Conserved Protein Domain Family
RGS12_usC

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pfam16612: RGS12_usC 
C-terminal unstructured region of RGS12
RGS12_usC is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies at the very C-terminus. It has a highly conserved central section. The function is not known.
Statistics
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PSSM-Id: 318753
View PSSM: pfam16612
Aligned: 12 rows
Threshold Bit Score: 113.09
Threshold Setting Gi: 859899378
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620983923   576 TAQPN-----GKADAAQSCGENSLKNAg--------------pSE--G--R--PRPGPAALHASRQKPSALPFVAPLSpi 630
gi 532066404  1245 AVQPS-----GSWEPAQDCSDSPATSPgsaqs------pssthSP--GstH--SPPGVPGTTAPGQNTPGEPFCAPQG-- 1307
gi 847095818  1254 AAPSSramngTRQETPPKCTDRPLKSG--------------------G--L--DRRDKPDFLQAGSRKPYVPFNAPLSpi 1309
gi 557027358   400 TQQPG----------KLDYNENSSNKTrp-------------pDPleN--R--YRCASVPLNSHKSDSCNVPFSAPLSpi 452
gi 733886977   326 CTSPS-----GKQEPIQNYNENSVKKM----------------AH--S--EnkHKAALTAL--HSQKSFSVPFNTTLSpi 378
gi 1020979471  596 CTSPS-----GKQEPVQNFNENSVKKM----------------GY--S--EskHKSALAAL--HSQKTFSVPFSPPLSpi 648
gi 821491271  1249 AAQPN-----GKLESPPSGPESPAKSP----------------GP--A--EskPRPPLAAL--PTQKSYSGPFSAPLSpi 1301
gi 731486872  1221 ALPPG-----ERWE-AQDRGESSAASPss------------asSQ----------PRSPAATSPGQKPPAGPLPSPWAph 1272
gi 1034049560  453 ASQPG-----ERWEPVQDSSDSPSTSPgs------------asSP----------PGPPGTTPPGQKSPSGPFCTPQSpv 505
gi 254553475   595 AAQTE-----------ESYSDSPATSPasaqspcsayspgsahSP--G--SahSTPGPPGTTQPGEK-PTKP-----Scv 653
gi 859899378   449 APWPS----------ATSPTTSPATSPatspttspttspssagSP--------------------------PFSAPQTps 492
gi 562848367   622 ATQPG-----DRQEPAHDYSDSPVSSPatst--------gsahSP----------SGPPGTTPPGQNSPSGPFCAPLPpt 678
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620983923   631 phaQEGPSQVWRRQSRELPPEGIQTIDDDNVADLTLVGEGDINSPNSTLL-P-----------------PPPSPpada-- 690
gi 532066404  1308 ---QEGSTQIWRRQSRDVEAGDIQTVEDEHVADLTLMGEGDISSPNSTLL-P-----------------PSPSP------ 1360
gi 847095818  1310 phvQERNKPGKERHSRDLPLDNIQTIEDENVADLTLVAEGDISSPNSTLL-PpppsppcdlsklseanfSPPPSfm---- 1384
gi 557027358   453 phvQDTSLPRWDRKSGDWQTETIQTVDDENVADLTLVAEGDIASPNSTLL-P-----------------PSPTPpssv-- 512
gi 733886977   379 phaHENSAAIWKRQSRELQAEGIQMIDDENVADLTLVAEGDISSPNSTLLpP-----------------PPPPQpsevsk 441
gi 1020979471  649 phaQENNATVWKRQSRELQAEGIQMVDDENVADLTLVAEGDISSPNSTLLpP-----------------PPPTPpsdi-- 709
gi 821491271  1302 prvQE--AQIWKRQSEELPGEGIQTIDDDNVADLTLVGEGDISSPNSTLL-P-----------------PPPTPpsda-- 1359
gi 731486872  1273 paaQEGASKTWRRQPREVE--GVQTLEEDPTADLTLVGEGDISSPNSSLL-P-----------------PLPTPpasahh 1332
gi 1034049560  506 slaQEGTAQIWKRQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLL-P-----------------PPSTP------ 561
gi 254553475   654 smvQEGTTQAWRRLSPEMEAGGIQTVEDEQVADLTLMGEGDISSPNSTLL-P-----------------PPPTP------ 709
gi 859899378   493 phsQEA------------EAGGVQTMEGEHVADLTLTGEGDISSPNSTLL-P-----------------PTPTP------ 536
gi 562848367   679 phmQEGATQIWKRQSREVEAGGIQTVEEEHVADLTLIGEGDISSPNSTLL-P-----------------PPSSP------ 734
                          170       180
                   ....*....|....*....|.
gi 620983923   691 -----dklaQANYSPPTPLTD 706
gi 532066404  1361 ---------QDTPGPPRPGTS 1372
gi 847095818  1385 -------gsQDNSGYQRSGIS 1398
gi 557027358   513 -----sklmEANFSPPTPLTS 528
gi 733886977   442 lteanyppptpfagnqeksgy 462
gi 1020979471  710 -----skltEANYPPPTPFag 725
gi 821491271  1360 -----tkltEANYTPPTPLTD 1375
gi 731486872  1333 apptplldtQDTPGLQRPGgg 1353
gi 1034049560  562 ---------QDVPGPSRPGTs 573
gi 254553475   710 ---------QDTPGPPRPGTS 721
gi 859899378   537 ---------RDSAGPPRPGGG 548
gi 562848367   735 ---------QDTPGPPKPGGG 746
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