Conserved Protein Domain Family
Fuz_longin_3
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pfam19038: Fuz_longin_3 
Third Longin domain of FUZ, MON1 and HPS1
This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.
Links
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Statistics
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PSSM-Id: 465955
Aligned: 36 rows
Threshold Bit Score: 39.9315
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9VR38       417 ELRHFLYKPKSTAQLLCPMLR----------HPYKSLTELERLEAIYCDLLHRIHNs-------------------sRPL 467 fruit fly
EFX89267     288 NVLSYLVVNTEKRRSLSSLSPhsts--gdahSHLTAVRKRDILRTFYKTIVGTMINlpsatqs--------dsedasHDS 357
XP_001604141 287 AILGFLLVNYKIGKFVLSGNAqh------skNHVSGTHRLDTIRTFYHHAVETFLLpvddnsekee--epnksahqfKGA 358
CRL02569     279 SVIGFLLINSRLKKYFISKNIqq-------vVGKRSSHRMDILRAFFHKSVYTEDFgal---------------sepVKV 336
XP_013398686 285 SILGFILINRESHRCLCTVEPmeeds-srqgKTMSIYRRREILRAFYKSVVRTIFTppqsdmdste-tadtlhtrlkHKA 362
Q2HZX7       287 GILGLLLINRDMNKSLYTVQAhpmeemqktdLKLTLEQRRSALRSFYTLAMSRYFPseradgkntlpseesfqsgfsHSA 366 tropical clawed...
Q9BT04       295 DILGLLLLHLELKRCLFTVEPlg-------dKEPSPEQRRRLLRNFYTLVTSTHFPpepgppek-----tedevyqaQLP 362 human
Q3UYI6       295 DILGLLLLHLELRRCLFTMEPsk-------dKEPSPEQRRRLLRNFYTLVATTHFPpepgpaek-----qedtvypaQMP 362 house mouse
XP_011442063 285 NTLGFLLINKETNRCLCSISPtfng--ghpdETLSPSQRKEVLMSFYKRMVGTFFSsvvpgse-------sgpsefsHQA 355
KDR11428     505 GLVHFLYIDRFNHRITAPSLDf--------sSEETTSLTKKKIWAMVEFSRAHLQE---------------------GHT 555

Q9VR38       468 KLIYEMKE------REVVLAWATG-----------------------------------------------TYELYAIFE 494 fruit fly
EFX89267     358 KEVFMNFE------YYSLHALISE-----------------------------------------------MYLILVLYP 384
XP_001604141 359 KETYWCSE------YHKCHALKET-----------------------------------------------DHIFCVLYT 385
CRL02569     337 PEQYYTSD------YHKCHALIKD-----------------------------------------------ECILCVLFV 363
XP_013398686 363 LETYIVSE------THKCFAMNTN-----------------------------------------------PYELYVLYS 389
Q2HZX7       367 HQCYTISS------SCKCYGMKTE-----------------------------------------------LHLLFLLLK 393 tropical clawed...
Q9BT04       363 RACYLVLGteepgtGVRLVALQLG-----------------------------------------------LRRLLLLLS 395 human
Q3UYI6       363 RACYLVLGpg---mGWQLVAVQLG-----------------------------------------------LRLLLLLLS 392 house mouse
XP_011442063 356 MESYITTE------THKCYAMMSG-----------------------------------------------PHQLFMVYG 382
KDR11428     556 AIMWKDTTf-----SYAYFLWFEDssasplkpkifptaalknfprpgilcgdfyqklaefcfpktslckvhCYELYCVHL 630

Q9VR38       495 PVVDKATVIKYVDKLIKWIEKEY 517 fruit fly
EFX89267     385 SGLHNHYLRSITRSTLKILTHEK 407
XP_001604141 386 STVPTHTMRLITQKTLKILLADK 408
CRL02569     364 SAVPTHTMKFISEDLLVKLLSEK 386
XP_013398686 390 IHIPTYALRSTTTKLLSSLIKEK 412
Q2HZX7       394 PEVPTFSMRSIANKTIAAFTKDF 416 tropical clawed frog
Q9BT04       396 PQSPTHGLRSLATHTLHALTPLL 418 human
Q3UYI6       393 PHTPTHGLRSLATRTLQALTPLL 415 house mouse
XP_011442063 383 EVIPTYAMRSITQKTLSLLTKDR 405
KDR11428     631 GLATSSCVLEQSRRLAATIWEVT 653
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