Conserved Protein Domain Family
GramPos_pilinBB

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pfam16569: GramPos_pilinBB 
Gram-positive pilin backbone subunit 2, Cna-B-like domain
GramPos_pilinBB is one of the major backbone units of Gram-positive pili, such as those from S.pneumoniae. There are three major pilin subunits that form the polymeric backbone of the pilin from S. pneumoniae, constructed of three transthyretin-like, CnaB, domains along with a crucial N-terminal domain, D1. The three Cna-B like domains are stabilized by internal Lys-Asn isopeptdie bonds, Gram-positive pili are formed from a single chain of covalently linked subunit proteins (pilins), usually comprising an adhesin at the distal tip, a major pilin that forms the polymer shaft and a minor pilin that mediates cell wall anchoring at the base.
Statistics
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PSSM-Id: 318717
View PSSM: pfam16569
Aligned: 11 rows
Threshold Bit Score: 106.289
Threshold Setting Gi: 225038182
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81768238  198 IGDVVKYEVKASIPvyqKN-AQNIMY--K--F--T--DTMSKGLTY--D-EK-TGFKVTSGDk-vFAK-DTD-Y-TVDV- 259
gi 81744355  250 IGKVVPYEVKTKIH---KG-SKYENL--V--W--T--DIMSNGLTM--G-ST-VSLKASGTTe-tFAK-DTD-Y-ELSI- 308
gi 123112409 365 aggadgitVNGVKS---ET-SPYSVF--K--W--G--DTAEQGLSY--VaAK-ANIKVTNKDgsvVLKeNTD-Y-KIQN- 426
gi 336013937 141 IDEVIPYKLTGTLPs--NY-AEYETY--FyeF--N--DIMSAGLTF--DkMS-VKVTVDGTT---LTA-DQD-Y-SLIV- 201
gi 503143947 211 IGDTVNYTITGKVP---NT-TGFGDY--T--YkiF--DTFSEGLSF--N-ND-LKVSVGGID---VTA-TT----VVTT- 267
gi 524440885 199 IGDSVNYKITSRVP---NM-KGYTKY--F--F--VmeDTLSKGLTY--N-ED-MVITIGAKT---LVK-DTD-Y-PLTV- 257
gi 505370572 194 IGDKVPFVIASKVP---QM-QGYTKY--F--FvlN--DSMTAGLTY--N-KD-VAIKIGTTT---LAA-D-A-Y-DVTY- 251
gi 502253224 202 IGDDVPFQLTATLA---NNiESYKAYslE--F--D--DTLSKGLDY--N-ND-AVIKLGEKD---V----TD-YfTPSY- 259
gi 524007927 187 VGETVNYTITGKVP---DT-MGFETY--T--YeiA--DTMSEGLTF--NrNS-LAVKVGSAD---VTA-DTDkC-TIAY- 247
gi 524471070 188 IGDNVPFQLTGTVDa--KY-DKYGSYyyA--F--H--DTMSDGLTF--N-ADsVTVTVDGTA---V---TTG-Y-EVVT- 246
gi 225038182 230 VGDEVTFRLKAIVPdypED-ATYRKF--V--V--S--DKLGTGFDYsgD-ET-IKVFRDEAGq-qVIG-NEN-Y-TIAEt 294
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81768238  260 --KK--QEDGSTVITINFVY-ENIKAYAETGITLNYQATLNKDA-VI-S-N--KenlgNTNNIQLDYTNNP 320
gi 81744355  309 --DA--RGFTLKFTADGLGKlEKAAKTADIEFTLTYSATVNGQA-II-D-N--P----ESNDIKLSYGNKP 366
gi 123112409 427 --SE--NGFVIDFIVNNGQVsDTVASLHGQDLQMTYNMYVNDSA-AV-A-N--P----LTNSVDFVYNNNP 484
gi 336013937 202 --HS--DTNSFQVRFENLKAiQSVMITSTSQIVVEYKCRLNGNA-VI-AgN--G----NPNTAYLVYSNNP 260
gi 503143947 268 --PD--APHTFTVAVPMVNGtGAAIYTIGEEVIITYTATVNENA-AIgE-S--G----NNNDAKLVYSNDP 326
gi 524440885 258 --TK--NADGTTSLEIVFKNfIQYKGQTDAAITLTYSATLNQDA-VL-D-PttG----NPNTVKLIYSNNP 317
gi 505370572 252 --DD--TANTMKIVIKDFI---QYKSEAGKDIVVTYSATLNEKAdLT-Q-A--G----NKNTVKLTYSNNP 307
gi 502253224 260 --DA--TAKTLTFTCDNILAfG---AKNSDQIVVEYTAKLNENA-VIgA-A--G----NPNKVSLKFSNNP 315
gi 524007927 248 --DA--ETAPNTFKVTILVKnCTV----GDAITVTYTATVNEKA--I-A-V--V----SKNEAKLTYSNdp 300
gi 524471070 247 --EDldDGCTFEVRFADLKNiKAVK--AGSKVVVNYTAKLNENA-VIgE-G--G----NTNVSKLEYSNNP 305
gi 225038182 295 peKE--RTFQINFEDAFIT------ENAGQTIYITYRAVVNDEA-FT-V-D--E----LKNDAFLGYNNDP 348
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