Conserved Protein Domain Family
DUF5128

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pfam17170: DUF5128 
6-bladed beta-propeller
This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.
Statistics
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PSSM-Id: 319188
View PSSM: pfam17170
Aligned: 11 rows
Threshold Bit Score: 276.124
Threshold Setting Gi: 498502326
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189432033  12 FLLITLVDCt-SRKGESH---SVV-EV-VDFGNV--Q--TCKSSELIRvERFLPLETSDRCLFGSIDQLEVWK-DRIYLL 80
gi 695397029  11 LLLILFCSC--AQEKKTH---GNG-II-ISFEKD--T--DVNADSILE-LSFLKLQTKDSCLVKNVGLIRELN-NCLLIL 77
gi 497546136  11 lcllFSCGL--SQN-ENE---EHV-YV-INVDEA--E--KKGFSSMFDsVAYIPLETTDECEIGRISRVLYHN-GKYIVV 77
gi 806521530  11 ICFLFSCSL--PQN-RNL---ENV-YV-LNLDEA--N--NNDFYSMFDsVTYISLETQSDNEIGQISRILYHY-GKYIVT 77
gi 492482951   7 LVMISLASI--LIACENR---SEEwDV-VDFGND--C--TVGLQEHLE-CRFIPLETKDSVLLKDLYRVCWVD-DRIFVF 74
gi 491875915  12 ILFILVC-C--NKNNGAT---SFE-RI-TLKNEY--V--D--LSKYLD-FEFIPLETTKDNLIGIISNIKMTN-DRIFIF 75
gi 518426603   8 lilifllAC--QEKSNFE---NIS-VLqIDLDTS--K--NGKFSDLFDdIEYILLVTPEDFPLVEPHNIKFSD-KRIFVR 76
gi 491935978  39 fllvlvSSC--RRSSTINtpnGEY-KM-IDCQEI--NggKFKLSSIASsFSVIPLETNDSCLIGGISKLEFYD-GKIFVL 111
gi 494929567  15 LCTVLSCGEnaRQADGLS---DKT-HI-INIPEDlsN--ISHLDSVFSdITFIPLETREECLISYISTIKIAD-SLIYI- 85
gi 524516907   8 FIMLLFACT--SRDK--N---EIP-TL-SVDLHS--S--DVSFEDLFSkIEIIPLETSDSCLLVDVEKIVHVD-SLLYVF 73
gi 498502326  11 ILLVVLAGC--GENKQST---DDLiTV-DVSKSYpkK--ELILQDFMD-VEYIALETTDEFLTQ--GLVKDVGkKCLLVT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189432033  81 DTYkT--NA-VLVFSaTDGKFIHKIEGTGNGPGEFLSPHSFWIDRSDGSLYILDRMMSKLLKYDLESLDYEEEIKLPDLA 157
gi 695397029  78 DSA-N--SN-LYVFN-KSGAFVNQIGKKGSGPGEYIFLSSFFVDNNKNYIAAIDVAQDKVLYYNATDFSFLYERRLPFST 152
gi 497546136  78 DEL-T--NT-VFIFT-EDGRYYSKIQAAGNGPGEYAQMADIAIDKFEEKIKILDAMQVKVVSFDLDG-HFTGETKLPVSP 151
gi 806521530  78 DML-T--NR-VFIFN-EDGKYYSKIDAIGNGPEEYVQITDITIDKYNERIKVLDAMQGKIVSYDLEGYS-VGETKLPVVP 151
gi 492482951  75 DRS-DeiNA-LFVFS-DQGNFITRVGLRGQGPEEYLYLTHFFVDEKERILTLVDFGGTALLRYDLDTYQYISTQDVADYF 151
gi 491875915  76 DSY-Ka-NA-LFVFD-KKGKYITQIGSPGMGPGEFAYLAGFDIDIINNNIIIYDF-KRKFMYYDLDTYELISEKNLDICC 150
