4EQ6


Conserved Protein Domain Family
CSM2

?
pfam16834: CSM2 
Click on image for an interactive view with Cn3D
Shu complex component Csm2, DNA-binding
CSM2 is one of the components of the yeast Shu complex that maintains genomic stability during replication. CSM2 complexes first with Psy3, and their L2 loops confer the DNA-binding activity to the Shu complex. The Shu complex binds to recombination sites and is required for Rad51 assembly and function during meiosis. The heterodimer of Psy3-Csm2 stabilizes the Rad51-single-stranded DNA complex independently of nucleotide cofactor because Psy3-Csm2 is a structural mimic of the Rad51-dimer.
Statistics
?
PSSM-Id: 318933
View PSSM: pfam16834
Aligned: 14 rows
Threshold Bit Score: 209.871
Threshold Setting Gi: 74605378
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4EQ6_A        10 ITIWPSPTKNKLCQFIKQNLsk------ehVVTQLFFIDATSSFPLSQFQ---KLVppt-lpENVRIYENIRINTCLDLE 79
gi 74609982   12 LTLWPVAPDIDLAQYIYQFLtsev---gtqTEKEVYFTDSINSFPIHQLQ---ELVn----eSNQSIYENIKINTALDLH 81
gi 367000313  11 LTAWVPDSTTAVTEFITKALlnsaessapdIFLKLYFIDATNSFPISQFQ---ETIpi--cdENNHIYENIRITTCLDLN 85
gi 366990689  27 ITAWVSPKKIDLAKFISSALq--------dQPSQLYFIDATNSFPIREFQ---RETpv---aTNKDVYDNIRIITCLELE 92
gi 156842381  11 LTVWGSPSSLEIAKLISTTLnaqi---ennTPLQLYYIDATNSFPLTQFQ---KLVpv--neDNKRIYDYIRIMTCLDLY 82
gi 365983662   9 ITAWISSTGSHLSQYMSSHLrpte---ksnEVRQLYFIDATNSFPLQQFQ---NLIpyngedENKRIYDNIRIITCLELG 82
gi 363753502   5 sklkdDALTSHLLNFYYKHLsts----dceRLPQLVYIDCKNSFPVRSFQaklDQIprpphyTRQLLFESVRIMVCLELA 80
gi 255718291  13 VVLWFDSDEECISKMMATFLtvds---aeqSAKTLYFIDAMDRFPIKEFC---RLVpp---kENAAVYENVRIMASLDME 83
gi 367012091  12 LSIWQSPPQKNLAKFVRQIIgs-------lnNRTLYYIDATNSFPLQEFQ---KIIa----vEQKEVYDRIRIITCLDLS 77
gi 444320577  12 LSIWVDPLPIILSNLMISILqe-------nDDIEIQFIDSNNSFPINQFQ---KIIqn--kdIDSRIYERVRISTCLDLN 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4EQ6_A        80 ELSAITVKLLQILSMNKINAQRGTEDAVTEplk------------------------------iiLYINGLEVMFRNSQF 129
gi 74609982   82 ELSSIIKKNTESLILKKIQNKKTNDLKPFQi---------------------------------lSVINGLDVMFRSTLV 128
gi 367000313  86 ELLININKMTQLIAINRFKKQQKSDNSAKQsikdqqg---------------------icrsgilVFINGIEIMFRNSQI 144
gi 366990689  93 ELTILVNKIIQTIQLNKIERQKKKSQNNSHhndiqff----------------------pdlkmrVIINGLEIMFKNTQF 150
gi 156842381  83 ELNRITNKMLQLISIDKIQKKQNIKHRNKEpdslhn------------------------tygilVFINGLEVMFRNTQM 138
gi 365983662  83 ELAMVLNKIIQSIQLNKIKRQKNTTTQSEKpkegn--------------------------lnilIVVNGLETMFRNTRF 136
gi 363753502  81 DFEDIVRKLYQNIAADRATRHHSHSNNPPAdsdinnr----------------------lakqtlVVISGLDVMYRTSQV 138
gi 255718291  84 ELSSVVSQVVSSAQMSHSTRLRDPSAPQPQv---------------------------------cVVIRGLDVIFRNTAL 130
gi 367012091  78 ELSKTLNQVVQVLNIDKIQQQQRRKEKDGEntnv----------------------------eilLILNGLEIMFRNTQM 129
gi 444320577  80 ELKIISDRLVQINNIRKIRHEQKKINRKNEsnnitkdinnedstkdsndnannsnilnksdtpsfLFISGLDVMFRNTQL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4EQ6_A       130 KsSPQRSHELLRDTLLKLRVMGN--Den---eNASIRTLLEFPKEQLLDYYLKKNN-----Nt---------RtssvRSK 190
gi 74609982  129 SfTNEQAHLMLRDVMLRLRQVCN--Eyd--csPLTFKIILLFNRSDVMELLPKQRH-----Sa--------aH----QQK 187
gi 367000313 145 KsSNEKSHYLLREAMLKLRVMAN--QytpseeETSLKTVLQFPVTEVFASTSKDLS-----Qn--------kK----NGK 205
gi 366990689 151 KqDSETTHSILRDILLRLRVIAN--Es----eGTQMQTLLLFPKDEFKISVPVGDT-----G---------------RYK 204
gi 156842381 139 KeSQERTHLFLRDILLRIRAIANqpKdd---nSIELRSIVTFPSNELNKSLNKSSD-----N---------------PAK 195
gi 365983662 137 KeNVEVTHSVLRMALLKLRILSN--Er----nGYHLRSLVLFPLEEMKNLSTK------------------------QLK 186
gi 363753502 139 L-DPTTAHRHLNDALLRLRMLSN--Ka----pSTDFEVHIILPHSEFQKSCLTDGH-----Atarmp-pennN----HAK 201
gi 255718291 131 K-DQARAHLLLKDIMLRVRMMAN--Td-----PLLLKAVLLFEVQQKPRGINLPGSndssqNa--------pP----PSK 190
gi 367012091 130 EcSPSESHLLLKDLLLKLRTIAN--Nce--vgEPMLRTVLTFPKEELLKFNSSNSQ-----S----------H----GNK 186
gi 444320577 160 GkSAEEAHSLLKECLLKLRIVGN--Tii--ddQFFLRTIIGFPINELAVPESNSNH-----TfsgsyksidkI----GNK 226
                        250       260
                 ....*....|....*....|....*
4EQ6_A       191 RRRIK-------NGDSLAEYIWKYY 208
gi 74609982  188 KMKYNna----mEGNSVGEFVGKYY 208
gi 367000313 206 RMKNKqh----iKGNTVGEYICKFY 226
gi 366990689 205 RMRSNh------NGNSLGEYVCKFY 223
gi 156842381 196 RPKSInl----iKGNTIAEYVTKFY 216
gi 365983662 187 RLKSSsnr-gqnDGSSVGDYVCKYY 210
gi 363753502 202 RAKPNwh----gHGNTLGDYIIRFY 222
gi 255718291 191 RPRSDyrsgapnNLNSIAVYLMKFY 215
gi 367012091 187 RLKSTi-----tNANTLAEYVAKFY 206
gi 444320577 227 RVRRSl------KGNTLGEYVSKYF 245
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap