2YMB


Conserved Protein Domain Family
MIT_C

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pfam16565: MIT_C 
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Phospholipase D-like domain at C-terminus of MIT
MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.
Statistics
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PSSM-Id: 318714
View PSSM: pfam16565
Aligned: 64 rows
Threshold Bit Score: 161.898
Threshold Setting Gi: 0
Created: 1-Aug-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YMB_A        108 GFSYESLFREYLNEtVTEVWIEDPYIRHTHQLYNFLRFCEMLIKR---PCKVKTIHLLTSLDE----GiEqVQQSRGLQE 180
39_pfamImport   1 GISYENLFGDYLAG-ANSITLIDPYIRLPYQLRNFMEFAKLLSEKk-nKENELRLHLITNNNE----D-FiEGAREAFSQ 73
12_pfamImport   1 GVSFDTLLVPYLRG-AGKITITDPYIRQFHQARNLMELIEGIANVk-dPADEVHIKLVTAENRdgdgD-KlRKQLEYLVK 77
29_pfamImport   1 GISYETLLMPYLLG-ASEISIVDPYIRLAHQGRNLVDLLALLAASk-dPADEIAVTLVTKEVRg---E-YeQQHLLMLKD 74
49_pfamImport   1 GVSYESLLLPYLRG-ATDIRIVDPYIRLPHQGRNLVDLLALVASVk-dPADEIVVKLVTKEDKg---D-FqQQHLLMLKD 74
42_pfamImport   1 GVTYDKLFDQYLQG-ARKITVTDSYIRIFYQIRNFMEFLETIAKIk-pKDDEVKVHLITAEDE----F-KgPQQVENFMK 73
gi 81566517   535 GLSFDTLLGPYLKG-ATTITVTDPYIRLFYQVRNFMEFLETVVKHk-aPDEEVSVHLVTTEDE----F-KgEQQKDNFEK 607
2_pfamImport    1 GISFDGLFGAYLKG-ASKITVTDPYIRLFYQIRNFMEFLEAIVKNk-aEEDEVAVHLVTVRDE----F-KgDLQDESFEK 73
gi 122543078  543 GISYNKLFAPYLEG-ASRIVVTDPYIRYFYQIKNMMEFVEMVIQRk-aLEDQVAVHLVTGPDD----G-NvQKQRELLDS 615
14_pfamImport   1 GVSYEKLFGPYLEG-ARSIEIIDPYIRTFHQCRNLMEVLEVIITHfdyCVPEIHVHLLTCPDQ----Y-DpVKQDDYLCQ 74
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2YMB_A        181 IEESLRSHGVLLEVQY--SSSIHDREIRFNNGWMIKIGRGLDYFKK--PQSRFSLGYCDFDLRPCHETTVDIFH 250
39_pfamImport  74 ITYSLETIGIIFTYEF--DENIHDRSIKIDNGWKIVLGRGLDIWQK--TGGWYDINEYIQEKRLCKACEVTFIY 143
12_pfamImport  78 IKQGALAGGIHFDVAF--DGAIHDRSIVTDTGWKILLGRGLDIFQYv-TGDVFDLATKLQEYRQVKAFGVTYIR 148
29_pfamImport  75 IQDSAATVGIQFTVAW--DQTIHDRSIRTDHGWKLLLGRGLDIFQKg-SGNQFDLGSRRQEFRQVFAFGITYIN 145
49_pfamImport  75 IQDGGASVGIKFNVEW--DETIHDRSITTDNGWKILLGRGLDIFQKg-SGSQFDMGARRQEFRQVVAFGVTYIN 145
42_pfamImport  74 IQENCAIAGVRFSWEFdeNQILHARHIVTDHGWKILLDRGLDIFQHyeMNDSFSLSNRLQQYRSCKAFEITYLR 147
gi 81566517   608 MKEAACSVGVNFTWEFdgTGTIHARHIVTDHGWKISLDRGLDIFQHyeMNDAFTFANRLQQCRPCKAFEVTFIK 681
2_pfamImport   74 IQESARTVGIDFTWEFddSGTIHARHIVTDHGWKISLDRGLDIFQHyeMNEAFAFANRLQQFRSSKAFEVTFIR 147
gi 122543078  616 ITEACTGTGVDFTWAFdsSGTGHSRDIITDTGWKIVLDRGLDIFQApmRRDGFTLGDRLQEHRMLKNFYVTYVR 689
14_pfamImport  75 IADALHPFGLTLEWDFddTNTIHARHFVIDDKWDILLDRGLDIWQKfdSGNAFAIESRVQEMRMVKQFEITYMK 148
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