3A2A


Conserved Protein Domain Family
VGPC1_C

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pfam16799: VGPC1_C 
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C-terminal membrane-localization domain of ion-channel, VCN1
VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.
Statistics
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PSSM-Id: 318908
View PSSM: pfam16799
Aligned: 7 rows
Threshold Bit Score: 78.7821
Threshold Setting Gi: 1326184164
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
3A2A_A         11 RQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIE---RLNKLLRQHGLLGEVN 58
gi 1020957516 189 QQVSKLKQANLKLATRVEQLEHSCLEKEQEIE---RLNNILKQHGLLIQQK 236
gi 971420812  188 QQVSKLKQVNLKLATKVEQLQHSCVEKEQEIE---RLTRMLKQHGLLSEQT 235
gi 565320699  192 QHISKLKQANLQLRTKVQQLESSCAEKETEIE---RLNSLLKQHGLL-SQD 238
gi 395513713  209 KQLSKMRLINHQLSMKIRQLESNHSEKEQEIE---RLNKLLKDNGHLe--- 253
gi 444724943  568 QQLLRLKQMNIQLAAKIQHLEFSCSEKGSLSDchiPLMKLKSSIGLLLQQE 618
gi 620942002  369 QQLSRLRQANLQLVAKVQHLEFSCNEKEQEIE---RLNALLKQHGLIn--- 413
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