Conserved Protein Domain Family
Actin_micro

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pfam17003: Actin_micro 
Putative actin-like family
This is a family of microsporidial-specific proteins of unknown function. There is distant homology to the Actin family.
Statistics
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PSSM-Id: 319066
View PSSM: pfam17003
Aligned: 7 rows
Threshold Bit Score: 361.796
Threshold Setting Gi: 269860034
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74697661   15 IEQITTPNKNIQSFFMRSDASYCVGEKYRMANYRTDEQIVHIV-VWNNRLIV--ETESIDLDDFFYLASMN--------- 82
gi 484856964  17 IGQINIVSKYVSCSYGRFDNSYYVKDDYRFHNYRKDEKIITII-LNNSILTI--DNCNFDLGNIFYLSKFN--------- 84
gi 300706041  25 IDQINIVSKYITSSFGRSEVSHFAKFNHKFPQYRNSEEIITVI-LNYDKLII--NNDTV-----FITTDMSnir------ 90
gi 378755353  13 IDGIQTANKNIHSYFMKNDNSYCVDSQHRYAGYRKETDRTYIV-V------I--SKYESVTGDYTYKHNSAspeieclig 83
gi 269860034  13 IEPISTPNKNITSTYDKKEESYLVNSKYKFPQYTFN-SIVGII-TEKKFILYkpNDKKVETELLFANIELYydk------ 84
gi 667632085  11 LHTITTANKNIHSFFMRTDVSYFVKESECYPAYKKDDDRVLVLrMvgdeieI--YECEDSNDEYEYDDRGVkepedgaqe 88
gi 672237280  13 IDGIQTANKNIHSYFMKNDNSYCVDSQHRYAGYRKETDRTYIV-V------I--SKYESVTGDYTYKHNSAspeieclig 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74697661   83 --------------------------------TKRFGS-LEECVGWLGNQvsgVLERLEIR-PRNSFVSLIFHDLLNRTE 128
gi 484856964  85 --------------------------------TKVFKS-LQHVIGELELR---IRKEINFN-PKDHFLNFVFNNTFTRSE 127
gi 300706041  91 -----------------------------kycDSIYKS-ITNI-------------------PKGSFVSFIFHGVLGRSI 121
gi 378755353  84 er-------------------kdnlqtkkvslSNLLKT-IKEIEYSLP-------GMEEVH-AGEIFIGLVYPDGLNRVS 135
gi 269860034  85 ------------------------------feKHLINTsTPFIFRKLESEl-vHFIKSHCN-PLNLFIQLIFSDFYTKDQ 132
gi 667632085  89 ggegvndresnveaynsmsniriaknikrcriDGLFEgnvlapvs---sthllfkLYNNLPcLKDGFVCLVFKDTLRRSE 165
gi 672237280  84 er-------------------kdnlqtkkvslSNLLKT-IKEIEYSLP-------GMEEVH-AGEIFIGLVYPDGLNRVS 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74697661  129 ILAICNLFINILSFKGILITPRSLSQAIGTLSPSCIVVSLYEHHTT-VCLVEDFWMLDGICVSRESNE--GFGLV--DSV 203
gi 484856964 128 LIGLVDMFINIMGFKGILLKPYALAMCLGLGVQHGLFINVYEKHTT-VFLVDDYWLIDSFTISKEKNI--GFNCI--DDE 202
gi 300706041 122 TVSLVDMFINQIGCKGLLIQPYSLNMCIGLGIQHCILVDEYSTHTN-VYIVDDYVLHDCFTVKKSINY--SVSVClpDDQ 198
gi 378755353 136 ILNMVDSILNHSRFKGVLLLPLSLSVCLGMGFSNAVVYIEADK--T-VSLIEDNCIFDTFTEGRPGST--TLY-----GS 205
gi 269860034 133 IIILVDLFLKVCGFRGIQLL--QIGFCIGIKLRKSTLALEYVNHITgYTFIDDYTTVDSFCTDNIVSIipNISLA--DNE 208
gi 667632085 166 LLFLINVMLNYKSGKGMLLLPESLALCMSLTIQSAIVIHNQEDttY-ISVIEDYVLTEVKKLKEEKAS--NITlf-raEE 241
gi 672237280 136 ILNMVDSILNHSRFKGVLLLPLSLSVCLGMGLSNAVVYIEADK--T-VSLIEDNCIFDTFTEGRPGST--TLY-----GS 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74697661  204 DFVDEF-SRIKVFEEKNIFSCSRCDYKDDAEEKMEAHFLSSHGKEECHpdvdp--------------------------- 255
gi 484856964 203 DFADEY-HKIKFLQDSVYFLCNLCDFRHTSYSKALEHVRFTHVIQDKCecmvkfteeqkrkkektpfn------------ 269
gi 300706041 199 DYVEDY-QKLRMIEDIPYYGCKICDYKSKVLFKVQEHLKINHFFSEND-------------------------------- 245
