3V42


Conserved Protein Domain Family
Folliculin_C

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pfam16692: Folliculin_C 
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Folliculin C-terminal domain
This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity.
Statistics
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PSSM-Id: 318824
View PSSM: pfam16692
Aligned: 14 rows
Threshold Bit Score: 213.38
Threshold Setting Gi: 402591034
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V42_A         9 LRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVDLVQSA-FEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLG-------L 80
gi 699248616 335 LRHMREVLQPPLFKAIAWHLVVGNQVIWKGQDQDLITSA-LVVLKQLLPVGCVKMQTRSDKYLNSYKANLLG-------L 406
gi 780113861 512 yasnwQVLGSLNFHDVAYNVLIGNQLIARADCKSTLKSL-FKVLKVILPAGCCRIISHSPTYQASWKCNFLG-------L 583
gi 66813290  446 LSQVNRIMGEDAFSILVYNIIIGNQVIIRGQNERLVTSM-VSVVKEILPKECVNVCNFSNTFKELWECNILG-------L 517
gi 470246390 385 LGQVCKIVGEASVSALIYNVVVGNQVLVRGQNAALVGSL-INCLVDLAPSECMTVCMYSETFKEIWECNIVG-------L 456
gi 340377759 309 LRHFVSILGSEDFPELAYHIMRGDQLIVRGNDPSTVMSV-LNILKELVPESICRIIGFSSTYQESFVAEFLG-------L 380
gi 514695327 683 LSDLCNVLGTDSMRLALHHISIGNQCIVLASQPSVSTAI-AQLLACTLPDRCVSLNVNQREYVPTYACNILG-------M 754
gi 350646522 577 LSRLFTVLGINPFSRLVQHIAVGNQLVVQSLTEDIHSTLtLSALAKLLPKGCIRQVIGSHEYLAPFRCNLLSvtnnlimL 656
gi 410928554 330 LRHLRQVLGAAEFRQLVWHVLMGNQVIWRGAEPSLIQSA-FIVLKSLLPVGCVRSIpFSAQYEEAYKCNFLG-------L 401
gi 94536631  329 LRHLRQVLGTADFRQLTWHVLMGNQVIWRGADPGLIQSA-FNVLKALLPVGCVRAVqYSPHYEEAYRCNFLG-------L 400
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V42_A        81 SPHVQIPPH-VLSSEFAVIVEVHAaa--rsTLHPVGAEDD--------QSLSKYEFV-VTSGspva-adrVGPTI---LN 144
gi 699248616 407 TEKACVPSH-VKSAEHFILIHVLRknn-ngQKFSHIYPSLpp----nnNSMNGIEFR-VTNScil---peKGPEM---LN 473
gi 780113861 584 STGTELPEH-LITSEVYLLLDVISpvn-lkQDSNRVVSRTa-------GPFKGHGIS-ITSSsvv---pdKVPTI---LS 647
gi 66813290  518 NTSAVIPLH-I-DKDICCIVDIDYydl-skEPDDIDHPN-----------RSTIEIT-CSGS--------KFPST---LG 571
gi 470246390 457 APNVVIPRH--VDRTVIAIVDIDYyds-skEPEDIDHPD-----------RSTIEIS-FSGP--------KYTSS---MG 510
gi 340377759 381 SVGVNLPRH-IVDSELHVLLDILPplkryySKSAGDQPNSvlggadivEPLEKYKLM-VYSAqpcl-hdqKYPVI---IR 454
gi 514695327 755 SGAGSLPDD--LASKGAVLLRIHTave-amTDGADGADAD-----------VDEDWP-FYAPikrv-dveGSPGPdghVN 818
gi 350646522 657 EEDVNMAKD-VL----------YLaln-fkLCSTI--PSF--------DS-ELILFK-QSLPcrhistsnNHPSI---TT 709
gi 410928554 402 SPDVPIPTHvSSSEFSVLVD-VSSe-----A-----SCQnsavan--ddvstLHQFTiSSANtqp---adrGPTL---LN 462
gi 94536631  401 SPDVPIPAHvSSSEFSVLVDVLSAe-----R-----GCVnpvsd---ddilsLYQFH-ISSAntqp--tdkGPTL---LN 461
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V42_A       145 KIEAALTNQN---------------------LSVDVVDQALVALKEEWMNKVKVLFKFTKVd---sRP----KEDTQKLL 196
gi 699248616 474 KVEVAIANDS---------------------LSPEVVRHCLICLKEEWMNKVKILYKFTKId---nRD----KEETARML 525
gi 780113861 648 RIVTTLNNSD---------------------LTPEIVVTVLTTLKEEWMNKVKLLFKFTRAg---sHT----DEDTEKLL 699
gi 66813290  572 IAIESIYKQY---------------------CTITLENIQLKSIKEEWINKSKSFYSIKTI-----IE----NEKDKRLF 621
gi 470246390 511 SAIEYVILQN---------------------YPPEVERIHLLNIKEEWINKTKAFYGVRSI-----IE----DVSDKRLQ 560
gi 340377759 455 RLMALLTGDG---------------------ISDQMVSRGILALKEEWMNKVKILYKFSQVy---pKDslenDEKLNKLV 510
gi 514695327 819 TFVTAVLEASer------------------pHDPELSVELLRALREKYTRIAKMYFALTR------GK----KVPPYRAL 870
gi 350646522 710 IARQLLSNSGgriaisnyvqqviklfninpaLPIDVCSIALSTIQHEWIHRARLLYSFKRCqgsslSG----EEATRRWT 785
gi 410928554 463 KLEVALSNEN---------------------LSVDVVSHCLLCLKEEWMNKVKVLFKFSKVd---gRG----REDTQKVL 514
gi 94536631  462 KLEVALSNEN---------------------LSVEVVSLCLLCLKEEWMNKVKVLFKFSKVd---gRG----KEDTQKVL 513
                        250       260       270
                 ....*....|....*....|....*....|.
3V42_A       197 SILGAS----EEDNVKLLKFWMTGLSKTYKS 223
gi 699248616 526 QGCLQC----TDDDVRLLKFWMTGLSSKFKE 552
gi 780113861 700 KILQA-----KVEDKPLLRFWITALSSQYRS 725
gi 66813290  622 SFLNIInchhFEKDMEILMFWSMCARKWFIQ 652
gi 470246390 561 KFMQIInc-vYEKDIMILMFWTTCVRKQFVY 590
gi 340377759 511 KEVLFV----TPEDMPILLHWRSALRKDYRA 537
gi 514695327 871 QVLGL-----PPQDQQLLMFWTSALSPTQRr 896
gi 350646522 786 NVLTSInc-qSAENAAVARFWQGALSQYSRN 815
gi 410928554 515 ALLGAtg-pgEEDNVRLLKFWMTGLSKTYKS 544
gi 94536631  514 ALLGAtg-pgEEDNVRLLKFWMTGLSKLYKS 543
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