1NFH,1NH9


Conserved Protein Domain Family
TIGR00285

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TIGR00285: TIGR00285 
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DNA-binding protein Alba
Alba has been shown to bind DNA and affect DNA supercoiling in a temperature dependent manner. It is regulated by acetylation (alba = acetylation lowers binding affinity) by the Sir2 protein. Alba is proposed to play a role in establishment or maintenace of chromatin architecture and thereby in transcription repression. This protein appears so far only in the Archaea, but may be universal there. There is a single member in three of the first four completed archaeal genomes, and a second copy in A. fulgidus. In Sulfolobus shibatae there is a tandem second copy that is poorly conserved and scores below the trusted cutoff; all other members of the family are conserved at greater than 50 % pairwise identity. [DNA metabolism, Chromosome-associated proteins]
Statistics
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PSSM-Id: 129386
View PSSM: TIGR00285
Aligned: 5 rows
Threshold Bit Score: 102.985
Threshold Setting Gi: 2495857
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1NFH_A        3 EHVVYVGNKPVMNYVLATLTQLNEgADEVVIKARGRAISRAVDVAEIVRNRFMPGVKVKEIKIDTEELESEQGRRSNVST 82
gi 2495857    2 DNVVLIGKKPVMNYVVAVLTQLTS-NDEVIIKARGKAINKAVDVAEMIRNRFIKDIKIKKIEIGTDKVKNPDGREVNVST 80
gi 499179553  5 ENVVYIGNKPVMNYVLAVVTQMNGgTSEVILKARGIAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATNVSA 84
gi 499181027  3 ENSVFVGNKPVMNYVLAVLTQFNSgATEVSIKARGRAISRAVDVAEIVRKRFLPDVDVKDIKISTEQIDSEQGT-ANVSA 81
1NH9_A        2 DNVVLIGKKPVMNYVVAVLTQLTS-NDEVIIKARGKAINKAVDVAEMIRNRFIKDIKIKKIEIGTDKVKNPDGREVNVST 80

                ....*..
1NFH_A       83 IEIVLAK 89
gi 2495857   81 IEIVLAK 87
gi 499179553 85 IEIQLRK 91
gi 499181027 82 IEIILAK 88
1NH9_A       81 IEIVLAK 87
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