Conserved Protein Domain Family
ApeC

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pfam16977: ApeC 
C-terminal domain of apextrin
ApeC domain was first identified from two apextrin-like proteins (ALP) of the amphioxus Branchiostoma japonicum. Our functional studies show that amphioxus ALP1 and ALP2 are important anti-bacterial effectors, and that the apeC domain of the ALP1/2 mediates the bacterial recognition by binding to bacterial muramyl dipeptide (MDP). Further analysis shows that the apeC domain is present in various proteins from cnidarians, molluscs, arthropods, hemichordates, echinoderms and amphioxus. The apeC domain is also found to form different domain combinations with other domains (in press).
Statistics
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PSSM-Id: 319046
View PSSM: pfam16977
Aligned: 32 rows
Threshold Bit Score: 157.458
Threshold Setting Gi: 353232735
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241783054  427 WPPGSYGLPMPVSGCPSsVGFT-WATGCRFHDIAydvvEDDKIRHWSD-GM----------KLKGGLqEDG---GVEQCF 491
gi 156388835  146 WPSGSYGLPKPMTGCHGdK----WREGFRYHDTE----NNDNQNNQSA-IS----------HLAGNV-TLH---GIRQEF 202
gi 156366803  611 WPKGRYGLPRPRSDCPMnSGFA-WTTGSRFQAL-------YPASYSSA-KI----------HLYGSV-TSE---GVTQSF 667
gi 156366803   28 WPAGSYGLPCTSSGCPQsTGVV-WLTGTLYQPLY----EYSKG---SV-PL----------HINASI-TRD---GITRSF 84
gi 405954415  155 WPKGPYGLLMADSGCPSnDMPTaWSNGSRLH--------YSNGNSMPSfSF----------HLYGNY-SRI---LFQHHF 212
gi 762106322  429 WPSDGFSMLKPRNGCPDgF-----KEGSLVMGV--------PGADHSE-QY----------HLDTRL-TDD---ELTVRF 480
gi 405965461   43 WPGGTYALPTSMFGCPEtEAKG-WSISYVNLTLP----ESSQQQEWNM-KNpgpltdviepNILGPY-HYR---ALQMNF 112
gi 390353038   28 ststRYAIPAPSTGCADn-----WKAVHLTVAYP----NLTTLTIISD-EF----------HVSLVV-EKDeadNVDMRF 86
gi 156362576   24 WPSGTYGLPMPVSGCPDdETVS-WKKGWTYHDTE----DDNNQNQRSE-VY----------HMPGNF-SKH---GIQQKF 83
gi 156391839  157 WPAGTYGLPRPRAGCPWsEGFD-WQIGYRFHDTE----DDSPENQHSN-GY----------HMAGNV-SDD---GIRHEF 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241783054  492 CVKK---DD----APPS-----------------N-ATTpWSPGNYCILQVG---------------DTCPDGFQSGYIT 531
gi 156388835  203 CIHE---GG----EGEE-----------------R---L-WPQGQYCIYKKG---------------ALCPAGLNEGWIR 239
gi 156366803  668 CIKN---TT----DGDQ-----------------V-RPE-WPPGKYCIFAKG---------------NTCPKSMRGGWYL 706
gi 156366803   85 CIKN---ST----DSDT-----------------S-RPN-WPMGRYCIYAKG---------------DECPHGMSMGSMY 123
gi 405954415  213 CIHDhagDP----FSMP-----------------RyQTY-WEEGKYCIFRVS---------------GQCPNEFHEGFIL 255