gi 378755353 206 DVVEEFlRKEEPAKSVEEMVCFMCSAAFE-ISEFSMHFLNKHM------------------------------------- 247
gi 269860034 209 DIADEF-CRLKTLNYNNKFSCKKCDVKEDSIDKIYKHLERDHKIKDNT-------------------------------- 255
gi 667632085 242 EFVDEF-DSWEEFKLDKTFRCDVCGTWFVK-ESIFMHVIKKHIKngkcecrksknskseevvggvdereieennqnvdds 319
gi 672237280 206 DVVEEFlRKEEPAKSVEEMVCFMCSAAFEI-SEFSMHFLNKHMI------------------------------------ 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74697661  256 ----------------------------------------------gehfKMHIRMYEEE-EGDI--------------- 273
gi 484856964 270 -------------------------------slsnslsdpslprlsdehiATHISEYKNE-HKDS--------------- 302
gi 300706041 246 --------------------------------------------------KNMIFKYENN-HEDC--------------- 259
gi 378755353 248 -----------------------------------------------------IDIYANQrHSDTllhkcrpkeepaqpe 274
gi 269860034 256 --------------------------------------------------QEWVYELKNKsFNEL--------------- 270
gi 667632085 320 tngkdtgdrsgademgghsesfnrsdsnvsflnvetikganindsikqhvkdhiT-YIFK-GKSV--------------- 382
gi 672237280 249 ------------------------------------------------------DIYANQrHSDTllhkcrpkeepaqpe 274
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74697661  274 ------HELIAKRANYVLSK-EKMKKIASRVIVFK---YSGVGLSEECLKKAFEEY------------------------ 319
gi 484856964 303 ------ILEVIKRLSLVYHNiDKLQKISLKVHLNDpksLNNFAIEELIQKLSNLYG------------------------ 352
gi 300706041 260 ------IQEILKRLRFLYFNlERLKRMNIRVVHNN---FNN--INDLCEQLKFLYN------------------------ 304
gi 378755353 275 eeaptdVVAVGKSMLQKLSPaERVAKIRSTVIFIT---EQDVPEPETVLNTAADTApdtaldavpdtaeagpsegtlpee 351
gi 269860034 271 ------IEFI---FTNKLKKlEN-NKYTVQLNF-D---TTNNIISESNTSI--NYI------------------------ 310
gi 667632085 383 ------YEKIGHFLRAYITK-ERLKKINTI-IT------DEVTIARMKEQ--FSTF------------------------ 422
gi 672237280 275 eeaptdVVAVGKSMLQKLSPaERVAKIRSTVIFIT---EQDVPEPETVLNTAADTApdtaldtvpdtaeagpsestlpee 351
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74697661  320 ----------------GVDPEVSmyEEPVENMI------------M------------GVMRVFSGLDCIKELWMTDKEW 359
gi 484856964 353 ----------------NVTLVVI--NENPFDLI------------L------------RGMKVFNQLELAKECWLTDEEW 390
gi 300706041 305 ----------------NVIP-----IQADDSVI------------F------------KGNELFNTLELSKECWITDKEW 339
gi 378755353 352 seettrgfeqsaknnsAMLPPII--EDAASSSVicihdskkaqtaW------------NGVFALVNIEPSKDLWLTDKEW 417
gi 269860034 311 ----------------IIQPK----------DL------------L------------SSAIIFKELDTSKELWLTDKEW 340
gi 667632085 423 ----------------NYVD-IS--K----ASA------------W------------RGAKDLMRIDVAKELWMTDREW 455
gi 672237280 352 seettrgfeqcaknnsAMLPPII--EDAASSSV------------IcihdskkaqtawNGVFALVNIEPSKDLWLTDKEW 417
                        570
                 ....*....|....*.
gi 74697661  360 SSAGLRVLKEKVLFII 375
gi 484856964 391 RSVRLRILKEKVLFNL 406
gi 300706041 340 NAGKLRVLKDKILFNL 355
gi 378755353 418 QSVGLRVLKEKVLFPI 433
gi 269860034 341 EIGRKRILKEKVLFYI 356
gi 667632085 456 NATRLRVLKEKLLFYL 471
gi 672237280 418 QSVGLRVLKEKVLFPI 433
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