Conserved Protein Domain Family
CAF20

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pfam17052: CAF20 
Cap associated factor
In eukaryotes, the translation of mRNA is initiated by the binding of eIF4F complex, which is composed of eIF4E, eIF4A and eIF4G proteins. elF4E-binding proteins (4E-BPs) are involved in translational regulation through their interaction with eIF4E. There are two elF4E-binding proteins (4E-BPs) found in S. cerevisiae, Caf20 and Eap1. This entry represents Caf20 (also known as p20), which competes with elF4G for binding to elF4E and interferes with the formation of the elF4F complex, hence inhibiting translation. It is needed for the induction of pseudohyphal growth in response to nitrogen limitation.
Statistics
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PSSM-Id: 319109
View PSSM: pfam17052
Aligned: 25 rows
Threshold Bit Score: 127.156
Threshold Setting Gi: 254564825
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187470650   3 KYTEEQLFAIKEEtS--YVPQPQILSAFNELIEQVKEhahqqqlqyqQQQQQQQgfsgigsgvsgpgaqkwrngdtyidE 80
gi 187470652   3 RYTVDELFHLKPTeS--L-PVQFDAEEFKAIIEKVKQ----------IQALKEE-------------------------E 44
gi 74608544    3 KYSIDELIQLKPSeT--L-KVSFDHVEFRNIIEKVVE----------LQKLKEE-------------------------E 44
gi 410074805   3 RYTIEELFQLKPSeP--VQQVDFDAVEFKAIIEKVKK----------IQALREE-------------------------E 45
gi 367003353   3 KYTAEELLHLKPEeT--L-PVDFDAEEFRAIIENIKQ----------IQALKEE-------------------------E 44
gi 403216848   8 sYTIDELFQLKPAaApaELAVNFDAVEFCALVAKVKE----------IQAAREE-------------------------E 52
gi 444316106   5 RYSIEELLQLKPSeI---QPVDFDAVEFRAIIEKIKQ----------VQLLKDE-------------------------E 46
gi 255713942   3 RYTEEELLQLKPEvD--V-PVNFDIDSFRAIIDKVKE----------IQGLQEE-------------------------E 44
gi 187470653   3 KYTIDELFQLKPSvT--L-EVNFDAVEFRAIIEKVKQ----------LQHLKEE-------------------------E 44
gi 366989491   3 KYTIDELLHLKPSeT--M-TPNFDAVEFRSIIEKVKQ----------LLALREE-------------------------E 44
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187470650  81 HGHERSYHHMNRRRPSRSN-NgekKPFF---N-K-KKtEVVVDEDGWETFTPVQHahr----gsiGEDGSEEKSKFRDSV 150
gi 187470652  45 FNAHG--GHFNRRRSSHHH-Hg--RPKVkhtK-P-K---VTTDSDGWSTFEAANKk---------vNEDEESENVsva-- 103
gi 74608544   45 FHSH----HGNRRRSSHHHm----KPKIkhnK-P-K---VKTDADGWSTLEPATAg---------hEEESSSSATpaaaa 102
gi 410074805  46 FLTS------NRRRSSHHH-Pt--RPKI---KhN-KP-KVTTDEDGWSTFEPKSAt--------tNDESAIEDD---DTN 100
gi 367003353  45 YAAH---GFTNRRRSSHHY-Ht--RPKV---KhN-KP-KVTTDADGWSTLETAKGe--------eGEAGEESDEEDSAPF 105
gi 403216848  53 YMA----HNGGRRRSSHHFaHt--RPKV---K-HmKP-KVKTDEDGWSTFEPKMPs----------ETDLTEGNKQKSSD 111
gi 444316106  47 FAHG---GHFNRRRSSHHY-HnmmKPKI---KhN-KP-KFKTDENGWSTLDTSAKde------ssAIEDDEQSSKSKKES 111
gi 255713942  45 Y------QQFHRRRSSHHHg----RPKIkhtK-P-K---ITTDSDGWSTFENTVArrksnaagngSEEDLPVKEQpvi-- 107
gi 187470653  45 FNSHHV-GHFGRRRSSHHHg----RPKIkhnK-P-K---VTTDSDGWCTFEAKKKg---------sGEDDEEETEttpts 105
gi 366989491  45 FHSAHPLGY--RRRSSHHHg----RPKVkhnK-P-K---VTTDEDGWSTLETKKSe---------dEEGAIAVDGEKPFI 104
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 187470650 151 sgssgsgagagagagaasgsaGGVRARPNNKNLGSSKQVDPRQIASTKQTRTFNAFEALE 210
gi 187470652 104 ------------------vvpETLKVKPNNKNISSSRPADNKDIIADKQTHSFNAFAALE 145
gi 74608544  103 tt-------------ktgapqETIRVKPNNKNISSSRPADNSDIIADKQTHGFNAFAALE 149
gi 410074805 101 vks---------------raqETVRVKPNNKNIASSRPADARDIIVDKQVHGFNAFAALE 145
gi 367003353 106 vat---------------istETIRVKPNNKNISSSRPADNRDIILDKQTNTFNAFAALE 150
gi 403216848 112 slt---------------aaqENVRVRPNNKNMGSSRPADAKDIIADKQILGFNAFAALE 156
gi 444316106 112 spg---------------sfhEVVKVKPNNKNISSSRPADTKDIVADKQTLNFNAFAALE 156
gi 255713942 108 -------------------aqETLKVKP-NKNITSTKPADARDIVTDKAVNNFNAFAALE 147
gi 187470653 106 tv------------pvatiaqETLKVKPNNKNISSNRPADTRDIVADKPILGFNAFAALE 153
gi 366989491 105 atatsa----------ssiaqETMKVKPNNKNISSSRPADTKDIVADKQIHGFNTFAALE 154
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