3OOC


Conserved Protein Domain Family
HlyD_D4

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pfam16572: HlyD_D4 
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Long alpha hairpin domain of cation efflux system protein, CusB
HlyD_D4 is the long alpha-hairpin domain in the centre of CusB or HlyD proteins. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons. HlyD_D4 is thought to interact with the alpha-helical tunnels of the corresponding outer-membrane channels, ie the periplasmic domain of CusC.
Statistics
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PSSM-Id: 318720
View PSSM: pfam16572
Aligned: 5 rows
Threshold Bit Score: 67.9913
Threshold Setting Gi: 896400917
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
3OOC_A       150 LLDLTIPDWVEAQSEYLLLRET--GGtATQTEGILERLRLAGMPEADIRRLIATQK 203
gi 123759091 161 IAELLVPEWAAVQQEYLALKAL--GD-PSLEGAARERMRLSGMPESLIRDVAARGK 213
gi 512681863 265 LAQLTIPSWVEMQSEYLVLVEL--KRsRAELDAVLLRLKLAGMPDADIEALRRTKK 318
gi 500122175 192 LLDLYVPEWVAAQEEFLAVKRMqgSDlASLVDGARQRMRLAGMSDEQIRQVEASGK 247
gi 896400917 127 LADLLIPEWAAAQEEYLALRRA--GD-AALLDAARQRLRLAGMPASTISRLERSGK 179
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