3QHE


Conserved Protein Domain Family
Sam68-YY

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pfam16568: Sam68-YY 
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Tyrosine-rich domain of Sam68
Sam68-YY is a short tyrosine-rich domain on Src-associated in mitosis, 68 kDa protein (Sam68), a protein that regulates TCF-1 alternative splicing. It is a crucial binding-partner of the APC-Arm domain that forms a superhelix with a positively charged groove, the surface-residues of which groove form numerous interactions with Sam68-YY to fix it in a bent conformation. APC-Arm is the armadillo repeat domain of the tumor-suppressor protein adenomatous polyposis coli or APC. APC plays plays important roles in Wnt signalling and other cellular processes.
Statistics
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PSSM-Id: 318716
View PSSM: pfam16568
Aligned: 28 rows
Threshold Bit Score: 48.9835
Threshold Setting Gi: 355333017
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
3QHE_B         2 YEEYgydd----tyaeQSYEGYE-GYYSQSQGDSEYYDYGHGEVQDSYEAYGQDD 51
gi 351715547 120 YGEYdyvdrygtahdeQSYNSYDnSYLTPAQSGTDYYDYGHGLSEETYDSYGQEE 174
gi 944363382 122 YGEYeyddgygtaydeQSYDSYDnSYSTQAQSGADYYDYGHGLSEETYDSYGQEE 176
gi 410911306 261 YGEYeyddgygtaydeqXYESYDnSYNNQGQNSDDYYEYGH--SGESYDSYGVEE 313
gi 808868622 239 ygeyeyddgygtayddQGYESYDnNYSNQGQNSDDYYEYGH--SGESYDSYGLEE 291
gi 973189931 274 YDDYgyddgydgeydnQTYDVYDdSYSSQTQSIPEYYEYGHGTGDDAYDSYAEED 328
gi 542150142 235 YEDYgyddgyggeyddPSYEAYDnSYATQTQSVPEYYDYGHGTSEEAYDSYAQEE 289
gi 741970123 267 YEAYgydgyg-geyddEIYETYDnSYPIQAQSVPEYYDYGHGVSEDAYDSYAPEE 320
gi 351713907 237 YEEYgydeghgghyeeQSYEAYDsSYATQAQSVPEYYEYSHGVSEDAYDSYAPEE 291
gi 348588631 285 YEEYgyddgygeeyeeQTYQAYDhSYAPQTQSVPEYYEYGHGVNEDAYDSYATEE 339
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