3VOQ,3ULB


Conserved Protein Domain Family
SIN1_PH

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pfam16979: SIN1_PH 
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SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
SIN1_PH is a pleckstrin-homology domain found at the C-terminus of SIN1. It is conserved from yeast to humans. PH-domains are involved in intracellular signalling or as constituents of the cytoskeleton. SIN1 (SAPK-interacting protein 1) plays an essential role in signal transduction, anf the PH domain is involved in lipid and membrane binding.
Statistics
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PSSM-Id: 319048
View PSSM: pfam16979
Aligned: 64 rows
Threshold Bit Score: 93.0249
Threshold Setting Gi: 195121168
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3VOQ_A        13 HHYKSFKVSMIHRLRFTTDVQLGIS--GDKVEIDPVTNqk-asTKFWIK--QKPISIDSDLLCACDLAEEKS-------- 79
gi 15214339  394 PMHRTFRLNIIDKRFFKSDVTLGIS--GERIEIDQCKN-----AKFWPQ--KKPVSTPIDFVAHCEILERRH-------- 456
gi 642912707 319 PLYKSFKVYMINKMRAKVEIHLGIS--GEKIEIDPV-Qk---nSKFVLVk-QKPINHDMDMIAWCEPIETTK-------- 383
gi 470363911 527 HQYKSFFVYIKHKFSANQEVMLGID--GNKVDIIPQSTq------gFFAk-TKLVSYQMDDIVLCQPIDEKSktlkpgvs 597
gi 321460082 298 TDYHSFKGFLLHKVRPNTEITLGIS--WDQVEIKPCPTsrsvtTLLWSRpnLKPTRLPIEVIVDCVPMQTLP-------- 367
gi 340381998 374 HLYTSFSVTMLHRMRSNTRVQLGIDpqRERVEIQPIESl---kG-FLAKp-LKPMKYDINEISSVDILEEKP-------- 440
gi 195430464 404 PIHRSFRLNLIDKRFFKSEVTLGIS--GERIEIDQLKS-----TKFWSQ--KKPISTPIDLVVHCEIAEKRQ-------- 466
gi 195121168 427 PMHRTYRVSIIGRPFFKYDATLAVS--GERIEIDQLNN------HFFMH--RKPLSTPIDLVAHCEIVDQGQ-------- 488
gi 195029905 415 PMHRTYRLTIIDKRFFKSDVTLAVS--GERIEIDQHKN-----TKFWTN--RKPVSTPIDLVAHCEIVEQRQ-------- 477
gi 195382960 421 PMHRTYRVSIIDKRFFKCDVTLAVS--GERIEIDQHKN-----TKFWTQ--RKPVSTPIDMVAHCEIVEQRQ-------- 483
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3VOQ_A        80 -P--ShaiFKLTYLS---------------------------------------------------------NhdYKHLY 99
gi 15214339  457 -LkaL---LRIWLKSnssspsfstgctsapinasvttlna--------gsgsggiahspsspghssglfsssNirFKHYD 524
gi 642912707 384 -S--NkmtFKIIYSHsfanaenv------------------------------------------ssptlqsSasFKSYE 418
gi 470363911 598 tK--S---FRFVYYNg--------------------------------------------------------Ne-FKSNY 615
gi 321460082 368 -A--S---VAIMYYDt-------------------------------------------------------dKrkWRRLR 386
gi 340381998 441 -P--Na-vFRIVRLTk--------------------------------------------------------EgsVKNID 460
gi 195430464 467 -YkvL---LRIWLKSnstssstfsasnctsvpldgsvttlntggsgsgsagiahspsspnhstltnssflssNirFKHYD 542
gi 195121168 489 -LraM---LRIWLKAnssislpisctsapsmtsitsgng---------vyspanprspwmhsssrfgattisNirFKHYD 555
gi 195029905 478 -LkaV---LRIWLKSnsssgiatsctsapsgstatlsgsnvgg-gfghspssprhssgssssspfglfssvaSirFKHYD 552
gi 195382960 484 -LkaL---LRIWLKSnssssmttsctsapstasiatlipgsgsvglihspasprhqathsssspfglfgsasNirFKHYD 559
                        170       180
                 ....*....|....*....|..
3VOQ_A       100 FESD-AATVNEIVLKVNYILES 120
gi 15214339  525 FDTD-THTAEQIHNKLNCILEM 545
gi 642912707 419 FEAD-QSIAEEIVNKINLILDL 439
gi 470363911 616 FDAKgAEEAKEIVTKINYILQS 637
gi 321460082 387 IECDs-KTIEQVVAKLKFILEI 407
gi 340381998 461 FEAP-HNITKKIVAKLKLIISd 481
gi 195430464 543 FDTD-LHMAEQISNKLNCILEM 563
gi 195121168 556 FVTD-VHTAEQIRNKLNCILEM 576
gi 195029905 553 FDTD-VHTAEQIRNKLNCILEM 573
gi 195382960 560 FDTD-VHTAEQIRNKLNCILEM 580
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