3SC0


Conserved Protein Domain Family
MMACHC

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pfam16690: MMACHC 
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Methylmalonic aciduria and homocystinuria type C family
Statistics
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PSSM-Id: 318822
View PSSM: pfam16690
Aligned: 27 rows
Threshold Bit Score: 198.628
Threshold Setting Gi: 802672603
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3SC0_A        23 GFEVYPFQVAWYNELL--PPAFHLPLPGPTLAFLVLSTPAMFDRALKPFL-----------------QS-CHL------- 75
gi 75012988   24 GFESHMFKIGSYNEAVgeSSPFALPYDDSTMALLILSTPDMFDVAFRKWV-----------------VQkTMD------- 79
gi 405950162  13 dLEFNPRLIGWYNEHV--QEVFRLSYPADTLGLLVISTPDMFERAFIPFVk----------------EQ-EEC------- 66
gi 761912578  24 GLEAHPFKIQWYNDKV--SDSFKLPYNGDTLAVLIISAPKMFEELLKPFIlggkykregfnalkdeeNE-RKE------- 93
gi 675848126  20 GLEAYPFKIGWYNDEV--HKSFHLEYDYDTLAFSLVSLPKMFDILFCPFL-----------------EQ-WDG------- 72
gi 196011110  20 GFECAPFKISWYNDQV--DDHFKLKCNQNALAFIIISLPQMFDKTFKTFI-----------------MK-KYNidnfple 79
gi 541039356  20 GFECHRFKVGSYNALV--ASEFQLAYEADVMAVVVLNTPSFLETTFKHWL-----------------QSqKGE------- 73
gi 541049028  76 GFEWYRFKVGSHNAIV--QENVRLKFEDDVLGVLVLNTPSFFETTFKEWL-----------------RQhCNP------- 129
gi 802672603     --------------------------------------------------------------------------------
gi 156379309   1 ------FQIGWYNNQVt-HKQFQFPFDPDTLAFVIISTPEMFEKGFKPFI-----------------TD-ADC------- 48
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3SC0_A        76 ----------------RML---------TDPVDQCVAYHLGRVRESLPELQ--IEIIADYEVHPNRRPKILAQTAAHVAG 128
gi 75012988   80 ----------------FGSfdev-cemvSSPIQSFLEDRLEIMSEKLRKVEenFEILHDYSMTPQRRPKILMQTCGHVAG 142
gi 405950162  67 ----------------DGI---------RDPIDQCVAYYFNKVKEDFPEYE--VESIHDYEMHHSRRPKILVQTVGHVSG 119
gi 761912578  94 ----------------EGG---------SDPLDQCFRDVFNKLQTHFSQYK--TTFIQDYELHHNRRPKILLQTAGHVSG 146
gi 675848126  73 ----------------KGG---------NDALDECMRFYLNKLKSNF--TD--VELIHDFEFHHSKRPKVLVQTAGHVSG 123
gi 196011110  80 dkaewneeekeefsynQNV---------YDPLDQCMLDYFQKIRNHFPDHQ--LHIIRDFEMDASHRPKVLVQTAGHVAG 148
gi 541039356  74 ----------------HEAlneliakfgANPLQAYFIRKFGQVIKDLRPVE--ARVIHDFDFNNNCTPKVLLTTCGMVSG 135
gi 541049028 130 ----------------GEGvddvktkvgPHPVETFFNWKFMQIEMHLSPIR--VVSICDFEPVRHRLPAVSLPACGHVSG 191
gi 802672603   1 -------------------------------------------------------------mndnliiKILMCTCGHVAG 19
gi 156379309  49 ----------------LGS---------RDPIDECMAAFFLKVKQAFPCHE--IDAIHDFELHPNRRPKVLVQTAAHAAG 101
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3SC0_A       129 AAYYYqrq-dvEADPW-GNQ------------RISGVCIHPRFGGWFAIRGVVLLPGIEVP--D-LPPRKPHDCVPTRAD 191
gi 75012988  143 AAFYYq-----PCHFQeDGVtwppagrmgpnlKFIGLSLHPIYGGHFAFRSVLIFPNVKIP--E-FCEKEPRPILTASED 214
gi 405950162 120 AVYYYqks-dvTDQPWpTDK------------KICGVCYHPVYGGWFGLRGVLIFKDVLCP--P-LQQPLPKDVIPSQEK 183
gi 761912578 147 SAYYYqrg-dvPRAPWgEDK------------PIYGVSVHPRYGGWFAFRGVLIFEDIRVKgeE-LEYKDPIDCVSKREK 212
gi 675848126 124 GVFYFqrkdikHSDPWpENR------------KICGVCLHPKYGGWFGLRGILIFKNVKVP--N-LMKKE-LECFLSNEQ 187
gi 196011110 149 AVRYYqrc-dvHDDPWdESQ------------RIYGTCVHPKYGGWFALRGVIIFEDVNAN--K-LAQVDPPDMIKTDQD 212
gi 541039356 136 AAYFYr--------PLeSGKsridpv-thvekRSMGLSLHPKFGGHFGFRAVFIFPRVHLP--AdFKEKTAPMRLDTPEK 204
gi 541049028 192 AAYFYh-----PNHPVtGEKiy-----------pqGLSLHPKYGGYFAFRGVIIFPDVHLA--AtFKEPQPLKTLDTDAK 253
gi 802672603  20 AAYYYrqs-dpTLSETkDGKkwdpkp-aaanlKFIGLSLHSDFGGHFAFRSVLIFPHISLP--SsFKEREPVAVLHTIDE 95
gi 156379309 102 AAYFYqrk-diTDDPWpPTQ------------RICGVCVHPKYGGWFAIRGVLIFKTFKYP--D-LPRKQPMDVVVGDEK 165
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
3SC0_A       192 RIALLEGFNFHWRDWTYRDA---VT-PQERYSEEQKAYFSTPPAQRLALL 237
gi 75012988  215 VRTALEKFNYNWKDSGFRDF---GN-PTRRYSTTQMEFFGRPVAERWEVL 260
gi 405950162 184 RVELLNKFNFHWQDWTFRDL---LP-VRQRYSQEQIMYFSTKPKDRPELI 229
gi 761912578 213 RIELLEEFNYHWEEWRYRDIldgGD-VEDRYSEEQKEYFGTLPKDRHKLV 261
gi 675848126 188 IISLLDKFNNSWRDGTFRDV---IE-PLERYSTLQQKYFNVTPDERLELI 233
gi 196011110 213 RIRLLNLYNFHWRDWSFRDV---LPgVVARYSDEQKTFFSTPPSQRPQIL 259
gi 541039356 205 QKEALDLFNNSWKDGRFRDC---GD-PLERYSELQLKYFSTPPMARWQLI 250
gi 541049028 254 VLEALELFNKHWMDNRYRDC---GD-PIEKYSALQLKYFNTVSRRRWRLI 299
gi 802672603  96 IKDALEKFNYAWKDSRFRDC---GN-PKERYSSTQMEYFGKPPSERWEVI 141
gi 156379309 166 RIELLEKFNFHWEDWSFRDV---VP-SERKYSDQQIKYFSTLPVNRKDLL 211
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