gi 518426603  77 DWA-T--NQ-LFIFD-EKGRFERVIKAMGKGPGEYFQMNDFQI--KGESIYILDFFLNKIIQFDF-SGSFIQEIRHDLDN 148
gi 491935978 112 DKM-H--SArLYVFD-TQGEYKFAIGKRGSGPNEYMQINDFSIDKEKNLIYVLCDKK-KLFTYSL-SGQPLGTITLDFF- 184
gi 494929567  86 NNN-R--KQ-LLVFE-KNGKFKYQIGNQGEGPGEYLEINDYIINKDN--IELLDFK--KILTYSLTG-EYLETKNFDLLN 155
gi 524516907  74 DSR-R--PA-LYVFD-EKGAFVRQISRWGDGPGDHLLISDFMVDKNQQTIGLL-SPNGYMGIYDLCG-KFIRQDVLPAKP 146
gi 498502326  80 NRN-Nd-GD-IFIFDrKTGKGVRKINRQGPGAEEYTRINEIILDESNDEIF-VKSPGNKILVYGLYG-KFKRCLNLDWEV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189432033 158 p-lA--F----CVPTEGDYL-Y-Y-F--PLRK--N-D---LFCGKQYVEADKEG-NVLSTAYDALASGKILH-GNAAPFY 217
gi 695397029 153 ---S--C----CLQLEDGNL-L-W-N--SREY--T-Ds--KLSDFYFVVTDSLF-DIIDYKMNKEFKSGYTT-GPSQMIY 211
gi 497546136 152 ---S--Pi--rFCQVDRDKY-A-Y-D--FERS--F-Ye--KEWQYNLSVNQEDFtGEISKFMPYDKPLSICF-SSRVTLQ 213
gi 806521530 152 ---AplH----FCQVEKEKY-A-F-D--FQRC--S-Se--KEWQYNLFISSEYLsGEISKFLPYDKPLDVCF-SPRVTLQ 213
gi 492482951 152 ---V--D----CAPLDKENW-I-WyY--PLGF--A-Tp--QRENFYLKATDRKG-EQDALLGPAYFTSGHTI-NGSKTLH 211
gi 491875915 151 ---C--D----FMALPQGKYaF-F-H--TNGF--EcLg--KQKNNYVLITDTLF-NPINAYYKAEFTTPIVSrNSSSNFY 212
gi 518426603 149 ---N--N----FYLGSEYKL-F-F-N--SYNI--D-Hg--R---FNFLRENEEG-LKGFVSFEKDKENIVNF-NSHTGFI 204
gi 491935978 185 ---A--D----AMEYQKNQL-H-F-V--CDRL--D-Rg-------NLIVTDIKG-RILYEDFPNKRMGDNLL-MLIHPFS 238
gi 494929567 156 dtvY--CnaegFCHSPLGGY-Y-F-WggTSGIknY-Ns--EQIRYMMYHVDNNI-NITKGYFPIEHGTGTAH----TRFK 222
gi 524516907 147 n-yY--A----VASLSPDRW-V-F-W--SCVR--E-De--D--GITVVGKDSL--NTVSGFWRNDRILDM---GSLNPFY 202
gi 498502326 155 ---S--S----VFDYDKNNL-IcY-D--MSDY--H-NkgkDRSKAYHVILSKQ-----DGSITREIFIPFKT-INAP-IV 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189432033 218 SYGGK--IRFCPYFSNC--IYE----WMND-SLKVCREMKWGNRTLPEIAVFEK-----SEDSGd--vMREILSSDYIRF 281
gi 695397029 212 KVGAN--VFAYTPFDLT--IYR----VGTS-EIVPAHSFSFEGTDIPSLDFLNK-----ISNQGnsnyLYDLIQSDYISY 277
gi 497546136 214 DVNGE--ILFIPLYSPT--VYT----IESS-ELKPRYTFDF-GDKWVSQEFID------TEWKDaiefMNKLNNANFVHY 277
gi 806521530 214 EIDDE--VLYIPLYSPT--IYT----IDSF-ELKPRYTFDF-GDKWVDQDFVD------IEWKDagefMNKLSRTKYVYY 277
gi 492482951 212 AFAGD--WYAHFPFTPE--VWK----VKDG-MLEPAYKVRFGDKSMPPIEYVKE-----K-GRGgrdfSGDLFRSGYVNS 276
