Conserved Protein Domain Family
NupH_GANP

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pfam16768: NupH_GANP 
Nucleoporin homology of Germinal-centre associated nuclear protein
NupH_GANP is the nucleoporin-homology domain at the N-terminus of human GANP or germinal-centre associated nuclear proteins. GANP is part of the TREX-2 complex that links transcription with nuclear messenger RNA export, and it associates with the mRNP particle through the interaction of the NupH_GANP with NXF1, the export factor. This attachment mediates efficient delivery of mRNPs to nuclear pore complexes.
Statistics
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PSSM-Id: 318883
View PSSM: pfam16768
Aligned: 11 rows
Threshold Bit Score: 260.954
Threshold Setting Gi: 542255583
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612002099     2 NSNNPFGGQQSSLF-STPSGASLGTFQVQP----------PFR--------------------FGQPS----LFGQNNVG 46
gi 637250429     2 NPNTPFSGQQPGGF-QVPSGPATGIFPAQP----------SFQ--------------------FGQPP----IFGQNTGS 46
gi 765155915     2 NPSGTFGSSQGGAF-QAPGGTMKTSLFGQPfgqqnpssqgLFQppafgqqpvmnqsaghgnpiFGQTP----VFGQSQPS 76
gi 542255583    60 spafgqpSAQASAFgQPSAQASAFGQPSAQ----------ASA--------------------FGQPSaqasLFGKPPSG 109
gi 1040185508    2 NPPNPFSGQQPSAF-PTSASGSIGTFQAKP----------PFR--------------------FGQPS----LFGQNNTL 46
gi 332256679     2 NPTNPFSGQQPSAF-SASSS-NVGTLPSKP----------PFR--------------------FGQPS----LFGQNSTL 45
gi 558198097     2 NPPNPFSGQQPSAF-LTSSSSSIGTAQAKQ----------PFR--------------------FGQPS----LFGQNNTV 46
gi 752402028    13 NPTNPFSGQQPGVF-PASTSSSIGTFQAKP----------PFR--------------------FGQPS----PFGQNNTL 57
gi 351714697     2 NPVNPFIGQQPSAF-AASSSGTAGTFQSKP----------PFR--------------------FGQPS----LFGQNNTL 46
gi 537247948     2 NPVNPFSGQQPGAF-AVSSS-TTGTYQTKS----------SFR--------------------FGQPP----LFGQNNTL 45
gi 565312800     2 NPSTPFSGQPSGVF-QSSPGASAGMFSSQP----------PFQ--------------------FNQLS----LFGLNSGG 46
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612002099    47 S--GQNVGF----------A--QTSGFAQAAGVgQAPsg-atIGFPPTSGLGLYPT-QGQAPALTATSgPPGSSVPSNPG 110
gi 637250429    47 GalLKNPGF----------T--HLTDFTVTAGA-RSS-----LSLGQTPGFAQSYT-AAPTTSFVTSA-PTYSSVPSKQA 106
gi 765155915    77 StvSSAPAFgqqplgtfgnT--NASSFGQNSVSnQGSvlgpgSGFGQPPAFGVTSA-FG-----------SNPTLGQPQP 142
gi 542255583   110 ---VSSTGF----------GggTTPAFGQTGGPgQSSmfgqtPAFGQASGFGKQPPaIGQQPSGFGS--PLRPAVSQPQP 174
gi 1040185508   47 S--GKNSGF----------S--QASSFPAASGVsHSSsv-qtLGFAQTSSAGLFSG-LEHTPTFAATSgPSSSSVPANPG 110
gi 332256679    46 S--GKSSGF----------S--QVSSFPASSGVsHSSsv-qtLGFTQTSSVGPFSG-LEHTSTFVATSgPSSSSVLGNPG 109
gi 558198097    47 S--GKSSGF----------S--QISSFPT-SGVgHSSsa-qtLGFSQTSNVGLFSG-LEHTPSFLSASgPSSSCVPGNPG 109
gi 752402028    58 S--GKTSGF----------S--QVSSFPTSSGVsHSSsa-qtLGFSQTSNAGLFPG-LEHTPAFVAASgSSSSCVSANPG 121
gi 351714697    47 S--GKSPGF----------S--HMPSFGTPSGItHSSgq--tFGLTQTSSSGLFSG-LERAPPFVATSgPSSSSVPGNPG 109
gi 537247948    46 ---GKSLGF----------S--QVSSFATPSVVsHSSsl-ptFGVTQTSSVGLFAT-LESTPSFAATSgPSSSSVPGNTG 108
gi 565312800    47 ---VKNPGF----------T--HLSDF--TTGL-HNSsg-qgLGFGQLPGFTQSYS-LGETTTFVTTA-PMTASVTSKSG 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612002099   111 FSFKPPT---NLGAFPGTTSFGLSSGETASCGLGRPEFSFKPPESATFRPIFGAESESEKTQSQVTPGS----------- 176
gi 637250429   107 FSFKPPT---ALGPSHCPPNFGATSTDTSGSGFVGPDFSFKTPENAVFKPIFGTGSGQEKLANTGNQPS----------- 172
gi 765155915   143 LFFGQTSfgqTSSTSSSTSVFGQTPNITQSRGFGSSEFSFKPANDAIFKPIFSASPEPTNPQITPVSGS----------- 211