gi 762106322  481 CTKE---QT----TGGD--------------------TE-WEPGQYCILRTD---------------RKCPNGFEDGHIV 517
gi 405965461  113 CVKT---PTyfedKEGN-----------------MtSTE-WPKGQYCLYNFN---------------GSCPKDFTNGTMT 156
gi 390353038   87 CMWD---SE----KVDSietgvavadgfgqgdalS-FTT-LPDGRYCVYGVGlaeanmdkgkwewsqGSCPKGFESGF-- 155
gi 156362576   84 CIKD---TP----KGGS-----------------E---F-WPEGKYCIYKKG----------------VCPANMKDGYVR 119
gi 156391839  217 CMKT---NP----IGQD-----------------R-----WPEGKYCIYRKG---------------PNCPEGLEKGFII 252
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241783054  532 WMDQQPtapD--AHNRVSGTVPRGRYTaH--------------NT-TLYFCCRNDGSPDVAIRLPTDLPFYLL-QYDAGT 593
gi 156388835  240 WDDENS---DidFPNSEGGSLPEGIYG-E--------------NT-VIYYCCDGRGDTSTPIWLPSGGPFYLM-PFISKT 299
gi 156366803  707 FDDRLDl-tP--SPNRTMGTLPDGVYN-E--------------NT-LYDFCCSTGGSTSDAISLPLDSPFYLF-PYQSAM 766
gi 156366803  124 WNDRLA---Fv-DPDYTRGELPRGVYT-V--------------NT-LMYFCCSTAGRRDTAIPLPVATPFALF-PL-DPY 181
gi 405954415  256 MDDLNGl--E--FMQSVNGSVPDGVYE-K--------------DT-GFFFCCRSDGDVETPIVLPKDQPFVLFmANGSTE 315
gi 762106322  518 VDNE-----K--NPHVASLPLPDVDVD-K--------------NV-RLNFCCRNDGSWFDQIYLPSSQPFVLF--ERGYE 572
gi 405965461  157 IRGY-Q---F--TEQDIGGQIPGNKGQ-N--------------QTlLLQFCCREDGNHLTPIQLPKEFPFIMFqSQSADR 215
gi 390353038  156 -----S---T--FPFRTSSALPDNFVN-NlvpipspfslfrknNT-MVHYCCTQNGDVNIPIELPFIIPFFLF-PLRSKE 222
gi 156362576  120 WDDEQSe-iD--LNDKHQGDLPDGVYD-Ks-------------HT-TINYCCSTKGNVNNPIQLPALKPFYLL-TYGSAQ 180
gi 156391839  253 WDDENK---D--NQNSAGGTLPEGHYG-E--------------DT-RIEFCCSGTGDWDQAIRLPRDRPFYLY-AYESNK 310
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 241783054  594 CQKVQGMSVFEQSFHFMEDDVGarsplDTDAPGGMpkfkegHPR--VdsTLFDRGLV-LYYCYY 654
gi 156388835  300 CQSVHRFKATLEFRHFDDEDHA-----NRNQHSGA------VPY--Gi-TEDKYNTR-IYYCYY 348
gi 156366803  767 CQKVKGALINTEYIWFHT---D-----MKNVYQPP------LPF-----KLTADSSK-LFYCHY 810
gi 156366803  182 CQKVIGAYASLEYIEFDT--VN-----YDNIWKTP------HPY--L--GRKSYDPT-MYYCYY 227
gi 405954415  316 CQSVRGMLHELEFFLFDDENVN-----TKVAQNGS------LPE--V--KRGTNNTV-IYFCYY 363
gi 762106322  573 CQEVKDMMTSSEWLMIEN-DLS-----GEYEVVGS------APD--V--TVRQDNKYfINVCYY 620
gi 405965461  216 CQEIESMTSQRDFFYMT--NQN-----NNWEFKGA------LPMf-D--TTTLKNSVgVPYCYY 263
gi 390353038  223 CQRVRGMKHRLEYVIW-----P-----SMKYNGGV------HPYtnD--THFGEN-T-FYYCYY 266
gi 156362576  181 CQKVSGTKVTSEFIKFDDDDEG-----NTDYADGA------HPY--Gp-SEDPFNLK-IYYCYY 229
gi 156391839  311 CQKVEGMRSASEFLKFDDEDRG-----NVDYEGGE------YPY--Gv-HKQDKDHT-LFLCYY 359
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