Conserved Protein Domain Family
CBM60

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pfam16841: CBM60 
Ca-dependent carbohydrate-binding module xylan-binding
CBM60 is a family of xylan-binding modules found in conjunction with xylanase enzymes in many bacterial species that attack plant cell walls. Xylan is the major hemicellulose component of most plant cell walls, and is one of the most complex carbohydrates targeted by CBMs. CBM60 modules are evolutionarily related to CBM36 domains as both show circular permutation in the beta-barrel folds. CBM60 targets xylan but is also able to bind cellulose and galactan and thus contribute towards breakdown of the plant cell wall. Recognition of the ligand is conferred primarily through the polar interactions of O2 (oxygen) and O3 of a single sugar with a protein-bound calcium ion.
Statistics
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PSSM-Id: 318939
View PSSM: pfam16841
Aligned: 39 rows
Threshold Bit Score: 77.7074
Threshold Setting Gi: 503966320
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81835467   389 SISVYAAGAEN-TE---TIELWIDGQRAQtwqniGG-Di-D---TG-EFVKLDFEADS--T-VD----------I-SQIQ 444
gi 122388732  200 QLSVRAWGTQA-PPdpvRMQWLLDGVVVA-----SL-Dv-P---AT-TPTVYTQPVRV--DsPG----------Q-KRFT 254
gi 81660662   270 TLVLSLSGDQG-GDepvRVEV-TDGRRAI-----PV-Ev-K---ES-EPTDKTVAFRL--G-KG----------T-RQID 322
gi 506389663 1635 TLTIRARGTAA-GGvwpSMALRINGAIVQ-----RW-Tv-T---ST-TFQTYTYTHPT--P-LD----------AdQTID 1689
gi 918006853  345 TFTVQAQGSQA-GDepaRCRIQLDDQKAE-----VH-Dv-P---GDrQNKTITWKATL--P-AG----------K-HALK 399
gi 503331369  266 vLSIRAWGDQA-GSepvKMGLLVNGQQVK-----VF-EvkA---DR-ESRAEVFEHQVrtR-AG----------T-NKIA 322
gi 502891039   79 TLTVRARADLC-KGsp-vATLKAGGAILG-----TI-Dv-T---SS-SWATYRVSGTV--P-PG----------P-NTLT 131
gi 501563076  509 KVTVYAAGDAY-KGd-pQFRLLLDGKAFG-----SAqTv-TmdrGD-GWQQFNFNLPA--G-TD----------P-DRIS 565
gi 501563269  403 TVKVYAAGNSY-RGd-aEFRLLADGQQVGav-qdVT-Tq-R---GT-GWQVFTFDLGD--G-DLgdgdlgdgglP-DRLS 469
gi 500106379  302 SLVIRAKGDQYrGAp--EMRVSVNGKVVS-----KV-Av-T---AT-SWTDYTVPFSG--P-AG----------T-YTLS 354
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 81835467   445 IRFTNDLYQANg----AIDRNVRIDRVELDGTSYQTEAETVYST 484
gi 122388732  255 VRFTNDTYDPAt----STDRNLLLDWMEVRSPAPTSVATQRHLR 294
gi 81660662   323 ISFLNDYYVKD-----KIDRNLHVHHVKVSGVEQRSQfvsspdl 361
gi 506389663 1690 LLFENDGVVGN-----D-DRNLFIDTIQIGSQVIHAGQRGVSYD 1727
gi 918006853  400 IAFTNDFYDPDsenpkRRDRNLYVTASRVEGPKELKREHYSESH 443
gi 503331369  323 IVFLNDFYQPEt----RSDRNLHVSAIVAKGPLNGPPPEPTAFQ 362
gi 502891039  132 IEYANDYFEFL-----RCDRNLYVASVTIDDAGAPESCPANQFR 170
gi 501563076  566 VEYFNDLYGGK-----GMDRNLEIDKIVVGNQTFDPGKAGfltg 604
gi 501563269  470 IQYANDLYGGP-----GKDRNLEIDRIEIDGTVIDPGKAGRMFC 508
gi 500106379  355 VAFTNDRYSRR-----NGDRNLRLDTVTVVSAVVDPEPPTPPST 393
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