1H47


Conserved Protein Domain Family
ispF

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TIGR00151: ispF 
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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Members of this protein family are 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, the IspF protein of the deoxyxylulose (non-mevalonate) pathway of IPP biosynthesis. This protein occurs as an IspDF bifunctional fusion protein in about 20 percent of bacterial genomes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Statistics
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PSSM-Id: 129255
View PSSM: TIGR00151
Aligned: 16 rows
Threshold Bit Score: 207.913
Threshold Setting Gi: 12230315
Created: 7-Oct-2014
Updated: 11-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1H47_A        4 RIGHGFDVHAFGGEGPIIIGGVRIpYEK-GLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREA 82
gi 7531239    4 RIGFGFDSHEFVEGKLLILGGVEI-EKDyGLKGHSDGDALLHAITDAILGALGERDIGEIFKDTDPRWKNAPSRIFLEKA 82
gi 12230315   7 RIGYGEDAHRLAPGLPLVLGGVAIpHAElGAVAHSDGDAVLHAVADALLSGLALGDIGQYFPDTAAEWKGMDSRRILAKA 86
gi 21362638 226 RVGQGFDAHRWGPGEEVWLCGVAIkHDE-TLVGHSDADAGLHALTDAILGAIGEGDIGDHFPPTDPKWKGAASDQFLKHA 304
gi 7531261    6 RVGLGTDVHPIEPGRPCWLVGLLFpSAD-GCAGHSDGDVAVHALCDAVLSAAGLGDIGEVFGVDDPRWQGVSGADMLRHV 84
gi 12230299  16 RIGQGYDVHAFGPGDHVMLGGVRVpHRC-GVLAHSDGDVILHALCDAMLGALGLGDIGQHFPPSDVRWKGADSGVFVRHC 94
gi 20978475   2 RIGMGYDVHKLVENRDLILGGVKIpYEK-GLLGHSDADVLLHAIMDSLLGAAALGDIGKHFPDTDPKYKGADSIKLLEFV 80
gi 22095773   3 RIGNGYDVHKLVEGRKLMLGGVEVpHTK-GVLGHSDGDVLLHAITDAIIGALGLGDIGLHFPDNDENLKDIDSAILLKKI 81
gi 7531245    5 RIGNGYDIHRLVGDRPLILGGVTIaHHL-GLDGHSDADVLTHALMDALLGALSLGDIGHYFPPSDARWQGADSLKLLAQV 83
gi 11387296   2 RIGYGFDLHAFGSTKPLIIGGVLIpCEK-GLIAHSNGDLLIHSLIDALLGATAMGDIGSFFPSNNYIYKNIDSRILLKKI 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1H47_A       83 WRRIQAkGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEklGFTgRGEGIACEAVALLIK 158
gi 7531239   83 LEVMSEkGFNISNIDCVIVADRPKIAPHKERIKESLSKLLGIPKERISLKGKRRE--GFC-EGNGLVCMCTVLLVK 155
gi 12230315  87 LELVEErGYRPVNVALVVTLDRPKLGPLRADIAASVAELLGLPAGEVGVSFKTSE--GLA--LEHVQTRVTVLLGR 158
gi 21362638 305 VDLVTAkGGALVNVDVTLICERPKIKPHRQAMRERLAEILSIPVDRVSVKATTTEkmGFTgRGEGLAASAVVAVET 380
gi 7531261   85 VVLITQhGYRVGNAVVQVIGNRPKIGWRRLEAQAVLSRLLNAP---VSVSATTTDglGLTgRGEGLAAIATALVVS 157
gi 12230299  95 HLLLRErDWCVGNVDATAICESPKIAPYVNAMREGIARLLEVQPECVSVKATTSEglGFIgRGEGLAAQVVVLLYR 170
gi 20978475  81 GELLNKnNYKISNIDATIIAQRPKMAPHIPTMRENIAKALNIDLDQINVKATTEEglGFTgSGEGISSQSICLLVK 156
gi 22095773  82 NNIMKEkNYKIVNLDSIIVMQKPKLRPYIDSIRDNIAKILEINSELINVKAKTEEklGFTgDETGVKSYCVVLLEK 157
gi 7531245   84 HQLILErGWRINNLDNVIVAEQPKLKPHIQAMKENLAKVLTIDPDLIGIKATTNErlGPTgREEGIAAYSVALLIK 159
gi 11387296  81 WNKIILlNYDICNIDITIIAEYPKMLPYIFFMRSNLSLDLNTEIDNISIKSTTSKkiGCIgRKEAIACHSIVMLIK 156
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