4EPF


Conserved Protein Domain Family
Pesticin

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pfam16754: Pesticin 
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Bacterial toxin homolog of phage lysozyme, C-term
This the C-terminal activator domain of pesticin, a hydrolase enzyme secreted by Yersinia pestis and other Gammaproteobacteria to kill related bacteria occupying the same ecological niche. It is referred to as a bacteriocin and it leads to the hydrolysis of peptidoglycan. Its immunity protein is Pim. Pesticin carries an elongated N-terminal translocation domain, an intermediate receptor binding domain, and a C-terminal activity domain with structural analogy to lysozyme homologs. The full-length protein is toxic to bacteria when taken up to the target site via the outer or the inner membrane. The receptor domain is necessary for the close contact with the outer membrane; the N-terminal is a type of translocational, TonB box; the C-terminal domain is the death-delivering domain.
Statistics
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PSSM-Id: 318872
View PSSM: pfam16754
Aligned: 7 rows
Threshold Bit Score: 226.13
Threshold Setting Gi: 392311798
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4EPF_A        170 IVDHDIFSSNgfEGFNp-TSHFPSNPSSdyfnSTGVTFGSGVDLGQRSKQDLLNDGVPQYIADRLDGYYXLRGKEAYDKV 248
gi 123658195    5 AIDFSFIAAL--EGAAitRGYVPDPDKS----KSGVTVGTGFDLGQRNVEDLQALNLPADLIRRLTPYLGLKGLKAKAFL 78
gi 122388091   88 DVDWDFIAEQ--EGRAvqDGYVPDATGS----KSGVTVGTGVDLGARDMNDLDRLGLSDALKTKLEPYLGKQGQDAADFL 161
gi 122374230    5 NIDFDFIHNL--EGFSl-KGYVPDPTIS----KSGVTVASGFDIGQCSKDEITS-HFPAELADKLLPYVGKTKQDALDCL 76
gi 290985537  252 KIDKGLLTKN--EAFSt-KGYVPQSKSGtvvgKSGVTVGTGFDIGQQNVKGLKSLGLSPSLVDKLSPYTGLKQQAAKNFL 328
gi 505037574  730 QIDIDFISNE--EGGQqtEGYIPDAPGN----MSGVTIGTGVDLGGLDIDELD---IPDNLKDKLRPYEGKQGEEAEEFL 800
gi 908641450  831 MINFDFIKEL--EGVKk-KGYVPDVENS----NSGVTIASGFDLGARSKSDLIALGLPASLVDKLTPYLGYKKSEAEAIL 903
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4EPF_A        249 RTAPLTLSDNEAHLLSNIYIDKFSHKIEGLFNDAn---------IGLRFSDLPLRTRTALVSIGYQKGfKLSRTAPTVWN 319
gi 123658195   79 DGQPLNISSDEALLVDEAFKAPFVDLLAANYTQA----------SGVDFAQLPAPMQTVIASVAFQYG-NLASRTPNFWA 147
gi 122388091  162 AENPLNLTAEEVKELDRAVKGEALDNVVKEYNTEverlnaadggSRPKFAELPREMQTVIASVGFQYG-SLKTATPNFFA 240
gi 122374230   77 SDTPLKITEQDAVEIDKYTKAAAVDRLCHLWQKAn---------PKQPFDALPTPCATIIASVAFQYG-NLAKRTPNFWR 146
gi 290985537  329 SKNPLSLSPAEAKAIDKAVMDKSLASLAKDYEAAaak----npnAVKNFKDLPSSVQSVAYSVQHQYG-SIKKATPGFFG 403
gi 505037574  801 NENPLSINEQEADTLDRAVKDEIFSDLQRRYNQn----------SDIPFNQLPPEAQTVIADVATQYGpNLENRTPNFWN 870
gi 908641450  904 IKNPLMVNDFELEILVSKVKKSETKRIVDLYNRIs---------KTTKFECLPWQAQTVIASLSYQYG-YLPSETENFWK 973

                  ....*...
4EPF_A        320 KVIAKDWN 327
gi 123658195  148 QVVARDWK 155
gi 122388091  241 QVTEQRWD 248
gi 122374230  147 QVTQGQWQ 154
gi 290985537  404 QLTKNDYK 411
gi 505037574  871 EVTEQRWE 878
gi 908641450  974 QAIEQNWV 981
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