2VGM


Conserved Protein Domain Family
pelota

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TIGR00111: pelota 
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mRNA surveillance protein pelota
This model describes the Drosophila protein Pelota, the budding yeast protein DOM34 which it can replace, and a set of closely related archaeal proteins. Members contain a proposed RNA binding motif. The meiotic defect in pelota mutants may be a complex result of a protein translation defect, as suggested in yeast by ribosomal protein RPS30A being a multicopy suppressor and by an altered polyribosome profile in DOM34 mutants rescued by RPS30A. This family is homologous to a family of peptide chain release factors. Pelota is proposed to act in protein translation. [Protein synthesis, Translation factors]
Statistics
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PSSM-Id: 129217
View PSSM: TIGR00111
Aligned: 5 rows
Threshold Bit Score: 461.978
Threshold Setting Gi: 11498443
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VGM_A         4 ISLKKDSFNKGgaVITLLPEDKEDLFTVYQIVDKDD-ELIFKKKFTSKL--DEAGKKK-STDLVKLKIKVISEDFDMKDE 79
gi 496711      4 ISLKKDSFNKGgaVITLLPEDKEDLFTVYQIVDKDD-ELIFKKKFTSKL--DEAGKKK-STDLVKLKIKVISEDFDMKDE 79
gi 499179710   8 MRIVEEDEKNG--VIELVPETLDDLWHLSHIIEEGDlLSARTTRRIQDTsgEKIRSDRgVKKTFYLGIRVETVSFHIYTG 85
gi 2495842     1 MKIIEEIPQKN--IIKLMPENLDDLWVLYNIIEEGDkIFAVTERRVQDKg-DVIRADRgAKRKMFLGIEVKNVEFDENTK 77
gi 499180800   1 MQIVEENLRDNegEIKLIPETLDDLWHLRFIIEKGDvVFATTKRASQSS--DKLRSDK-EMVTVRLGIEVEKVEFHRFAN 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VGM_A        80 YLKYKGVTVTdesGAsnVDIPVGKYLSFTLDYVYPFTIIKQnFNKFMQKLLNEACNIEYKSDTAAVVLQEGIAHVCLVTS 159
gi 496711     80 YLKYKGVTVTdesGAsnVDIPVGKYLSFTLDYVYPFTIIKQnFNKFMQKLLNEACNIEYKSDTAAVVLQEGIAHVCLVTS 159
gi 499179710  86 RLRATGVIER---GPe-DLVPMGSHHTLEVKLNTPLRIQKEhWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIRQ 161
gi 2495842    78 RVRILGTIIH---GP--DDVPLGSHHTIEIKPFDELSIEKN-WKKWQIERIKEAIESSKRPKVLVVVMDDEEADIFEVRD 151
gi 499180800  78 RLRVSGKIVA---GIe-ES----GYHTLNITVGKELSIIKK-WKPEQLERLRRAVEDSNRPEIVMLTIEEGYAVAGVLRQ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VGM_A       160 SSTILKQKIEYSMpKKK-RTtdvLKFDEKTEKFYKAIysaMKKDLNFdKLKTIILCSPGFYAKILMDKIFQYAEEEHNKK 238
gi 496711    160 SSTILKQKIEYSMpKKK-RTtdvLKFDEKTEKFYKAIysaMKKDLNFdKLKTIILCSPGFYAKILMDKIFQYAEEEHNKK 238
gi 499179710 162 YGVEYRGPITGHIpGKRiQQ---RDRGKLRREFYESI---VESLQKYgDLETIIIAGPGFYKSDFYDYLMERYPEIAKKA 235
gi 2495842   152 YSIKEICSIKSHT-SKKlDY---KINEELKKEYYHEI---AKVLSEY-DVDNILVAGPGFAKNSFYNFISSQYPELKNKI 223
gi 499180800 149 WGVEEIFEERMGY-GKG--------MGDSRKEFFGEV---AAKLESF-DFKYLIVAGPGFAKNDFLDFLKERYPEMAKNA 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VGM_A       239 ILDNkgmffiahCSTGYLQGINEVLKNPLYASKLQDTKYSKEIMVMDEFLLHLNKDDdKAWYGEKEVVKAAEYGAISYLL 318
gi 496711    239 ILDNkgmffiahCSTGYLQGINEVLKNPLYASKLQDTKYSKEIMVMDEFLLHLNKDDdKAWYGEKEVVKAAEYGAISYLL 318
gi 499179710 236 VLEN--------TGTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPdSVVYGKVEVMDAINMGAVEKLL 307
gi 2495842   224 VVES--------ISTTSRAGLNEVIKRGIINRIYAESRVAKETQLIEKLLEEIAKKG-LAVYGIDEVKKALEYSAIDTLL 294
gi 499180800 216 VVVD--------VSSVGSRGFIEILKRRVVDKIVGEVRLAEEAEYIDRLLEGIAK-GeRVAYGLDEVREAHNYRAIEVLL 286
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
2VGM_A       319 LTDKVlhsdniA---QREEYLKLMDSVESNGGKALVLSTLHSLGEELDQLTGIACILKYPL 376
gi 496711    319 LTDKVlhsdniA---QREEYLKLMDSVESNGGKALVLSTLHSLGEELDQLTGIACILKYPL 376
gi 499179710 308 VLDRV------V---SREDIEGYLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKI 359
gi 2495842   295 VSDSL------V---RNHEIEKIIDTTEEMGGKVVIVSSEHDAGKQLKALGGIAGLLRFPI 346
gi 499180800 287 VADEFl-----LeerEKWDVDGLLREVEESGGKVVIMSTEFEPGKRLMSLGGIAALLRFNV 342
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