2K7M


Conserved Protein Domain Family
Connexin40_C

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pfam16791: Connexin40_C 
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Connexin 40 C-terminal domain
This is the C-terminal domain of connexin 40. It interacts with the C-terminal and cytoplasmic loop domains of connexin 43 and with the cytoplasmic loop pf connexin 40.
Statistics
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PSSM-Id: 318900
View PSSM: pfam16791
Aligned: 20 rows
Threshold Bit Score: 75.5757
Threshold Setting Gi: 47224738
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2K7M_A         9 VQGLTPPPDFNQCL------KNSPDEKF----------FSD-----------------F------SNNMGSRKNPDPLAT 49
gi 551495716 269 SASCTPPPDFDHCL------TAPRSMNPmts-----iaSHP-----------------F------NTRMALQQNSANLAT 314
gi 973191648 257 SRACTPPPDFNQCV------TAPETG------------CNP-----------------F------NNKMANQQNSVNLAT 295
gi 190338256 260 NRACTPPPDFNQCL------TSPPSSPTlqthsllhptCPP-----------------F------HDRLAHQQNSANMVT 310
gi 557022836 270 SGSYTPPPDFNHCV-------NSPNGKY-----------NP-----------------F------NNKLASQQNSTNFAT 308
gi 597730826 282 SQTCTPPPDFNQCL------AASGRGPT----------SPPqlhhhhhlhpihsnyqpF------NNHLAHQQNSANLAT 339
gi 528490054 274 SQTCTPPPDFNQCLrsnqgpTSPPHL-HshhlhhihqtCQP-----------------F------TNHLAHQQNSVNMAA 329
gi 617380577 269 SASCTPPPDFDQCL------TAPRSMNPmts-----iaSHP-----------------F------NTRMALQQNSANLAT 314
gi 768915740 275 PPQSTPPPEFSQCM------MGSTH---------------------------------FlplafpNHHLahqqnsenmat 315
gi 47224738  268 PPPSTPPPDFSQCM------MGSTH---------------------------------FlplafpSHHL----------- 297
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2K7M_A        50 EEVP-NQ-EQIPEEG-FIHTQ-YGQ------------K------P-EQ-PSGASAG-HRFPQGYH--------------- 89
gi 551495716 315 ERHH-SC-DNLEDEEdFLRIR-YEQ------------L------PaEL-PNGCSPL-PLLHSGFL--------------- 356
gi 973191648 296 ERHQ-SR-DNLDGEd-FLQMS-YMQ------------G------S-DS-SNTSAPP--NLHNGFC--------------- 334
gi 190338256 311 ERHR-GQ-DYL--GVnFL--S-FSQ------------T------PtET-PNSCASP-SFLSSDF---------------- 347
gi 557022836 309 EQDQ-SQ-EEL-GSGqFIHVN-YEH------------N------K-EA-SNSSVPP-LHLSHGFN--------------- 348
gi 597730826 340 ERHHcSH-DNLEVCEdFLRMS-YGHpsaavsmscghgP------P-EVlPSAPSTPtSNGSTSFI--------------- 395
gi 528490054 330 ERHH-HShDGLEPAVdFLQMH-YGS------------PearvrsE-MT-PSTPSTP-S-SHPGFF--------------- 376
gi 617380577 315 EQHH-SC-DNLEDEEdFLRIR-YEQ------------Lp-----A-EL-PNGCSPL-PLLHSGFL--------------- 356
gi 768915740 316 ekh---kiaaaveeatllqMGcYSH------------G------W-QK-TNPS----QIQDDPYLrndnsrygpgsreis 368
gi 47224738  298 -------------------MGcYSH------------G------W-QK-SNPS----QIQEDAYLrkdnncygpggrkms 334
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
2K7M_A        90 ----------------------SDKRRLSK---ASS-KARSDDLSV 109
gi 551495716 357 ----------------------KDKRRLSRtsgTSS-RARQDDLAV 379
gi 973191648 335 ----------------------KDKRRLSKnsgSSN-KLRVDDLAV 357
gi 190338256 348 ----------------------EDKRRFSKssgTSS-RMRPDDLAV 370
gi 557022836 349 ----------------------KDNRRLSKaskSSS-KGRSDDLAI 371
gi 597730826 396 ----------------------RDKRRLSKtsgSSSnRVRPDDLAV 419
gi 528490054 377 ----------------------RDKRRLSKtsgTSSnRLRPSDLAV 400
gi 617380577 357 ----------------------KDKRRLSRtsgTSS-RARQDDLAV 379
gi 768915740 369 csqiqnggsdrlllcpsgahnqKDKRRFSRtsgTSS-RTRADDLSV 413
gi 47224738  335 cpqiqnggsdrlllcpggalsqKDKRRFSKtsgTSS-RTRADDLSV 379
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