gi 542255583   175 LGFGQPS---SSSTSATTNTSLRGPG--QNRSFAPSEFSFRPANEALFKPIFSASPEPTNPTTTSLSNSafggsqttsst 249
gi 1040185508  111 FSFKSST---NLEVFPSTSTFGPEGGELPGSGFGKTEFTFKPLENAVFRPILANESEPEKTQSQITSGF----------- 176
gi 332256679   110 FSFKSPT---SVGAFPSTSAFGQEAGEIVNSGFGKTEFSFKPLENAVFKPILGAESEPEKTQSQIASGF----------- 175
gi 558198097   110 FTFKSP----NLGAFPSTSTFAPETGEVASYGLGKTEFSFKSLENSVFRPILGAESEPEKTQSQITSGF----------- 174
gi 752402028   122 FSFKSP----SFGAFPSTSTFGPETGEVASSSFGKTEFSFKPLENSVFRPIFGAESEPEKTQSPVTSGF----------- 186
gi 351714697   110 FSFKSPT---SLGVFSSTTAFGSEAGEVVSSGFGKTEFSFKPLENAVFRPILGTESEPEKTQSQITSGF----------- 175
gi 537247948   109 FSFKSPS---SVGVFPSGSTFGPETGEVASSGFRKTEFKFKPMENAVFRPILGAESEPEKTQSQIASGF----------- 174
gi 565312800   106 FSFRPPT---NLGNSQSTSAFGTVRGETSAGGFVRSDFSFKSSENAMFKPIFGTNSEQEKIPTSAASS------------ 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612002099   177 ----------------FTFSHP-----VSSGPEALGSFTFSQGSSGAGTGPNfTFSKP---Sg----------------- 215
gi 637250429   173 ----------------FTFSSP-----GTSGSGRLAPFAMSQASSSTASTSF-SFSKPl--Ss----------------- 211
gi 765155915   212 -----------------SFCAA-----GSQVSSS-TNAGFSFLTGSKAGPAGfNLSQPa--Pvsssssqnnslttacgdq 266
gi 542255583   250 tttsdfpllpksesldFSFSEPasapsISSQSNPLS----TDSSSGPATTLQfTFSQPa--Tl----------------- 306
gi 1040185508  177 ----------------FTFSHP-----ISSGPGGLAPFSFPPVTSSSTTNSNfTFSKPv-nT------------------ 216
gi 332256679   176 ----------------FTFSHP-----ISSAPGGLAPFSFPQVTSSSATNSNfTFSKPv-sS------------------ 215
gi 558198097   175 ----------------FTFSQP-----ISSGPGGQAPFSFTQVT-SSATKSNfTFSKPv-dS------------------ 213
gi 752402028   187 ----------------FTFSHP-----ISSGPGGLAPFAFPQVTSSSAANSNfTFSKPv-nS------------------ 226
gi 351714697   176 ----------------FTFSHP-----VNSGPGGPTPFSFSQVTSSSAPNSSfIFSKPv-nS------------------ 215
gi 537247948   175 ----------------FTFPHP-----VSSGSGSLTPFSFSQVTNSSVTSSNfVFSKPa--N------------------ 213
gi 565312800   171 ----------------FTFSSP-----SGAGFGKLTPFVMSQESSNSN-NTGfSFSKPvnsS------------------ 210
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612002099   216 ------NTPSSAFASASSGQNSEEEKRGPKPAFGSAGSSFTSFAGSLPGSVGEPFALSKAASKQGr-DDLGGQGGSLPGH 288
gi 637250429   212 ------NTSASSFSVALPSKTTEDDKKRPTVFFASPSSSFTSFSNSSTGSLLDPFQMNKTAKLQH--EEIVAPVEPHSLF 283
gi 765155915   267 tktlpfSFSQPAVPPISSTTASIKEPTTP--------SSF-SFSLKNFQTQPTPLSVGAGFDQLSafGEPKSKVETSLDk 337
gi 542255583   307 ------TSS--------STKAATTEPTTP--------SSF-SFTPKTLQPQAAQLFAGTTFGQSSafSETKTKEEASTDV 363
gi 1040185508  217 ------NNSSSAFAPALSGQNAEEEKRGSKSGFGSCNSSFSSFPM-SSVSGGESFPVSKTGVRQGc-EEAVSQVEPLPSL 288
gi 332256679   216 ------NNSLSAFTPALSNQNVEEEKRGPKSIFGSSQNSFSSFPV-SSAVLGEPFQASKAGVRQGc-EEAVSQVEPLPSL 287
gi 558198097   214 ------SNSSSPFALALSSQNVEEEKKGPKSLFGSLNSSFTSFPTSSSGSLGEPFPVSKTGARQGc-EETVSQVEPLCSF 286
gi 752402028   227 ------NNSSSAFTSALPNQNVEEEKRAPKSLFGSSDSSFTNFPI-SSGPLGEPFPVSKTGVRQGc-EERVSQMEPLPSL 298
gi 351714697   216 ------NNSSSPFNPALSNQNVEEEKRGPKSVFGSCNSNFSSFPV-SSGSLGEPFSVNKSGVRQGc-EEAVSQVEPLPGL 287
gi 537247948   214 ------SNTTSVLTPALSNQNVEEEKRGPKSVFGSSNSSFTTFPMPSSASLGEPFSGNKTVIRQGc-EEAISLVEPLPTP 286
gi 565312800   211 ------STSAVSFSTSLPSKTLADDKKRPMALFTSPGSSFSSFSNPSL-PLRDTFQVNKTNKMEH--EDLFIPSEPLPTL 281

                   ....
gi 612002099   289 MKGL 292
gi 637250429   284 GKGT 287
gi 765155915   338 ndsn 341
gi 542255583   364 Kvht 367
gi 1040185508  289 MKGL 292
gi 332256679   288 MKGL 291
gi 558198097   287 MKGL 290
gi 752402028   299 MKGL 302
gi 351714697   288 MKGL 291
gi 537247948   287 MKGL 290
gi 565312800   282 GKGM 285
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