Conserved Protein Domain Family
PilZ_2

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pfam16823: PilZ_2 
Atypical PilZ domain, cyclic di-GMP receptor
PilZ_2 is a family of cyclic di-GMP receptors found in Proteobacteria plant pathogens. PilZ_2 forms a tetramer that adopts a novel 'house-like' construct, with a central pillar domain of the four vertical alpha3 helices, a roof-top domain made up of the eight inclined alpha2 and alpha4 helices, and four corner-stone domains making up the PilZ domain. Cyclic-di-GMP is a universal secondary messenger molecule extensively involved in regulating bacterial pathogenicity, and its downstream receptor appears to be this PilZ domain.
Statistics
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PSSM-Id: 318923
View PSSM: pfam16823
Aligned: 5 rows
Threshold Bit Score: 135.707
Threshold Setting Gi: 503300517
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491555671  48 LRSLALVEDSRVDEHDDRN--EASLQLQRLEAKLDLAMVLLGRLVRQQGQELTLRPVRWSRRGI--RLQlg-pRSG-ASP 121
gi 918007173  52 LRALAVIDDGAARSDEQDP--QGEPALLRMEAKLDVLTLLVAELAAAQERGDPRQPLVWSARGV--ELV----VSD-PPA 122
gi 502680269  48 LRGLAQVEDLRAEDGSDERg-EASLHLQRMDAKLDLMLVMLGRLARQHEDTLPLRPLRWSRRGI--RLElekhSGA-LPG 123
gi 503300517  46 LLGLAQVEDLRSDEPGEEKrgELPILAQRLDAKLDLVLLLLGRLVRQGNPALPATPLRWSVRGLrlQLP----AGTdLPA 121
gi 505261404  66 LAAIAALEERRADSGEDDS--PLMQEILRMDAKLNVLVEIVNSLLVPDSVLPPRQLLRFNAIGA--LLP----AGL-APA 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491555671 122 GQ-AGLVRLQPSDWLPDH--IDLPVE---V-IAE---AADGGgghyL--WLRFQRLGDGLEMAMERHLFRLHRRQVAEAR 189
gi 918007173 123 AGqQGLLRMRASDWLPTR--LLLPAQvlaV-QAE---SAGTR----V--WLAFVQLSPALQSALERHVFRIHRREVAQLR 190
gi 502680269 124 AA-G-LLRLQPSDWLPDH--LELPVQ---VlDEA---TDSGR----FhlWLQFETQPPSMEEAMERHLFRLHRRQIAGSR 189
gi 503300517 122 VD-S-AGAVRLQPVDWLPddLELPVI---V-SATaqdADASW----A--WLRFPALPQGLEDAMGRHLFRMHRRQVADAR 189
gi 505261404 137 GG-GLLLRIRFDLCRSLP--LELAAQ---V-QRQ---FDDGR----V--FVIFAPLGEALSDAIERLVFRHHRRKVAGAR 200

                 .
gi 491555671 190 R 190
gi 918007173 191 R 191
gi 502680269 190 R 190
gi 503300517 190 R 190
gi 505261404 201 Q 201
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