Conserved Protein Domain Family
ATF7IP_BD

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pfam16788: ATF7IP_BD 
ATF-interacting protein binding domain
ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.
Statistics
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PSSM-Id: 318898
View PSSM: pfam16788
Aligned: 20 rows
Threshold Bit Score: 139.559
Threshold Setting Gi: 542187220
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883801    59 KENVKVMKTSE------Q-----INENACEALERHTALLEQVKHWIRQEICTINCNLFDKKLNELNERIGKTQCRSKHEA 127
gi 444512423  511 NVHSKRRRYME------EeyeaeFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKT 584
gi 847119312  533 SESSKRRRYEG------EeyeaeLQVKIT-ADDLNKKLQNVIQKMLEERLSTLQCVVFDKTLADLKTRVEKIEC-KKHEN 604
gi 874453234  392 SVHSKRRRYVGedy-eaE-----LQVKITARRDVDQKLQKVIQRLLEEKLAALQCAVFDKTLADLKMRIEKIECNKRHKT 465
gi 733869678  378 SVHSKRRRYVGeedyeaE-----FQVKITARRDVDQKLEKVIQRVLEEKLAALQCAVFDKTLADLKMRIEKVECNKRHKT 452
gi 823454520  392 NVHSKHRRYMGedy-eaE-----VQVKITARKDVDLKLQKIIQRLLEEKLTALQCAVFDKTLADLKTRMEKVECNKRHKT 465
gi 565322820  399 SIHSKRRRYLGdf--eaE-----FEVKITTKGDVHQKLEKVIHRFLEEKFSAMECALFDKTLEDLKSRVDKIECNKRHKT 471
gi 620970611  429 SIHSKRRRYVGeey-eaE-----LQVKITAREDINQKLQKVVQRLLDEKLGALQCAVFDKALADLKTRVEKIECNKRHKT 502
gi 5101772     20 NVQSKRRRYMEeey-eaE-----FQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKT 93
gi 947352609  563 NVHSKRRRYMEeey-eaE-----FQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKT 636
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883801   128 IAGELFIKIRRLQKRIKTVLS-SQGNCL-E--PNTLPSNTVcK---VTDSv--NLSVTQRSV----KSQ--SKRm--Ssv 190
gi 444512423  585 VLTELQAKIARLTKRFGAAKEdLKKRQEnP--PNPPVSPGKsAn--eVSSnnsMPYRNAGTVrqmlESK--RSVsesA-- 656
gi 847119312  605 ILYAIQAKIARLTKRFGAAKEdLKKRPE-QstAVNPASPGK-TvneASTAnnsMNYRSASTVrqmlESK--RNVgetVti 680
gi 874453234  466 VLTELQAKVARLTKRFGAAKEdLKKRQEnP--PNSPLSPVK-AasdTVSTt-nTTYRNAGTVrqmlESKrsVGVs--T-- 537
gi 733869678  453 VLTELQAKISRLTKRFGAAKEdMEEKQEnT--PNPSLSSGK-AassTANAn-nLTYRNITTVrqmlESKrnVGDs--K-- 524
gi 823454520  466 VLTEMQAKIARLTKRVGAAKEdLKKRQEnV--ANAPVSPGK-AapdTANGn-nATYRNAGTVrqmlESKrnVGEs--T-- 537
gi 565322820  472 IIAELQAKIARLTKRFGAAREdSKKKPEtL--QNTPHSPGK-AvsdTGSVn-sVTFRNAGTVrqmlESKrnVGDt--S-- 543
gi 620970611  503 VLTELQAKIARLTKRFGAAKEdLKKRQQnP--PNPPPSPGK-CtseAVGVn-tLTYRNAGTVrqmlESKrnVGEn--A-- 574
gi 5101772     94 VLTELQAKIARLTKRFEAAKEdLKKRHEhP--PNPPVSPGK-TvndVNSNn-nMSYRNAGTVrqmlESKrnVSEs--A-- 165
gi 947352609  637 VLTELQAKIARLTKRFGAAKEdLKKRQEnP--PNPPVSPGK-SaneVSSNn-sMPYRNAGTVrqmlESKrsVSEs--A-- 708
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883801   191 nHTPFNssekaSR-KIN-LP-----SACVEFVSE--SNddvml-----------------------isveNPNLTTPIAS 238
gi 444512423  657 -PPSFQ-----TPgNTEfVK-----CRHFVFQSGkaTGndsggvidltvdeeesgasqgvtvrvpqtttyvvnngltlgs 725
gi 847119312  681 lQPSTTaq-psTPtTSS-LPhrtpnTTTQVSVSQstANtslqgrappdwkliqqrinassigtpqnslnnQNKPLPPVTS 758
gi 874453234  538 -TTTFQ-----ASlST--VP-----ASTFVAPQIpgSG--------------------------------HPKPQTPVTS 572
gi 733869678  525 -PATLQ-----APvNP--AP-----PSSLAAPQTptSG--------------------------------HPKPQTPVTS 559
gi 823454520  538 -PATFQ-----APvNP--VP-----ASSLAASPAvvSG--------------------------------HPKLQTPVSS 572
gi 565322820  544 -TTTFQ-----SPvNA--VP-----AASLTTPQTpvSG--------------------------------HSKPQIPVTS 578
gi 620970611  575 -PAPFP-----VPvNT--AS-----STGPGPTQAagGG--------------------------------QPKPQTPVTS 609
gi 5101772    166 -PPSFQ-----TPvNT--VS-----STNLVTPPAvvSS--------------------------------QPKLQTPVTS 200
gi 947352609  709 -PPSFQ-----TPgNTvsstslvtppavvssqpkppatsgsltatsvlpapntatvvattqvpsgnpqptislqplpvil 782
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 81883801   239 DPTEIR---------KNTSR---NVSSSPNArsEVV 262
gi 444512423  726 tgpqltvhhrppqvhtepprpvhpaplpeapqpqrl 761
gi 847119312  759 APVMTSvip---attTATVV---GNSQVSGSssQPM 788
gi 874453234  573 -SPLTTtv-----lsTANTAavvGTSQVPSGstQQM 602
gi 733869678  560 -SPLTTav-----isTANTAtvvGTSQVPSGstQPM 589
gi 823454520  573 TSSLTTav-----lpTANTAtvvGTNQVPTGsaPSV 603
gi 565322820  579 -ASLTSgslttpvlpTANTAtvvGTSQGAGGntQPM 613
gi 620970611  610 -ASLTAsv-----lpAPNAAtvvATTQVPSGsgQPV 639
gi 5101772    201 -GSLTAtsv----lpAPNTAtvvATTQVPSGnpQPt 231
gi 947352609  783 hvpvavssqpqllqshpgtlvtnqpsgnvefisvqs 818
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