gi 491875915 213 KLDNY--YYIYNHLLPY--VYK----ITDR-AFEPIYELFLESYQFPTMDFLKK------ETKGksdyTKTIDNHDFISS 277
gi 518426603 205 EDPHNpfIYFNIPYSTEvaVFN----KKNG-NLSRIIQFDF-GKHNTETRVLKE-----RSTTIqeiqSQRNLVVDLAAF 273
gi 491935978 239 KQDSI--LLYRIYLDNK--IYE----MQSDhRIKVAYEVNFGEE---SIDFED------LEDIPhrevKKKLANSRG-KI 300
gi 494929567 223 SYKDT--IIIDPYLKEYn-IYQ----IDDKgTLSSRYFFNFG--KNAYTQKLPV-----GRNKGkh-eTYEDFSKYVISC 287
gi 524516907 203 EYHDN--VYFATAYQNA--VYK----LTEK-GLYPVYCWDF-GKDGINDEMLQKyclieNEGKRndelIKDLSDGTL--P 270
gi 498502326 212 TDGSN--FVASYSYQIR--LSHgqwtLMDA-SADTLYNYAPDGTLNPFIVRTPS-----AHTMQpevfLYMGIHTDR--Y 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189432033 282 LYV-YENRAALAVKYYV-QK--DLYL------S--VYNKSSGQV--A--N--VkaAAVQDDLGLGGLFPMPVGTD--EDL 341
gi 695397029 278 YSV-EETERDLFVCYMK-NK--EKYI------G--LYDKDTDRT--Y--NypI--KIFQDQLKVGELNYFSIGSV--DDY 337
gi 497546136 278 FNM-LESGSHIYGEFMY-GE--NKYY------L--LIDKETGHR--F--L--Q--QGMKDEK--YQYEKFSMCCV--GNQ 333
gi 806521530 278 FNL-LESGSHIYAEFMY-KE--NKYR------L--VIDKETDHL--F--L-----QRETEAYKCHYTEI-PMCCI--GNK 333
gi 492482951 277 FGL-LETEQILHATYMC-DK--VTYF------G--FYDKDRKEA--F--SyaF--PNFIRATGLTGF--YGICGVy-KDY 335
gi 491875915 278 FGL-YETKDFLWIPFHKsNM--PPCT------G--FYDKKEKKG--YilS--L--SDYFKSINLGVL-PFAKGNT--DEC 337
gi 518426603 274 FPF-----KNHYITIVK-QGaaKMHY------L--LLDQTFQKI--G--Q--F--QHLENDLDQMKFEGYPWTFS--ENE 329
gi 491935978 301 KYL-TENRNYIQLIFFD-KQ--MPCV------A--VYDKRQGVTrsY--T--F--ENCVDDLTGLQYPLFEFTKG--QDE 360
gi 494929567 288 EDF-QETEKWLHISFAH-EN--KAYS------A--LFNKGTQKC--Y--L--L--SAANPHLKTDELRFWGAYASw-GEQ 346
gi 524516907 271 FCMkFHRENDLYYYVSL-QK--GLGTvnkhinV--FYRKQDGST--F--V--F--EKLAENL-----SITPLLFT--EDY 330
gi 498502326 280 YFM--ETVKNVFN-FEK-GN--GFYT------DqlVYEKEEKNL--Y--Q--V--AVYNNDYAEKRTVAMTAKSInrEIE 339

                 ....
gi 189432033 342 LVGS 345
gi 695397029 338 HVAP 341
gi 497546136 334 FVIP 337
gi 806521530 334 FVIP 337
gi 492482951 336 FIGK 339
gi 491875915 338 LICE 341
gi 518426603 330 LVYS 333
gi 491935978 361 FIAI 364
gi 494929567 347 LIMP 350
gi 524516907 331 IVSK 334
gi 498502326 340 NVTS 343
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