4DT1


Conserved Protein Domain Family
PSY3

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pfam16836: PSY3 
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Shu complex component Psy3, DNA-binding description
PSY3 is one of the components of the yeast Shu complex that maintains genomic stability during replication. Psy3 complexes first with Cms2, and their L2 loops confer the DNA-binding activity to the Shu complex. The Shu complex binds to recombination sites and is required for Rad51 assembly and function during meiosis. The heterodimer of Psy3-Csm2 stabilizes the Rad51-single-stranded DNA complex independently of nucleotide cofactor because Psy3-Csm2 is a structural mimic of the Rad51-dimer.
Statistics
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PSSM-Id: 318935
View PSSM: pfam16836
Aligned: 15 rows
Threshold Bit Score: 181.044
Threshold Setting Gi: 149247836
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DT1_B        10 IRIYPLSNFITSTKNYINLpnelrn----------------liseeQESKLGFLHIIESD------FKPSVALQKLVN-- 65
gi 74606124    7 CKVYSLDQFTSPYQYTCEV---------------------------NGKKCTRIHVVQES------LRGNGKTRTIVNtv 53
gi 254578564   7 CRVYPISNFYHAVPQSLTLpsci-----------------------gshCVSFVHLIEHN------FKFTPFKRQIWNqc 57
gi 366997374  20 CRVYPLSNFYHPSPQSITLpntli-----------------sntdnDKPHIGLLHLIEHD------FKMSNFKKQLFNh- 75
gi 444314935   7 CKIYPLSKFYKPNYQYYQLppgik-----------------pnenlDTSKISKLHLIEYG------FEITPLKRSLLTtm 63
gi 363750141   7 CKVYPLDRFLKPHLYTLNWlpel-------------------svddKRKPVRFLHIVEKSmglldrWKASFLRQLL---- 63
gi 302308966   7 CKIYSLARFVHPRQHSLDWlap---------------------gtaPRKSVHVVHVVERTmgelaaWRPRTLARLL---- 61
gi 365991030   7 CRIYPLANYIRPELKFINIsndliinnnksiisvndhldddknddnNTNKVALAHLIEHE------FKLTTFKKKLLIdl 80
gi 403214524   7 CKVYPLGKYITPAQRSLDLppaght----------------itngkPHSTHSRVHIIVKD------IRHGQIIQDILT-- 62
gi 410075197   7 CRIYPLSNFLKPKRNAINLeglninn--------------snditiNNNESQSLHLIEHS------FRKSKFKEQLV--- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DT1_B        66 ------CTTGDEKILII-----------DIVSIWSQQ-KQrqhg-----------aiymNSLSCINITGLIVFLELLYDS 116
gi 74606124   54 ----reQCEGNGLILNIssmprndhndnDLLETYPEF-QQ-------------------TNLSMLQFDSFIQFMSQLCTD 109
gi 254578564  58 i---ecSVNDGSSILVI-----------DIISEWKKI-IQensqg----------vhymNSTSICNMEGLQNFLMQLQAS 112
gi 366997374  76 ------LTTSNASYLII-----------DITSTWKRFlLSsssasa--------slmymNSTSILSFEGLINYLVQLNDH 130
gi 444314935  64 -----lMMEDVGNVLII-----------DIVSIWLGT-IEmmnmkqk------kkinylNCIS--NIKELNNFLSQLIET 118
gi 363750141  64 ------DQNDPATVLVI-----------DAISIWSRM-LPhkses---------qvhylNNPSILQFSGLVGFLAQLCES 116
gi 302308966  62 ---------EGGAVVIV-----------DCVAVWGRA-VAqhassg--------rihyvRDAGVLSFSGLLGFLAQLADA 112
gi 365991030  81 itipnhEKNGKNSYLII-----------DISSTWKQY-LIelfdrennqtnfttsinymNSFSILNMDGLINFLMQLNGS 148
gi 403214524  63 ------QSAGHGCVLVV-----------DNYGN--NH-PPsakdth--------tvrhlVSST--RVEDLTAYLRDVPSQ 112
gi 410075197  64 -------SNNFEHIIII-----------DIISIWQDdkf-----------------nviN--SIYTFNELINFLTKFNDS 106
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DT1_B       117 -PMDAL-R-RCQ------VDNFN----F-QLRGIVIDNLS-FlnFE------SDknydvinlSK---FEKLFKILRKLRE 172
gi 74606124  110 -PVTAL-S-RCQpq--nsETSTS----K-QLAWVLIDNLS-HlsMD------PK--------FD---AKLLNRSIRLVQQ 161
gi 254578564 113 -PLEAL-Q-RCLi-----KDRLD----K-QISGIIIDNLS-YlaHD------LS--------S----YSALIKILKQLRR 160
gi 366997374 131 -PTTAL-Q-RSLs-----INNEPlqltL-PLSGIIIDNLS-YlpQD------PP--------Q----FKILTNILKLLRK 182
gi 444314935 119 -PIVAL-R-RCQq-----FENVDeviqR-RLDGIFIDNVS-YlqDFnedqkgNS--------QM---YDELNKMIRKVRE 177
gi 363750141 117 -PDLAL-RsRCDi-----HASLD----A-PLKTVILDNLSaYyfQE------NA--------S----LETLRKLLETLHA 166
gi 302308966 113 -PAATLrR-RCRa-----PATAP----A-PLAAVVLDNIS-AyrA-------PP--------AA---LGALRRALEHLQL 161
gi 365991030 149 -PIDAL-K-RCQqypstsSDSID----QyQLSGIIIDNLS-YisSS------SS--------SStstFPLLLKLLKLLRK 206
gi 403214524 113 lPTEA----RTM-----------------PLQGIIVDNLSlCrrSR------GP--------GA---DAQLLETLRKLQR 154
gi 410075197 107 -PLATL-S-EY-------GISMD----T--VEGIMIDNLS-YigNL------NN--------KS---IVILIKILKLIQI 152
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
4DT1_B       173 FLGCWIITKSFPTDFYNGIEN------TLVD-------KWSikrksgvtlypTKLPdsYMKGMDLII 226
gi 74606124  162 TFGSVVISTSLPLSFHGGIEStfkhqsTKCA-------SGD-----------RLLP--YFNESDIIL 208
gi 254578564 161 TFGCWILTIGYGLEYYDGVENst---sTPNR-------TGAl----------TKLPasYINEMDVII 207
gi 366997374 183 SLGCWIMTTSYGLEYNQGIENti---sTSAS-------NSN-----------TYIPlnYTKEMDIVL 228
gi 444314935 178 VFGCWVVSISYGNEYYEGVEGcl-----nVK-------SHSis----------gVPisFLNGMDMIV 222
gi 363750141 167 TLGCAVVTFGYGIEYYEGVDNty---pT--R-------PSEikg-----pwpTRLDysYLKAMDSVL 216
gi 302308966 162 AHGCAVLTVGYGIEYYEGVESsf---pT--R-------AGEvgp------wpTRLDhaYLASMDAVV 210
gi 365991030 207 SFGCWIFTTSYGISYYKGIENsl---eSSPSsssihlqQHSkk-------lpTYFPesFINGMDMIL 263
gi 403214524 155 RYGCWVVTVSYGIGFa-----------TAGG-------QQLaqt-----aypTSLPlqYLNECDTVL 198
gi 410075197 153 NFGCFILSTSYGLEYYEGIEN-------FQR-------MKNlnl-----kypTLLPmnYLLEMDTIL 200
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