2RRF


Conserved Protein Domain Family
ZFYVE21_C

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pfam16696: ZFYVE21_C 
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Zinc finger FYVE domain-containing protein 21 C-terminus
This is the C-terminal domain of Zinc finger FYVE domain-containing protein 21. It has a PH-like fold and is required for the regulation of focal adhesions and in cell migration.
Statistics
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PSSM-Id: 318827
View PSSM: pfam16696
Aligned: 18 rows
Threshold Bit Score: 123.966
Threshold Setting Gi: 121961779
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2RRF_A         9 EFYDKQLKVLLSGATFLVTFGNSEKPE----Tm---TCRLSNNQRYLFL----DGDSHYE--------IEIVHISTVQ-I 68
gi 121961779 104 EFYEKSIPALTQGTLMSVSEPIANSSE----SfgefDCKLSKDHRILKLvhtkKSKADANpp-----kIILSKLLEIKfI 174
gi 765158569 103 DFFDKQLKVLIAGGTFSVTPGESEKSE----Vm---TCRLTSHHLFLLL----DGETPLE--------VPVSRISSMQ-I 162
gi 390348112 103 EFFNKHLKALMNGCNFSVETLEEGQTN----S----YCKLTSNHRNILFndekPDKDNSKttmwvhdpVALLSIQNLQ-M 173
gi 340374467 100 EFYKHHLKILENGAYFELSDADG--------Ih---NCKLSSDHFQIIVt--gGSGSHPS--------LLMSSIMEIK-S 157
gi 675867826 100 iFFDEHLKYLQQGSVLNVMNYDVSDDNvkavPm---FCRLSRSQREILF------QCEKKqtvnviepILLSEIKEMI-K 169
gi 821455329  58 EFYDKQLKVLMNGATFSVTLGTSEESE----Lm---VCRLSNNQRYLFL----DGDSHYE--------IEIAQISTVQ-I 117
gi 410898822 104 EFYDKQLRVLLAGGTFGVTLGTTEKSE----Tm---TCRLSTNHRYLFL----DGESHFE--------VELSRISSMQ-I 163
gi 117558193 112 EFYDKQLKVLTAGGTFVVKVGSSEKSE----Tm---VCRLSNNHRYLFL----DGNSHFE--------VELSRISSMQ-V 171
gi 345311414  66 aastggarragQGATFFVTLGTSEKSE----Vm---VCRLSNNQRSLFL----DGDHHYE--------IEIAQISTVQ-I 125
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
2RRF_A        69 LTEGFPPGgGNARATGMFLQYTVPgtEGVTQl--KL--TVVEDvtvgrRQAVAWLVAMHKAAKLLY 130
gi 121961779 175 ITDSGDAG-TQKTPAGFKITYKDEedSAITH---SLilRAVEP-----KSSLPWLSSFQKAIKMLF 231
gi 765158569 163 LTDAASPG-ESSRPSGIVLHYKRMahMDTQQl--RM--DVTED-----KKGPAWLAAMYKAAKMMK 218
gi 390348112 174 MTSEANVN-GHVIPKAVTILYKYI--DEMREv--TM--TVPDDss--rKQSIAWIVALQKAYKLLN 230
gi 340374467 158 ITGHAPDGtPTNKLNGLKLTYRSDt-EDGEEidvTL--SPSPShs--rKQSIDWLKGLKKGLMIIH 218
gi 675867826 170 ISSHKHSN-----ITGIKLLYDNAs-REHQTc--TM--KVSPTsp-qqHHQLQWLDALLKAFELVQ 224
gi 821455329 118 LTEGFTPGgGNTRATGMLLQYKEPgaQDVTQm--KF--TASEDsnsnkKQSATWLAAMHKAAKLLY 179
gi 410898822 164 LADGTSPGgGTSRASGMILHYKPMgsQDGQQl--RL--EATEDk----KAASLWLAAMHKAAKLLY 221
gi 117558193 172 LTEGSTPGgGTLRASGMVLQYKPPgsLDLQQl--NM--DTADDk----RIASAWLAAMHKAAKLLY 229
gi 345311414 126 LTEGLTPGgGNSRASGMLLQYKAPgaEGMTQv--RF--TPHDDsnstkKLSATWLAAMYKAAKLLY 187
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