Conserved Protein Domain Family
INTAP

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pfam16617: INTAP 
Intersectin and clathrin adaptor AP2 binding region
INTAP is a natively unstructured region of intersectin 1 proteins, lying between the first pair of SH3 domains, that binds to the clathrin adaptor AP2. This binding forms an intersectin-AP2 complex that functions as an important regulator of clathrin-mediated SV recycling in synapses.
Statistics
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PSSM-Id: 318758
View PSSM: pfam16617
Aligned: 10 rows
Threshold Bit Score: 93.0017
Threshold Setting Gi: 821034806
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597775406  827 KIPESEVPLNLRASAT--S--GSAPKLVSRITPTSssttptalqtaptetvPVAPpttatv--ppgpaSS------SSSA 894
gi 512823981  736 RMPEGEFPSTTKQAAD--T--TAKPTVHLAPSTPT----------------PAAF-------------TD------NSAN 776
gi 637283728  796 KISESEITNSVKPITD--V--TVPPKVSLRETPTT----------------PLAPpl----------pTD------SSTT 839
gi 973191246  610 KIPESDVPASLKPGAG--S----APKVAARVTPTS----------------AVSAgsqpppaetpaapPT------TTAA 661
gi 961906572  851 RIPESEAPISLRPPS---S--ATPPSTQQ----------------------PMATpp----------sASghastsTSSA 893
gi 821034806  803 KIPENEVPAPVKPVTD--StsAPAPKLALRETPA-----------------PLAVt-----------sSE------PSTT 846
gi 700348186  265 KIPENEVPASVKPAVE--A--AAAPKVSVHETT-T----------------SLGTpa----------sTE------CTTT 307
gi 1438933    174 KIPENEVPAPVKPVTDstS--APAPKLALRETP-A----------------PLAVt-----------sSE------PSTT 217
gi 620974640 1042 RIPESEVPAPSKPAAD--P--PPAP-AALRETP-T----------------PVApa-----------sSD------SSTA 1082
gi 46395470   760 KIPESEVPLSLRASAA--S--SSAPKLGSHMSSASssttatpilpvstepaSIAPpssapp--ptgpaSS------SSSA 827
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597775406  895 SSNWADFSTTWPTNSSvEKQDSDGWEAWPTqptqpaqppQPSLSVPSGGQGRQRSAFTPATL-SGSSPSPVLGQGEKVEG 973
gi 512823981  777 SNNWADFSSTWPTNNT-DKAETDNWDTWGA---------QPSLTVPSAGQHRQRSAFTPATV-TGSSPSPVLGQGEKVEG 845
gi 637283728  840 ANNWADFSSTWPTNAT-DKQETDNWDAWAA---------QPSLTVPSTGQLRQRSAFTPATV-TGSSPSPVLGQGEKVEG 908
gi 973191246  662 GSNWADFSSTWPSNNS-EKTEGDGWDAWPT---------QPSLTVPSTGQLRQRSAFTPATI-TGSSPSPVLGQGEKVEG 730
gi 961906572  894 NSNWADFSTTWPSSTA-SQSDSEGWDAWPTssa----nqNPSLSVPSA-QLRQRSAFTPATMtTGSSPSPVLGQGEKVEG 967
gi 821034806  847 PNNWADFSSTYVlgekveglqaqalypwrakkdnhlnfnkndvitvleqqdmwwfgevqgqkgwfpksyvklisgpirks 926
gi 700348186  308 ANNWADFSSTWPTNTS-EKPETDNWDAWAA---------QPSLTVPSAGQLRQRSAFTPATV-TGSSPSPVLGQGEKVEG 376
gi 1438933    218 PNNWADFSSTWPTSTN-EKPETDNWDAWAA---------QPSLTVPSAGQLRQRSAFTPATA-TGSSPSPVLGQGEKVEG 286
gi 620974640 1083 SNNWADFSSTWPSNTN-EKAETDHWDAWAA---------QPSLTVPNTGQLRQRSAFTPATV-TGSSPSPVLGQGEKVEG 1151
gi 46395470   828 SSNWADFSTTWPSNSAvEKQDSDGWDAWPTqp------tQPSLSVPSGGQIRQRSAFTPATL-SGSSPSPVLGQGEKVEG 900

                  ..
gi 597775406  974 LQ 975
gi 512823981  846 LQ 847
gi 637283728  909 LQ 910
gi 973191246  731 LQ 732
gi 961906572  968 LQ 969
gi 821034806  927 ts 928
gi 700348186  377 LQ 378
gi 1438933    287 LQ 288
gi 620974640 1152 LQ 1153
gi 46395470   901 LQ 902
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