 N--------VIAKAAPIVLAMP-IYANGsd-tqINTNIHVYPKNEKADP 192
gi 765411222 147 PyynnqnelTGMKAVPFKLELPqAKTDGsgyfdTKTPLHVYPKNTENKP 195
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